Predicting serum hormone concentration by estimation of urinary hormones through a home-use device
Abstract STUDY QUESTION Can a home-use device be used to predict serum hormone levels? SUMMARY ANSWER A home-use device can predict urinary hormone values which are well-correlated to serum concentrations of respective hormones and hence can be used as a proxy for serum measurements. WHAT IS KNOWN A...
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| Veröffentlicht in: | Human reproduction open 2023, Vol.2023 (1), p.hoac058-hoac058 |
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| creator | Pattnaik, Siddharth Das, Dipankar Venkatesan, Varun Akur Rai, Aayush |
| description | Abstract
STUDY QUESTION
Can a home-use device be used to predict serum hormone levels?
SUMMARY ANSWER
A home-use device can predict urinary hormone values which are well-correlated to serum concentrations of respective hormones and hence can be used as a proxy for serum measurements.
WHAT IS KNOWN ALREADY
Home-use devices that predict ovulation are calibrated against the actual day of ovulation. However, the correlation of any quantitative system to serum hormone concentrations has not been established.
STUDY DESIGN, SIZE, DURATION
A total of 73 data points obtained from 20 participants across different phases of the menstrual cycle, i.e. bleeding days, follicular phase and luteal phase were used to establish the correlation between serum hormones and urinary metabolite values. Single data points from 20 random users were used to assess the correlation established.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Participants were women in the fertile age groups and only current users of the home-use device. Selection was done based on inclusion and exclusion criteria. Blood hormones were tested using chemiluminescent immunoassays and urinary measurements were taken on the home-use device at home.
MAIN RESULTS AND THE ROLE OF CHANCE
Serum estradiol (E2), progesterone (P4) and LH were correlated with urinary estrone-3-glucuronide (E3G), pregnanediol glucuronide (PdG) and LH with an R2 of 0.96, 0.95 and 0.98, respectively. Repredicted serum concentration obtained by using the correlation equation had a correlation of 0.92, 0.94 and 0.93 in unknown samples.
LIMITATIONS, REASONS FOR CAUTION
The study was designed to include women who have normal cycle lengths regularly; therefore, the values obtained were in the normal range. Certain infertility conditions may cause the values to be higher and correlation in such cases needs to be established.
WIDER IMPLICATIONS OF THE FINDINGS
The results of this study imply a new tool that can be used by fertility specialists as a proxy for blood tests whenever required. Extended study on this system can enable its use in assisted reproductive techniques as well.
STUDY FUNDING/COMPETING INTEREST(S)
No funding was received for this study. S.P. and D.D. are employees of the research and development division of Samplytics Technologies Pvt. Ltd. which is a forwarder for Inito Inc., USA. A.R. and V.A.V. are co-founders of Inito Inc., USA.
TRIAL REGISTRATION NUMBER
The trial was registered at the International Standard Randomised Controll |
| doi_str_mv | 10.1093/hropen/hoac058 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9838318</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A767366849</galeid><oup_id>10.1093/hropen/hoac058</oup_id><sourcerecordid>A767366849</sourcerecordid><originalsourceid>FETCH-LOGICAL-c491t-e1b6855959c04f8e320e33b728338c1311ed7cf734bca763718abe9b7ffb6dc13</originalsourceid><addsrcrecordid>eNqFkc1rHSEUxaWkJCHNNssiZJMuJtFxZtRNIIR-QaBdtGtR5_rGMKMvOhN4_30M8xJSCBQX6vV3D-d6EDqj5JISya6GFLcQroaoLWnFB3RcMykr1tby4M35CJ3mfE8IoaLmpGaH6Ih1Xdt0Qhwj8ztB7-3swwZnSMuEh5imGADbGCyEOenZx4DNDkOe_bTeosNL8kGn3Que8VzcLJsB61KaoFoy4B4evYVP6KPTY4bT_X6C_n77-uf2R3X36_vP25u7yjaSzhVQ04m2la20pHECWE2AMcNrwZiwlFEKPbeOs8ZYzTvGqdAGpOHOma4vwAm6XnW3i5mgX82PapuK67RTUXv170vwg9rERyUFE4yKInCxF0jxYSnjqslnC-OoA8Qlq5p3nHLCSVfQ8xXd6BGUDy4WRfuMq5tClf8VjSzU5TtUWT1MvvwvOF_q7zXYFHNO4F7dU6KeI1dr5GofeWn4_HbmV_wl4AJ8WYG4bP8n9gTm17nF</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2767170706</pqid></control><display><type>article</type><title>Predicting serum hormone concentration by estimation of urinary hormones through a home-use device</title><source>Oxford Journals Open Access Collection</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Pattnaik, Siddharth ; Das, Dipankar ; Venkatesan, Varun Akur ; Rai, Aayush</creator><creatorcontrib>Pattnaik, Siddharth ; Das, Dipankar ; Venkatesan, Varun Akur ; Rai, Aayush</creatorcontrib><description>Abstract
STUDY QUESTION
Can a home-use device be used to predict serum hormone levels?
