Mesenchymal stromal cells improve the transplantation outcome of CRISPR-Cas9 gene-edited human HSPCs

Mesenchymal stromal cells (MSCs) have been employed in vitro to support hematopoietic stem and progenitor cell (HSPC) expansion and in vivo to promote HSPC engraftment. Based on these studies, we developed an MSC-based co-culture system to optimize the transplantation outcome of clustered regularly...

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Veröffentlicht in:Molecular therapy 2023-01, Vol.31 (1), p.230-248
Hauptverfasser: Crippa, Stefania, Conti, Anastasia, Vavassori, Valentina, Ferrari, Samuele, Beretta, Stefano, Rivis, Silvia, Bosotti, Roberto, Scala, Serena, Pirroni, Stefania, Jofra-Hernandez, Raisa, Santi, Ludovica, Basso-Ricci, Luca, Merelli, Ivan, Genovese, Pietro, Aiuti, Alessandro, Naldini, Luigi, Di Micco, Raffaella, Bernardo, Maria Ester
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