Systematic Review and Meta-analysis on Extended-Spectrum β-lactamases Producing Klebsiella pneumoniae in Nepal
Objective: This systematic review and meta-analysis aimed to assess the pool estimates of extended-spectrum β-lactamases producing K. pneumoniae (ESBL-KP) and study their drug resistance profile by evaluating the studies from Nepal. Methods: A literature search was carried out in PubMed, Google Scho...
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| Veröffentlicht in: | Microbiology Insights 2023-01, Vol.16, p.11786361221145179-11786361221145179 |
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| creator | Shyaula, Manita Khadka, Christina Dawadi, Prabin Banjara, Megha Raj |
| description | Objective:
This systematic review and meta-analysis aimed to assess the pool estimates of extended-spectrum β-lactamases producing K. pneumoniae (ESBL-KP) and study their drug resistance profile by evaluating the studies from Nepal.
Methods:
A literature search was carried out in PubMed, Google Scholar, and NepJOL to screen all articles on ESBL-KP published between 2011 and 2021 from Nepal. This review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Relevant data were extracted, and R language 4.2.0 software was used for statistical analysis.
Results:
The pooled prevalence of K. pneumoniae was 5%, while the pooled prevalence of ESBL and multidrug resistance (MDR) in K. pneumoniae were 23% and 55%, respectively. Imipenem was the drug of choice (in vitro) against ESBL-KP infection.
Conclusion:
Our analyses showed a high prevalence of ESBL-KP and their high resistance toward commonly used drugs. This study highlights the need for the development of new antibiotics for the management of ESBL-KP infections. |
| doi_str_mv | 10.1177/11786361221145179 |
| format | Article |
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This systematic review and meta-analysis aimed to assess the pool estimates of extended-spectrum β-lactamases producing K. pneumoniae (ESBL-KP) and study their drug resistance profile by evaluating the studies from Nepal.
Methods:
A literature search was carried out in PubMed, Google Scholar, and NepJOL to screen all articles on ESBL-KP published between 2011 and 2021 from Nepal. This review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Relevant data were extracted, and R language 4.2.0 software was used for statistical analysis.
Results:
The pooled prevalence of K. pneumoniae was 5%, while the pooled prevalence of ESBL and multidrug resistance (MDR) in K. pneumoniae were 23% and 55%, respectively. Imipenem was the drug of choice (in vitro) against ESBL-KP infection.
Conclusion:
Our analyses showed a high prevalence of ESBL-KP and their high resistance toward commonly used drugs. This study highlights the need for the development of new antibiotics for the management of ESBL-KP infections.</description><identifier>ISSN: 1178-6361</identifier><identifier>EISSN: 1178-6361</identifier><identifier>DOI: 10.1177/11786361221145179</identifier><identifier>PMID: 36655025</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Antibiotics ; Drug development ; Drug resistance ; High resistance ; Imipenem ; Klebsiella ; Meta-analysis ; Multidrug resistance ; Review ; Reviews ; Search engines ; Statistical analysis ; Systematic review ; β Lactamase</subject><ispartof>Microbiology Insights, 2023-01, Vol.16, p.11786361221145179-11786361221145179</ispartof><rights>The Author(s) 2023</rights><rights>The Author(s) 2023.</rights><rights>The Author(s) 2023. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2023 2023 SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3119-534dbea9c44481d1e65fec120555fb8f095b69e123a4e9e39dc9410d04edeb863</citedby><cites>FETCH-LOGICAL-c3119-534dbea9c44481d1e65fec120555fb8f095b69e123a4e9e39dc9410d04edeb863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841864/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841864/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,313,314,723,776,780,788,881,27901,27903,27904,53770,53772</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36655025$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shyaula, Manita</creatorcontrib><creatorcontrib>Khadka, Christina</creatorcontrib><creatorcontrib>Dawadi, Prabin</creatorcontrib><creatorcontrib>Banjara, Megha Raj</creatorcontrib><title>Systematic Review and Meta-analysis on Extended-Spectrum β-lactamases Producing Klebsiella pneumoniae in Nepal</title><title>Microbiology Insights</title><addtitle>Microbiol Insights</addtitle><description>Objective:
This systematic review and meta-analysis aimed to assess the pool estimates of extended-spectrum β-lactamases producing K. pneumoniae (ESBL-KP) and study their drug resistance profile by evaluating the studies from Nepal.
Methods:
A literature search was carried out in PubMed, Google Scholar, and NepJOL to screen all articles on ESBL-KP published between 2011 and 2021 from Nepal. This review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Relevant data were extracted, and R language 4.2.0 software was used for statistical analysis.
Results:
The pooled prevalence of K. pneumoniae was 5%, while the pooled prevalence of ESBL and multidrug resistance (MDR) in K. pneumoniae were 23% and 55%, respectively. Imipenem was the drug of choice (in vitro) against ESBL-KP infection.
