Immunogenicity and protective efficacy of a Plasmodium yoelii Hsp60 DNA vaccine in BALB/c mice

The gene encoding the 60-kDa heat shock protein of Plasmodium yoelii (PyHsp60) was cloned into the VR1012 and VR1020 mammalian expression vectors. Groups of 10 BALB/c mice were immunized intramuscularly at 0, 3, and 9 weeks with 100 microg of PyHsp60 DNA vaccine alone or in combination with 30 micro...

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Veröffentlicht in:	Infection and immunity 2001-06, Vol.69 (6), p.3897-3905
Hauptverfasser:	SANCHEZ, Gloria I, SEDEGAH, Martha, ROGERS, William O, JONES, Trevor R, SACCI, John, WITNEY, Adam, CARUCCI, Daniel J, KUMAR, Nirbhay, HOFFMAN, Stephen L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Protozoan - blood Antigens, Protozoan - immunology Bacteriology Biological and medical sciences Chaperonin 60 - genetics Chaperonin 60 - immunology Chaperonin 60 - metabolism Female Fundamental and applied biological sciences. Psychology Fungal and Parasitic Infections Granulocyte-Macrophage Colony-Stimulating Factor - genetics Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Hsp60 protein Immunization Immunization Schedule Malaria - immunology Malaria - prevention & control Malaria Vaccines - immunology Mice Mice, Inbred BALB C Microbiology parasitemia Plasmids - genetics Plasmodium yoelii Plasmodium yoelii - immunology Protozoa Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, DNA - immunology
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