Aquaporin5 Deficiency Aggravates ROS/NLRP3 Inflammasome-Mediated Pyroptosis in the Lacrimal Glands

The pathogenesis of the lacrimal glands (LGs) is facilitated by inflammation mediated by the NACHT, LRR, and NLRP3 inflammasomes in dry eye disease. This research aimed to explore the protective effects of Aquaporin 5 (AQP5) on LGs by inhibiting reactive oxygen species (ROS) and the NLRP3 inflammaso...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2023-01, Vol.64 (1), p.4-4
Hauptverfasser:	Cao, Xin, Di, Guohu, Bai, Ying, Zhang, Kaier, Wang, Yihui, Zhao, Hui, Wang, Dianqiang, Chen, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Animals Biochemistry and Molecular Biology Caspase 1 - metabolism Cell Line Dry Eye Syndromes - metabolism Inflammasomes - metabolism Lacrimal Apparatus - metabolism Mice NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Pyroptosis Reactive Oxygen Species - metabolism
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