Interfering with nucleotide excision by the coronavirus 3'-to-5' exoribonuclease

Some of the most efficacious antiviral therapeutics are ribonucleos(t)ide analogs. The presence of a 3'-to-5' proofreading exoribonuclease (ExoN) in coronaviruses diminishes the potency of many ribonucleotide analogs. The ability to interfere with ExoN activity will create new possibilitie...

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Veröffentlicht in:	Nucleic acids research 2023-01, Vol.51 (1), p.315-336
Hauptverfasser:	Chinthapatla, Rukesh, Sotoudegan, Mohamad, Srivastava, Pankaj, Anderson, Thomas K, Moustafa, Ibrahim M, Passow, Kellan T, Kennelly, Samantha A, Moorthy, Ramkumar, Dulin, David, Feng, Joy Y, Harki, Daniel A, Kirchdoerfer, Robert N, Cameron, Craig E, Arnold, Jamie J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents - pharmacology COVID-19 Drug Treatment Drug Design Exoribonucleases - metabolism Humans Nucleic Acid Enzymes Ribonucleotides - chemistry RNA, Viral - genetics RNA, Viral - metabolism SARS-CoV-2 - genetics SARS-CoV-2 - metabolism Viral Nonstructural Proteins - metabolism Virus Replication - genetics
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