Immunological and psychosocial functioning in parents of children with cancer
Purpose Research has shown that parents of children with cancer exhibit an altered immune profile compared to parents of healthy children, reflective of increased susceptibility to illness. These parents are also at risk for poorer psychosocial outcomes and quality of life. The current study compare...
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| Veröffentlicht in: | Supportive care in cancer 2022-04, Vol.30 (4), p.3379-3388 |
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| container_title | Supportive care in cancer |
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| creator | Agbayani, Crystle-Joie Tucker, Jo A. Nelson, Edward L. Martinez, Freddy Cortes, Haydee Khoury, Dina Kain, Zeev N. Lin, Carol Torno, Lilibeth Fortier, Michelle A |
| description | Purpose
Research has shown that parents of children with cancer exhibit an altered immune profile compared to parents of healthy children, reflective of increased susceptibility to illness. These parents are also at risk for poorer psychosocial outcomes and quality of life. The current study compares peripheral blood cell analyses and psychosocial self-reports from parents of children being treated for cancer (
n
= 21) to parents of healthy children (
n
= 30).
Methods
A blood sample was drawn from parents to analyze immune profiles. Parents also completed the Perceived Stress Scale (PSS), Medical Outcomes Study Short Form-36 (MOS), and Patient-Reported Outcomes Measurement Information System Short Form v1.0 Emotional Distress-Anxiety 8a, and Emotional Distress-Depression 8a (PROMIS). Mann–Whitney
U
tests and independent samples
t
-tests were conducted to examine differences in outcomes between parent groups.
Results
Parents of children with cancer exhibited higher monocyte percentages in their peripheral blood compared to peers with healthy children. Parents of children with cancer also reported poorer psychosocial outcomes: higher perceived stress, higher anxiety and depression symptoms, more role disability resulting from emotional problems, poorer general and mental health, and poorer social functioning.
Conclusion
These findings support research that has shown a direct effect of chronic stress on the immune system. Symptoms reported by parents of children with cancer indicate unmet psychosocial needs that could potentially affect long-term health. Given the central role of parents in their children’s cancer care, it is compelling to address and work to improve parent immunological and psychosocial well-being. |
| doi_str_mv | 10.1007/s00520-021-06770-0 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9833860</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A694276781</galeid><sourcerecordid>A694276781</sourcerecordid><originalsourceid>FETCH-LOGICAL-c541t-1383703a2a3d7160ebd28356d100aacf19cb2661981c98da985a569d11aa690e3</originalsourceid><addsrcrecordid>eNp9kk1vFSEUhomxsdfqH3BhJnHTzVTgMHxsTJqmapOabto14QIzl2YGrjBT038v11tba4xhARye83JeOAi9I_iEYCw-Fow7iltMSYu5EHX1Aq0IA2gFgHqJVlgx0jLoukP0upRbjIkQHX2FDoEpxSTHK_TtYpqWmMY0BGvGxkTXbMu93aSSbKiBfol2DimGODQhNluTfZxLk_rGbsLo6q75EeZNY020Pr9BB70Zi3_7MB-hm8_n12df28urLxdnp5et7RiZWwISBAZDDThBOPZrRyV03FVbxtieKLumnBMliVXSGSU703HlCDGGK-zhCH3a626X9eSdrTVlM-ptDpPJ9zqZoJ-fxLDRQ7rTSgJU31Xg-EEgp--LL7OeQrF-HE30aSmaciIpMFCsoh_-Qm_TkmO1VynAjKgO8BM1mNHrEPtU77U7UX3KFaOCC0kqdfIPqg7np2BT9H2o8WcJdJ9gcyol-_7RI8F61wR63wS6NoH-1QR6V8v7P1_nMeX3r1cA9kCpR3Hw-cnSf2R_AkYau4I</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2630419530</pqid></control><display><type>article</type><title>Immunological and psychosocial functioning in parents of children with cancer</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Agbayani, Crystle-Joie ; Tucker, Jo A. ; Nelson, Edward L. ; Martinez, Freddy ; Cortes, Haydee ; Khoury, Dina ; Kain, Zeev N. ; Lin, Carol ; Torno, Lilibeth ; Fortier, Michelle A</creator><creatorcontrib>Agbayani, Crystle-Joie ; Tucker, Jo A. ; Nelson, Edward L. ; Martinez, Freddy ; Cortes, Haydee ; Khoury, Dina ; Kain, Zeev N. ; Lin, Carol ; Torno, Lilibeth ; Fortier, Michelle A</creatorcontrib><description>Purpose
Research has shown that parents of children with cancer exhibit an altered immune profile compared to parents of healthy children, reflective of increased susceptibility to illness. These parents are also at risk for poorer psychosocial outcomes and quality of life. The current study compares peripheral blood cell analyses and psychosocial self-reports from parents of children being treated for cancer (
n
= 21) to parents of healthy children (
n
= 30).