SUMMARY ANSWER
A home-use device can predict urinary hormone values which are well-correlated to serum concentrations of respective hormones and hence can be used as a proxy for serum measurements.
WHAT IS KNOWN ALREADY
Home-use devices that predict ovulation are calibrated against the actual day of ovulation. However, the correlation of any quantitative system to serum hormone concentrations has not been established.
STUDY DESIGN, SIZE, DURATION
A total of 73 data points obtained from 20 participants across different phases of the menstrual cycle, i.e. bleeding days, follicular phase and luteal phase were used to establish the correlation between serum hormones and urinary metabolite values. Single data points from 20 random users were used to assess the correlation established.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Participants were women in the fertile age groups and only current users of the home-use device. Selection was done based on inclusion and exclusion criteria. Blood hormones were tested using chemiluminescent immunoassays and urinary measurements were taken on the home-use device at home.
MAIN RESULTS AND THE ROLE OF CHANCE
Serum estradiol (E2), progesterone (P4) and LH were correlated with urinary estrone-3-glucuronide (E3G), pregnanediol glucuronide (PdG) and LH with an R2 of 0.96, 0.95 and 0.98, respectively. Repredicted serum concentration obtained by using the correlation equation had a correlation of 0.92, 0.94 and 0.93 in unknown samples.
LIMITATIONS, REASONS FOR CAUTION
The study was designed to include women who have normal cycle lengths regularly; therefore, the values obtained were in the normal range. Certain infertility conditions may cause the values to be higher and correlation in such cases needs to be established.
WIDER IMPLICATIONS OF THE FINDINGS
The results of this study imply a new tool that can be used by fertility specialists as a proxy for blood tests whenever required. Extended study on this system can enable its use in assisted reproductive techniques as well.
STUDY FUNDING/COMPETING INTEREST(S)
No funding was received for this study. S.P. and D.D. are employees of the research and development division of Samplytics Technologies Pvt. Ltd. which is a forwarder for Inito Inc., USA. A.R. and V.A.V. are co-founders of Inito Inc., USA.
TRIAL REGISTRATION NUMBER
The trial was registered at the International Standard Randomised Controlled Trial Number (ISRCTN) registry (Identifier: ISRCTN15534557).</description><identifier>ISSN: 2399-3529</identifier><identifier>EISSN: 2399-3529</identifier><identifier>DOI: 10.1093/hropen/hoac058</identifier><identifier>PMID: 36654688</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Care and treatment ; Evaluation ; Fertility ; Original ; Patient monitoring equipment</subject><ispartof>Human reproduction open, 2023, Vol.2023 (1), p.hoac058-hoac058</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.</rights><rights>COPYRIGHT 2023 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c491t-e1b6855959c04f8e320e33b728338c1311ed7cf734bca763718abe9b7ffb6dc13</citedby><cites>FETCH-LOGICAL-c491t-e1b6855959c04f8e320e33b728338c1311ed7cf734bca763718abe9b7ffb6dc13</cites><orcidid>0000-0003-4136-5180</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838318/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838318/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1598,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36654688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pattnaik, Siddharth</creatorcontrib><creatorcontrib>Das, Dipankar</creatorcontrib><creatorcontrib>Venkatesan, Varun Akur</creatorcontrib><creatorcontrib>Rai, Aayush</creatorcontrib><title>Predicting serum hormone concentration by estimation of urinary hormones through a home-use device</title><title>Human reproduction open</title><addtitle>Hum Reprod Open</addtitle><description>Abstract
STUDY QUESTION
Can a home-use device be used to predict serum hormone levels?
