Establishment and Application of a Novel In Vitro Model of Microglial Activation in Traumatic Brain Injury

Mechanical impact-induced primary injury after traumatic brain injury (TBI) leads to acute microglial pro-inflammatory activation and consequently mediates neurodegeneration, which is a major secondary brain injury mechanism. However, the detailed pathologic cascades have not been fully elucidated,...

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Veröffentlicht in:	The Journal of neuroscience 2023-01, Vol.43 (2), p.319-332
Hauptverfasser:	Liu, Ning, Li, Yadan, Jiang, Yinghua, Shi, Samuel, Niamnud, Aim, Vodovoz, Sammy J, Katakam, Prasad V G, Vidoudez, Charles, Dumont, Aaron S, Wang, Xiaoying
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Brain Brain Injuries, Traumatic - pathology Damage patterns Degeneration Head injuries Inflammation Macrophages - metabolism Male Metabolism Mice Mice, Inbred C57BL Microglia Microglia - metabolism Neurodegeneration Neurons - metabolism Traumatic brain injury
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