Methods
A blood sample was drawn from parents to analyze immune profiles. Parents also completed the Perceived Stress Scale (PSS), Medical Outcomes Study Short Form-36 (MOS), and Patient-Reported Outcomes Measurement Information System Short Form v1.0 Emotional Distress-Anxiety 8a, and Emotional Distress-Depression 8a (PROMIS). Mann–Whitney
U
tests and independent samples
t
-tests were conducted to examine differences in outcomes between parent groups.
Results
Parents of children with cancer exhibited higher monocyte percentages in their peripheral blood compared to peers with healthy children. Parents of children with cancer also reported poorer psychosocial outcomes: higher perceived stress, higher anxiety and depression symptoms, more role disability resulting from emotional problems, poorer general and mental health, and poorer social functioning.
Conclusion
These findings support research that has shown a direct effect of chronic stress on the immune system. Symptoms reported by parents of children with cancer indicate unmet psychosocial needs that could potentially affect long-term health. Given the central role of parents in their children’s cancer care, it is compelling to address and work to improve parent immunological and psychosocial well-being.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-021-06770-0</identifier><identifier>PMID: 34994860</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anxiety - epidemiology ; Anxiety - psychology ; Blood ; Cancer ; Children ; Comparative analysis ; Depression, Mental ; Disease susceptibility ; Humans ; Immunology ; Medicine ; Medicine & Public Health ; Mental Health ; Neoplasms ; Nursing ; Nursing Research ; Oncology ; Original Article ; Pain Medicine ; Parents & parenting ; Parents - psychology ; Pediatrics ; Psychological aspects ; Psychosocial Functioning ; Quality of Life - psychology ; Rehabilitation Medicine ; Risk factors ; Stress ; Stress (Psychology) ; Well being</subject><ispartof>Supportive care in cancer, 2022-04, Vol.30 (4), p.3379-3388</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>COPYRIGHT 2022 Springer</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-1383703a2a3d7160ebd28356d100aacf19cb2661981c98da985a569d11aa690e3</citedby><cites>FETCH-LOGICAL-c541t-1383703a2a3d7160ebd28356d100aacf19cb2661981c98da985a569d11aa690e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-021-06770-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-021-06770-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34994860$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Agbayani, Crystle-Joie</creatorcontrib><creatorcontrib>Tucker, Jo A.</creatorcontrib><creatorcontrib>Nelson, Edward L.</creatorcontrib><creatorcontrib>Martinez, Freddy</creatorcontrib><creatorcontrib>Cortes, Haydee</creatorcontrib><creatorcontrib>Khoury, Dina</creatorcontrib><creatorcontrib>Kain, Zeev N.</creatorcontrib><creatorcontrib>Lin, Carol</creatorcontrib><creatorcontrib>Torno, Lilibeth</creatorcontrib><creatorcontrib>Fortier, Michelle A</creatorcontrib><title>Immunological and psychosocial functioning in parents of children with cancer</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
Research has shown that parents of children with cancer exhibit an altered immune profile compared to parents of healthy children, reflective of increased susceptibility to illness. These parents are also at risk for poorer psychosocial outcomes and quality of life. The current study compares peripheral blood cell analyses and psychosocial self-reports from parents of children being treated for cancer (
n
= 21) to parents of healthy children (
n
= 30).
Methods
A blood sample was drawn from parents to analyze immune profiles. Parents also completed the Perceived Stress Scale (PSS), Medical Outcomes Study Short Form-36 (MOS), and Patient-Reported Outcomes Measurement Information System Short Form v1.0 Emotional Distress-Anxiety 8a, and Emotional Distress-Depression 8a (PROMIS). Mann–Whitney
U
tests and independent samples
t
-tests were conducted to examine differences in outcomes between parent groups.
Results
Parents of children with cancer exhibited higher monocyte percentages in their peripheral blood compared to peers with healthy children. Parents of children with cancer also reported poorer psychosocial outcomes: higher perceived stress, higher anxiety and depression symptoms, more role disability resulting from emotional problems, poorer general and mental health, and poorer social functioning.