SUMMARY ANSWER
A home-use device can predict urinary hormone values which are well-correlated to serum concentrations of respective hormones and hence can be used as a proxy for serum measurements.
WHAT IS KNOWN ALREADY
Home-use devices that predict ovulation are calibrated against the actual day of ovulation. However, the correlation of any quantitative system to serum hormone concentrations has not been established.
STUDY DESIGN, SIZE, DURATION
A total of 73 data points obtained from 20 participants across different phases of the menstrual cycle, i.e. bleeding days, follicular phase and luteal phase were used to establish the correlation between serum hormones and urinary metabolite values. Single data points from 20 random users were used to assess the correlation established.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Participants were women in the fertile age groups and only current users of the home-use device. Selection was done based on inclusion and exclusion criteria. Blood hormones were tested using chemiluminescent immunoassays and urinary measurements were taken on the home-use device at home.
MAIN RESULTS AND THE ROLE OF CHANCE
Serum estradiol (E2), progesterone (P4) and LH were correlated with urinary estrone-3-glucuronide (E3G), pregnanediol glucuronide (PdG) and LH with an R2 of 0.96, 0.95 and 0.98, respectively. Repredicted serum concentration obtained by using the correlation equation had a correlation of 0.92, 0.94 and 0.93 in unknown samples.
LIMITATIONS, REASONS FOR CAUTION
The study was designed to include women who have normal cycle lengths regularly; therefore, the values obtained were in the normal range. Certain infertility conditions may cause the values to be higher and correlation in such cases needs to be established.
WIDER IMPLICATIONS OF THE FINDINGS
The results of this study imply a new tool that can be used by fertility specialists as a proxy for blood tests whenever required. Extended study on this system can enable its use in assisted reproductive techniques as well.
STUDY FUNDING/COMPETING INTEREST(S)
No funding was received for this study. S.P. and D.D. are employees of the research and development division of Samplytics Technologies Pvt. Ltd. which is a forwarder for Inito Inc., USA. A.R. and V.A.V. are co-founders of Inito Inc., USA.
TRIAL REGISTRATION NUMBER
The trial was registered at the International Standard Randomised Controlled Trial Number (ISRCTN) registry (Identifier: ISRCTN15534557).</description><subject>Care and treatment</subject><subject>Evaluation</subject><subject>Fertility</subject><subject>Original</subject><subject>Patient monitoring equipment</subject><issn>2399-3529</issn><issn>2399-3529</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNqFkc1rHSEUxaWkJCHNNssiZJMuJtFxZtRNIIR-QaBdtGtR5_rGMKMvOhN4_30M8xJSCBQX6vV3D-d6EDqj5JISya6GFLcQroaoLWnFB3RcMykr1tby4M35CJ3mfE8IoaLmpGaH6Ih1Xdt0Qhwj8ztB7-3swwZnSMuEh5imGADbGCyEOenZx4DNDkOe_bTeosNL8kGn3Que8VzcLJsB61KaoFoy4B4evYVP6KPTY4bT_X6C_n77-uf2R3X36_vP25u7yjaSzhVQ04m2la20pHECWE2AMcNrwZiwlFEKPbeOs8ZYzTvGqdAGpOHOma4vwAm6XnW3i5mgX82PapuK67RTUXv170vwg9rERyUFE4yKInCxF0jxYSnjqslnC-OoA8Qlq5p3nHLCSVfQ8xXd6BGUDy4WRfuMq5tClf8VjSzU5TtUWT1MvvwvOF_q7zXYFHNO4F7dU6KeI1dr5GofeWn4_HbmV_wl4AJ8WYG4bP8n9gTm17nF</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Pattnaik, Siddharth</creator><creator>Das, Dipankar</creator><creator>Venkatesan, Varun Akur</creator><creator>Rai, Aayush</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4136-5180</orcidid></search><sort><creationdate>2023</creationdate><title>Predicting serum hormone concentration by estimation of urinary hormones through a home-use device</title><author>Pattnaik, Siddharth ; Das, Dipankar ; Venkatesan, Varun Akur ; Rai, Aayush</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c491t-e1b6855959c04f8e320e33b728338c1311ed7cf734bca763718abe9b7ffb6dc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Care and treatment</topic><topic>Evaluation</topic><topic>Fertility</topic><topic>Original</topic><topic>Patient monitoring