Conclusion:
Our analyses showed a high prevalence of ESBL-KP and their high resistance toward commonly used drugs. This study highlights the need for the development of new antibiotics for the management of ESBL-KP infections.</description><subject>Antibiotics</subject><subject>Drug development</subject><subject>Drug resistance</subject><subject>High resistance</subject><subject>Imipenem</subject><subject>Klebsiella</subject><subject>Meta-analysis</subject><subject>Multidrug resistance</subject><subject>Review</subject><subject>Reviews</subject><subject>Search engines</subject><subject>Statistical analysis</subject><subject>Systematic review</subject><subject>β Lactamase</subject><issn>1178-6361</issn><issn>1178-6361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kctu1TAQhi1ERau2D8AGWWLDJq0nviTeIKGqBdRyEYV15NiTg6vEDnFSOK_VB-kz4aNTSgHhhT0af_PbMz8hT4EdAVTVcd5qxRWUJYCQUOlHZG-TKzbJxw_iXXKY0hXLi3OoOX9CdrlSUrJS7pF4uU4zDmb2ln7Ca4_fqQmOvsPZFCaYfp18ojHQ0x8zBoeuuBzRztMy0Nubojd2NoNJmOjHKbrF-rCi5z22yWPfGzoGXIYYvEHqA32Po-kPyE5n-oSHd-c--XJ2-vnkTXHx4fXbk1cXheUAupBcuBaNtkKIGhygkh1aKJmUsmvrjmnZKo1QciNQI9fOagHMMYEO2zyXffJyqzsu7YDOYpgn0zfj5AczrZtofPPnTfBfm1W8bnQtoFYiC7y4E5jitwXT3Aw-2U1bAeOSmrJSFVSsUjyjz_9Cr-Iy5eFlSpcMsgm6zhRsKTvFlCbs7j8DrNk42vzjaK559rCL-4pf_mXgaAsks8Lfz_5f8SeJAqqJ</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Shyaula, Manita</creator><creator>Khadka, Christina</creator><creator>Dawadi, Prabin</creator><creator>Banjara, Megha Raj</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AYAGU</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7N</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202301</creationdate><title>Systematic Review and Meta-analysis on Extended-Spectrum β-lactamases Producing Klebsiella pneumoniae in Nepal</title><author>Shyaula, Manita ; Khadka, Christina ; Dawadi, Prabin ; Banjara, Megha Raj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3119-534dbea9c44481d1e65fec120555fb8f095b69e123a4e9e39dc9410d04edeb863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antibiotics</topic><topic>Drug development</topic><topic>Drug resistance</topic><topic>High resistance</topic><topic>Imipenem</topic><topic>Klebsiella</topic><topic>Meta-analysis</topic><topic>Multidrug resistance</topic><topic>Review</topic><topic>Reviews</topic><topic>Search engines</topic><topic>Statistical analysis</topic><topic>Systematic review</topic><topic>β Lactamase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shyaula, Manita</creatorcontrib><creatorcontrib>Khadka, Christina</creatorcontrib><creatorcontrib>Dawadi, Prabin</creatorcontrib><creatorcontrib>Banjara, Megha Raj</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>Australia & New Zealand Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Microbiology Insights</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shyaula, Manita</au><au>Khadka, Christina</au><au>Dawadi, Prabin</au><au>Banjara, Megha Raj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Systematic Review and Meta-analysis on Extended-Spectrum β-lactamases Producing Klebsiella pneumoniae in Nepal</atitle><jtitle>Microbiology Insights</jtitle><addtitle>Microbiol Insights</addtitle><date>2023-01</date><risdate>2023</risdate><volume>16</volume><spage>11786361221145179</spage><epage>11786361221145179</epage><pages>11786361221145179-11786361221145179</pages><issn>1178-6361</issn><eissn>1178-6361</eissn><abstract>Objective:
This systematic review and meta-analysis aimed to assess the pool estimates of extended-spectrum β-lactamases producing K. pneumoniae (ESBL-KP) and study their drug resistance profile by evaluating the studies from Nepal.
Methods:
A literature search was carried out in PubMed, Google Scholar, and NepJOL to screen all articles on ESBL-KP published between 2011 and 2021 from Nepal. This review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Relevant data were extracted, and R language 4.2.0 software was used for statistical analysis.
Results:
The pooled prevalence of K. pneumoniae was 5%, while the pooled prevalence of ESBL and multidrug resistance (MDR) in K. pneumoniae were 23% and 55%, respectively. Imipenem was the drug of choice (in vitro) against ESBL-KP infection.
Conclusion:
Our analyses showed a high prevalence of ESBL-KP and their high resistance toward commonly used drugs. This study highlights the need for the development of new antibiotics for the management of ESBL-KP infections.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>36655025</pmid><doi>10.1177/11786361221145179</doi><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1178-6361 |
| ispartof | Microbiology Insights, 2023-01, Vol.16, p.11786361221145179-11786361221145179 |
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| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access; PubMed Central |
| subjects | Antibiotics Drug development Drug resistance High resistance Imipenem Klebsiella Meta-analysis Multidrug resistance Review Reviews Search engines Statistical analysis Systematic review β Lactamase |
| title | Systematic Review and Meta-analysis on Extended-Spectrum β-lactamases Producing Klebsiella pneumoniae in Nepal |
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