18F-Fluciclovine PET Imaging of Glutaminase Inhibition in Breast Cancer Models

Aggressive cancers such as triple-negative breast cancer (TNBC) avidly metabolize glutamine as a feature of their malignant phenotype. The conversion of glutamine to glutamate by the glutaminase enzyme represents the first and rate-limiting step of this pathway and a target for drug development. Ind...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2023-01, Vol.64 (1), p.131-136
Hauptverfasser:	Zhou, Rong, Choi, Hoon, Cao, Jianbo, Pantel, Austin, Gupta, Mamta, Lee, Hsiaoju S, Mankoff, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Basic Science Investigation Biomarkers Breast cancer Clinical trials Drug development Estrogen receptors Estrogens Fluorine isotopes Glutaminase Glutamine Medical imaging Pharmacodynamics Pharmacology Phenotypes Positron emission Positron emission tomography Tumors Xenografts Xenotransplantation
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