equipment</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pattnaik, Siddharth</creatorcontrib><creatorcontrib>Das, Dipankar</creatorcontrib><creatorcontrib>Venkatesan, Varun Akur</creatorcontrib><creatorcontrib>Rai, Aayush</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human reproduction open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pattnaik, Siddharth</au><au>Das, Dipankar</au><au>Venkatesan, Varun Akur</au><au>Rai, Aayush</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predicting serum hormone concentration by estimation of urinary hormones through a home-use device</atitle><jtitle>Human reproduction open</jtitle><addtitle>Hum Reprod Open</addtitle><date>2023</date><risdate>2023</risdate><volume>2023</volume><issue>1</issue><spage>hoac058</spage><epage>hoac058</epage><pages>hoac058-hoac058</pages><issn>2399-3529</issn><eissn>2399-3529</eissn><abstract>Abstract
STUDY QUESTION
Can a home-use device be used to predict serum hormone levels?
SUMMARY ANSWER
A home-use device can predict urinary hormone values which are well-correlated to serum concentrations of respective hormones and hence can be used as a proxy for serum measurements.
WHAT IS KNOWN ALREADY
Home-use devices that predict ovulation are calibrated against the actual day of ovulation. However, the correlation of any quantitative system to serum hormone concentrations has not been established.
STUDY DESIGN, SIZE, DURATION
A total of 73 data points obtained from 20 participants across different phases of the menstrual cycle, i.e. bleeding days, follicular phase and luteal phase were used to establish the correlation between serum hormones and urinary metabolite values. Single data points from 20 random users were used to assess the correlation established.
PARTICIPANTS/MATERIALS, SETTING, METHODS
Participants were women in the fertile age groups and only current users of the home-use device. Selection was done based on inclusion and exclusion criteria. Blood hormones were tested using chemiluminescent immunoassays and urinary measurements were taken on the home-use device at home.
MAIN RESULTS AND THE ROLE OF CHANCE
Serum estradiol (E2), progesterone (P4) and LH were correlated with urinary estrone-3-glucuronide (E3G), pregnanediol glucuronide (PdG) and LH with an R2 of 0.96, 0.95 and 0.98, respectively. Repredicted serum concentration obtained by using the correlation equation had a correlation of 0.92, 0.94 and 0.93 in unknown samples.
LIMITATIONS, REASONS FOR CAUTION
The study was designed to include women who have normal cycle lengths regularly; therefore, the values obtained were in the normal range. Certain infertility conditions may cause the values to be higher and correlation in such cases needs to be established.
WIDER IMPLICATIONS OF THE FINDINGS
The results of this study imply a new tool that can be used by fertility specialists as a proxy for blood tests whenever required. Extended study on this system can enable its use in assisted reproductive techniques as well.
STUDY FUNDING/COMPETING INTEREST(S)
No funding was received for this study. S.P. and D.D. are employees of the research and development division of Samplytics Technologies Pvt. Ltd. which is a forwarder for Inito Inc., USA. A.R. and V.A.V. are co-founders of Inito Inc., USA.
TRIAL REGISTRATION NUMBER
The trial was registered at the International Standard Randomised Controlled Trial Number (ISRCTN) registry (Identifier: ISRCTN15534557).</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>36654688</pmid><doi>10.1093/hropen/hoac058</doi><orcidid>https://orcid.org/0000-0003-4136-5180</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2399-3529 |
| ispartof | Human reproduction open, 2023, Vol.2023 (1), p.hoac058-hoac058 |
| issn | 2399-3529 2399-3529 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9838318 |
| source | Oxford Journals Open Access Collection; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Care and treatment Evaluation Fertility Original Patient monitoring equipment |
| title | Predicting serum hormone concentration by estimation of urinary hormones through a home-use device |
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