Preimplantation genetic testing for aneuploidy: helpful but not a first choice
Purpose This retrospective cohort study aimed to assess and compare the outcomes between cumulative live birth of patients with and without PGT-A and also between prior unsuccessful IVF cycles and PGT-A cycles among patients who experienced IVF but without live birth delivery, and to clarify the eff...
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| Veröffentlicht in: | Journal of assisted reproduction and genetics 2023-01, Vol.40 (1), p.161-168 |
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| container_title | Journal of assisted reproduction and genetics |
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| creator | Ohishi, Sachiko Otani, Tetsuo |
| description | Purpose
This retrospective cohort study aimed to assess and compare the outcomes between cumulative live birth of patients with and without PGT-A and also between prior unsuccessful IVF cycles and PGT-A cycles among patients who experienced IVF but without live birth delivery, and to clarify the effective usage of PGT-A as an in vitro fertilization (IVF) add-on.
Methods
A total of 2113 females undergoing IVF with at least one blastocyst were reviewed. Patients in the PGT-A and non-PGT-A groups were further categorized into first-time IVF and prior unsuccessful IVF groups (previous IVF experience but without live birth delivery).
Results
In the PGT-A group, there were additional oocyte retrieval cycles, fewer transfer cycles per patient, higher clinical pregnancy rates per embryo transfer, and lower miscarriage rates per clinical pregnancy as compared to the non-PGT-A group, all showing significant differences. However, the first-time IVF group with PGT-A had a significantly longer duration from the first oocyte retrieval to the first live birth delivery (LBD) and a significantly lower LBD rate per patient than the non-PGT-A group. The cumulative probability for a first LBD with PGT-A was inferior in the first-time IVF group for women |
| doi_str_mv | 10.1007/s10815-022-02683-x |
| format | Article |
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This retrospective cohort study aimed to assess and compare the outcomes between cumulative live birth of patients with and without PGT-A and also between prior unsuccessful IVF cycles and PGT-A cycles among patients who experienced IVF but without live birth delivery, and to clarify the effective usage of PGT-A as an in vitro fertilization (IVF) add-on.
Methods
A total of 2113 females undergoing IVF with at least one blastocyst were reviewed. Patients in the PGT-A and non-PGT-A groups were further categorized into first-time IVF and prior unsuccessful IVF groups (previous IVF experience but without live birth delivery).
Results
In the PGT-A group, there were additional oocyte retrieval cycles, fewer transfer cycles per patient, higher clinical pregnancy rates per embryo transfer, and lower miscarriage rates per clinical pregnancy as compared to the non-PGT-A group, all showing significant differences. However, the first-time IVF group with PGT-A had a significantly longer duration from the first oocyte retrieval to the first live birth delivery (LBD) and a significantly lower LBD rate per patient than the non-PGT-A group. The cumulative probability for a first LBD with PGT-A was inferior in the first-time IVF group for women < 35 years, marginally superior in the prior unsuccessful IVF group of women aged 38–40 years, and similar for other groups.
Conclusion
PGT-A should not be recommended to all patients; however, if the first IVF treatment failed, PGT-A may reduce the patient’s burden regardless of age.</description><identifier>ISSN: 1058-0468</identifier><identifier>EISSN: 1573-7330</identifier><identifier>DOI: 10.1007/s10815-022-02683-x</identifier><identifier>PMID: 36508033</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Aneuploidy ; Assisted Reproduction Technologies ; Birth ; Embryo transfer ; Female ; Fertilization in Vitro ; Genetic screening ; Genetic Testing ; Gynecology ; Human Genetics ; Humans ; In vitro fertilization ; Medicine ; Medicine & Public Health ; Patients ; Pregnancy ; Pregnancy Rate ; Preimplantation Diagnosis ; Reproductive Medicine ; Retrospective Studies</subject><ispartof>Journal of assisted reproduction and genetics, 2023-01, Vol.40 (1), p.161-168</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c397t-6197c25e7866395e84bbbe5f87245b2972859e3e9fae4c943ad26c9853d766733</citedby><cites>FETCH-LOGICAL-c397t-6197c25e7866395e84bbbe5f87245b2972859e3e9fae4c943ad26c9853d766733</cites><orcidid>0000-0003-1724-8072 ; 0000-0002-2256-905X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840739/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840739/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36508033$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ohishi, Sachiko</creatorcontrib><creatorcontrib>Otani, Tetsuo</creatorcontrib><title>Preimplantation genetic testing for aneuploidy: helpful but not a first choice</title><title>Journal of assisted reproduction and genetics</title><addtitle>J Assist Reprod Genet</addtitle><addtitle>J Assist Reprod Genet</addtitle><description>Purpose
This retrospective cohort study aimed to assess and compare the outcomes between cumulative live birth of patients with and without PGT-A and also between prior unsuccessful IVF cycles and PGT-A cycles among patients who experienced IVF but without live birth delivery, and to clarify the effective usage of PGT-A as an in vitro fertilization (IVF) add-on.
Methods
A total of 2113 females undergoing IVF with at least one blastocyst were reviewed. Patients in the PGT-A and non-PGT-A groups were further categorized into first-time IVF and prior unsuccessful IVF groups (previous IVF experience but without live birth delivery).
Results
In the PGT-A group, there were additional oocyte retrieval cycles, fewer transfer cycles per patient, higher clinical pregnancy rates per embryo transfer, and lower miscarriage rates per clinical pregnancy as compared to the non-PGT-A group, all showing significant differences. However, the first-time IVF group with PGT-A had a significantly longer duration from the first oocyte retrieval to the first live birth delivery (LBD) and a significantly lower LBD rate per patient than the non-PGT-A group. The cumulative probability for a first LBD with PGT-A was inferior in the first-time IVF group for women < 35 years, marginally superior in the prior unsuccessful IVF group of women aged 38–40 years, and similar for other groups.
