Structural domains of SARS-CoV-2 nucleocapsid protein coordinate to compact long nucleic acid substrates

The SARS-CoV-2 nucleocapsid (N) protein performs several functions including binding, compacting, and packaging the ∼30 kb viral genome into the viral particle. N protein consists of two ordered domains, with the N terminal domain (NTD) primarily associated with RNA binding and the C terminal domain...

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Veröffentlicht in:	Nucleic acids research 2023-01, Vol.51 (1), p.290-303
Hauptverfasser:	Morse, Michael, Sefcikova, Jana, Rouzina, Ioulia, Beuning, Penny J, Williams, Mark C
Format:	Artikel
Sprache:	eng
Schlagworte:	Coronavirus Nucleocapsid Proteins - metabolism COVID-19 - virology Humans Molecular Biology Protein Domains RNA, Viral - metabolism SARS-CoV-2 - genetics SARS-CoV-2 - metabolism
Online-Zugang:	Volltext
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