Organelle-Specific Mechanisms in Crosstalk between Apoptosis and Ferroptosis
Apoptosis has been extensively studied, whereas ferroptosis is a newly discovered form of regulated cell death that involves iron-dependent accumulations of lipid hydroperoxides. While these two cell death mechanisms were initially believed to be mutually exclusive, recent studies have revealed cell...
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| Veröffentlicht in: | Oxidative medicine and cellular longevity 2023, Vol.2023, p.3400147-14 |
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| creator | Wu, Peiyao Zhang, Xiaoyue Duan, Dingyu Zhao, Lei |
| description | Apoptosis has been extensively studied, whereas ferroptosis is a newly discovered form of regulated cell death that involves iron-dependent accumulations of lipid hydroperoxides. While these two cell death mechanisms were initially believed to be mutually exclusive, recent studies have revealed cellular contexts requiring a balanced interaction between them. Numerous subcellular sites and signaling molecules within these sites are involved in both processes, either as modules or switches that allow cells to choose on how to proceed. The close relationships between apoptosis and ferroptosis, as well as the possibility of switching from one to the other, are described in this review. To understand the crosstalk between apoptosis and ferroptosis, various organelle-specific mechanisms must be analyzed and compared. The ability to switch apoptosis to ferroptosis by targeting cellular organelles has a great potential in cancer therapy. |
| doi_str_mv | 10.1155/2023/3400147 |
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While these two cell death mechanisms were initially believed to be mutually exclusive, recent studies have revealed cellular contexts requiring a balanced interaction between them. Numerous subcellular sites and signaling molecules within these sites are involved in both processes, either as modules or switches that allow cells to choose on how to proceed. The close relationships between apoptosis and ferroptosis, as well as the possibility of switching from one to the other, are described in this review. To understand the crosstalk between apoptosis and ferroptosis, various organelle-specific mechanisms must be analyzed and compared. The ability to switch apoptosis to ferroptosis by targeting cellular organelles has a great potential in cancer therapy.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2023/3400147</identifier><identifier>PMID: 36644574</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Apoptosis ; Atherosclerosis ; Cancer ; Cell Death ; Cells ; Cytoplasm ; Disease ; Ferroptosis ; Inflammatory bowel disease ; Iron - metabolism ; Ligands ; Lipid peroxidation ; Lipids ; Lymphoma ; Morphology ; Organelles - metabolism ; Oxidative stress ; Proteins ; Review ; Tumor necrosis factor-TNF</subject><ispartof>Oxidative medicine and cellular longevity, 2023, Vol.2023, p.3400147-14</ispartof><rights>Copyright © 2023 Peiyao Wu et al.</rights><rights>Copyright © 2023 Peiyao Wu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2023 Peiyao Wu et al. 2023</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c514t-5b1db500965a313a9d347d709fbcaa4e3150ba1cb0b2f73f5a8519aa46d6b5563</citedby><cites>FETCH-LOGICAL-c514t-5b1db500965a313a9d347d709fbcaa4e3150ba1cb0b2f73f5a8519aa46d6b5563</cites><orcidid>0000-0002-9612-3114 ; 0000-0002-5263-2267 ; 0000-0003-3978-7165 ; 0000-0003-4077-533X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836800/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836800/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36644574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Malaguti, Marco</contributor><contributor>Marco Malaguti</contributor><creatorcontrib>Wu, Peiyao</creatorcontrib><creatorcontrib>Zhang, Xiaoyue</creatorcontrib><creatorcontrib>Duan, Dingyu</creatorcontrib><creatorcontrib>Zhao, Lei</creatorcontrib><title>Organelle-Specific Mechanisms in Crosstalk between Apoptosis and Ferroptosis</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Apoptosis has been extensively studied, whereas ferroptosis is a newly discovered form of regulated cell death that involves iron-dependent accumulations of lipid hydroperoxides. 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The ability to switch apoptosis to ferroptosis by targeting cellular organelles has a great potential in cancer therapy.</description><subject>Apoptosis</subject><subject>Atherosclerosis</subject><subject>Cancer</subject><subject>Cell Death</subject><subject>Cells</subject><subject>Cytoplasm</subject><subject>Disease</subject><subject>Ferroptosis</subject><subject>Inflammatory bowel disease</subject><subject>Iron - metabolism</subject><subject>Ligands</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Lymphoma</subject><subject>Morphology</subject><subject>Organelles - metabolism</subject><subject>Oxidative stress</subject><subject>Proteins</subject><subject>Review</subject><subject>Tumor necrosis factor-TNF</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc1Lw0AQxRdR_KjePEvAi6Cxs9mPNBehFKtCpQf1vOxuNu1quom7qcX_3oTWoh48zQzz4zHzHkKnGK4xZqyfQEL6hAJgmu6gQ5zRJIYso7vbHuAAHYXwCsBJQvE-OiCcU8pSeogmUz-TzpSliZ9qo21hdfRo9Fw6GxYhsi4a-SqERpZvkTLNyhgXDeuqbqpgQyRdHo2N95v5GO0VsgzmZFN76GV8-zy6jyfTu4fRcBJrhmkTM4VzxQAyziTBRGY5oWmeQlYoLSU1BDNQEmsFKilSUjA5YDhrNzznijFOeuhmrVsv1cLk2rjGy1LU3i6k_xSVtOL3xtm5mFUfIhsQPgBoBS42Ar56X5rQiIUNunWhtaJaBpGknANPE5K06Pkf9LVaete-11GMDTgn3UVXa0p3bnlTbI_BILqYRBeT2MTU4mc_H9jC37m0wOUamFuXy5X9X-4LTmmacQ</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Wu, Peiyao</creator><creator>Zhang, Xiaoyue</creator><creator>Duan, Dingyu</creator><creator>Zhao, Lei</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9612-3114</orcidid><orcidid>https://orcid.org/0000-0002-5263-2267</orcidid><orcidid>https://orcid.org/0000-0003-3978-7165</orcidid><orcidid>https://orcid.org/0000-0003-4077-533X</orcidid></search><sort><creationdate>2023</creationdate><title>Organelle-Specific Mechanisms in Crosstalk between Apoptosis and Ferroptosis</title><author>Wu, Peiyao ; 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| subjects | Apoptosis Atherosclerosis Cancer Cell Death Cells Cytoplasm Disease Ferroptosis Inflammatory bowel disease Iron - metabolism Ligands Lipid peroxidation Lipids Lymphoma Morphology Organelles - metabolism Oxidative stress Proteins Review Tumor necrosis factor-TNF |
| title | Organelle-Specific Mechanisms in Crosstalk between Apoptosis and Ferroptosis |
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