Conclusion
PGT-A should not be recommended to all patients; however, if the first IVF treatment failed, PGT-A may reduce the patient’s burden regardless of age.</description><subject>Aneuploidy</subject><subject>Assisted Reproduction Technologies</subject><subject>Birth</subject><subject>Embryo transfer</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Genetic screening</subject><subject>Genetic Testing</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>In vitro fertilization</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Patients</subject><subject>Pregnancy</subject><subject>Pregnancy Rate</subject><subject>Preimplantation Diagnosis</subject><subject>Reproductive Medicine</subject><subject>Retrospective Studies</subject><issn>1058-0468</issn><issn>1573-7330</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp9UU1PHDEMjRCoUOAPcECROA_NJJOvHpAQamklBD205yiT9ewGzSbTJIPYf0_oUmgvHCxb8vN7th9CJy05bwmRn3JLVMsbQmkNoVjzuIMOWi5ZIxkju7UmXDWkE2offcz5nhCiFWUf0D4TnCjC2AG6_ZHAr6fRhmKLjwEvIUDxDhfIxYclHmLCNsA8jdEvNp_xCsZpmEfczwWHWLDFg0-5YLeK3sER2hvsmOH4JR-iX1-__Lz61tzcXX-_urxpHNOyNKLV0lEOUgnBNAfV9X0PfFCSdrynWlLFNTDQg4XO6Y7ZBRVOK84WUoh63SG62PJOc7-GhYNQkh3NlPzapo2J1pv_O8GvzDI-GK06IpmuBGcvBCn-nuut5j7OKdSdDZWCd0R0UlYU3aJcijknGF4VWmKePTBbD0z1wPzxwDzWodN_d3sd-fv0CmBbQK6tsIT0pv0O7ROn3JNr</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Ohishi, Sachiko</creator><creator>Otani, Tetsuo</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1724-8072</orcidid><orcidid>https://orcid.org/0000-0002-2256-905X</orcidid></search><sort><creationdate>20230101</creationdate><title>Preimplantation genetic testing for aneuploidy: helpful but not a first choice</title><author>Ohishi, Sachiko ; Otani, Tetsuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c397t-6197c25e7866395e84bbbe5f87245b2972859e3e9fae4c943ad26c9853d766733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aneuploidy</topic><topic>Assisted Reproduction Technologies</topic><topic>Birth</topic><topic>Embryo transfer</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Genetic screening</topic><topic>Genetic Testing</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>In vitro fertilization</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Patients</topic><topic>Pregnancy</topic><topic>Pregnancy Rate</topic><topic>Preimplantation Diagnosis</topic><topic>Reproductive Medicine</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ohishi, Sachiko</creatorcontrib><creatorcontrib>Otani, Tetsuo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of assisted reproduction and genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ohishi, Sachiko</au><au>Otani, Tetsuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preimplantation genetic testing for aneuploidy: helpful but not a first choice</atitle><jtitle>Journal of assisted reproduction and genetics</jtitle><stitle>J Assist Reprod Genet</stitle><addtitle>J Assist Reprod Genet</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>40</volume><issue>1</issue><spage>161</spage><epage>168</epage><pages>161-168</pages><issn>1058-0468</issn><eissn>1573-7330</eissn><abstract>Purpose
This retrospective cohort study aimed to assess and compare the outcomes between cumulative live birth of patients with and without PGT-A and also between prior unsuccessful IVF cycles and PGT-A cycles among patients who experienced IVF but without live birth delivery, and to clarify the effective usage of PGT-A as an in vitro fertilization (IVF) add-on.
Methods
A total of 2113 females undergoing IVF with at least one blastocyst were reviewed. Patients in the PGT-A and non-PGT-A groups were further categorized into first-time IVF and prior unsuccessful IVF groups (previous IVF experience but without live birth delivery).
Results
In the PGT-A group, there were additional oocyte retrieval cycles, fewer transfer cycles per patient, higher clinical pregnancy rates per embryo transfer, and lower miscarriage rates per clinical pregnancy as compared to the non-PGT-A group, all showing significant differences. However, the first-time IVF group with PGT-A had a significantly longer duration from the first oocyte retrieval to the first live birth delivery (LBD) and a significantly lower LBD rate per patient than the non-PGT-A group. The cumulative probability for a first LBD with PGT-A was inferior in the first-time IVF group for women < 35 years, marginally superior in the prior unsuccessful IVF group of women aged 38–40 years, and similar for other groups.
Conclusion
PGT-A should not be recommended to all patients; however, if the first IVF treatment failed, PGT-A may reduce the patient’s burden regardless of age.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36508033</pmid><doi>10.1007/s10815-022-02683-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-1724-8072</orcidid><orcidid>https://orcid.org/0000-0002-2256-905X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of assisted reproduction and genetics, 2023-01, Vol.40 (1), p.161-168 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Aneuploidy Assisted Reproduction Technologies Birth Embryo transfer Female Fertilization in Vitro Genetic screening Genetic Testing Gynecology Human Genetics Humans In vitro fertilization Medicine Medicine & Public Health Patients Pregnancy Pregnancy Rate Preimplantation Diagnosis Reproductive Medicine Retrospective Studies |
| title | Preimplantation genetic testing for aneuploidy: helpful but not a first choice |
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