Conclusion
These findings support research that has shown a direct effect of chronic stress on the immune system. Symptoms reported by parents of children with cancer indicate unmet psychosocial needs that could potentially affect long-term health. Given the central role of parents in their children’s cancer care, it is compelling to address and work to improve parent immunological and psychosocial well-being.</description><subject>Anxiety - epidemiology</subject><subject>Anxiety - psychology</subject><subject>Blood</subject><subject>Cancer</subject><subject>Children</subject><subject>Comparative analysis</subject><subject>Depression, Mental</subject><subject>Disease susceptibility</subject><subject>Humans</subject><subject>Immunology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mental Health</subject><subject>Neoplasms</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Parents & parenting</subject><subject>Parents - psychology</subject><subject>Pediatrics</subject><subject>Psychological aspects</subject><subject>Psychosocial Functioning</subject><subject>Quality of Life - psychology</subject><subject>Rehabilitation Medicine</subject><subject>Risk factors</subject><subject>Stress</subject><subject>Stress (Psychology)</subject><subject>Well being</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kk1vFSEUhomxsdfqH3BhJnHTzVTgMHxsTJqmapOabto14QIzl2YGrjBT038v11tba4xhARye83JeOAi9I_iEYCw-Fow7iltMSYu5EHX1Aq0IA2gFgHqJVlgx0jLoukP0upRbjIkQHX2FDoEpxSTHK_TtYpqWmMY0BGvGxkTXbMu93aSSbKiBfol2DimGODQhNluTfZxLk_rGbsLo6q75EeZNY020Pr9BB70Zi3_7MB-hm8_n12df28urLxdnp5et7RiZWwISBAZDDThBOPZrRyV03FVbxtieKLumnBMliVXSGSU703HlCDGGK-zhCH3a626X9eSdrTVlM-ptDpPJ9zqZoJ-fxLDRQ7rTSgJU31Xg-EEgp--LL7OeQrF-HE30aSmaciIpMFCsoh_-Qm_TkmO1VynAjKgO8BM1mNHrEPtU77U7UX3KFaOCC0kqdfIPqg7np2BT9H2o8WcJdJ9gcyol-_7RI8F61wR63wS6NoH-1QR6V8v7P1_nMeX3r1cA9kCpR3Hw-cnSf2R_AkYau4I</recordid><startdate>20220401</startdate><enddate>20220401</enddate><creator>Agbayani, Crystle-Joie</creator><creator>Tucker, Jo A.</creator><creator>Nelson, Edward L.</creator><creator>Martinez, Freddy</creator><creator>Cortes, Haydee</creator><creator>Khoury, Dina</creator><creator>Kain, Zeev N.</creator><creator>Lin, Carol</creator><creator>Torno, Lilibeth</creator><creator>Fortier, Michelle A</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220401</creationdate><title>Immunological and psychosocial functioning in parents of children with cancer</title><author>Agbayani, Crystle-Joie ; Tucker, Jo A. ; Nelson, Edward L. ; Martinez, Freddy ; Cortes, Haydee ; Khoury, Dina ; Kain, Zeev N. ; Lin, Carol ; Torno, Lilibeth ; Fortier, Michelle A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c541t-1383703a2a3d7160ebd28356d100aacf19cb2661981c98da985a569d11aa690e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anxiety - epidemiology</topic><topic>Anxiety - psychology</topic><topic>Blood</topic><topic>Cancer</topic><topic>Children</topic><topic>Comparative analysis</topic><topic>Depression, Mental</topic><topic>Disease susceptibility</topic><topic>Humans</topic><topic>Immunology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mental Health</topic><topic>Neoplasms</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Parents & parenting</topic><topic>Parents - psychology</topic><topic>Pediatrics</topic><topic>Psychological aspects</topic><topic>Psychosocial Functioning</topic><topic>Quality of Life - psychology</topic><topic>Rehabilitation Medicine</topic><topic>Risk factors</topic><topic>Stress</topic><topic>Stress (Psychology)</topic><topic>Well being</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agbayani, Crystle-Joie</creatorcontrib><creatorcontrib>Tucker, Jo A.</creatorcontrib><creatorcontrib>Nelson, Edward L.</creatorcontrib><creatorcontrib>Martinez, Freddy</creatorcontrib><creatorcontrib>Cortes, Haydee</creatorcontrib><creatorcontrib>Khoury, Dina</creatorcontrib><creatorcontrib>Kain, Zeev N.</creatorcontrib><creatorcontrib>Lin, Carol</creatorcontrib><creatorcontrib>Torno, Lilibeth</creatorcontrib><creatorcontrib>Fortier, Michelle A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agbayani, Crystle-Joie</au><au>Tucker, Jo A.</au><au>Nelson, Edward L.</au><au>Martinez, Freddy</au><au>Cortes, Haydee</au><au>Khoury, Dina</au><au>Kain, Zeev N.</au><au>Lin, Carol</au><au>Torno, Lilibeth</au><au>Fortier, Michelle A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunological and psychosocial functioning in parents of children with cancer</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2022-04-01</date><risdate>2022</risdate><volume>30</volume><issue>4</issue><spage>3379</spage><epage>3388</epage><pages>3379-3388</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
Research has shown that parents of children with cancer exhibit an altered immune profile compared to parents of healthy children, reflective of increased susceptibility to illness. These parents are also at risk for poorer psychosocial outcomes and quality of life. The current study compares peripheral blood cell analyses and psychosocial self-reports from parents of children being treated for cancer (
n
= 21) to parents of healthy children (
n
= 30).
Methods
A blood sample was drawn from parents to analyze immune profiles. Parents also completed the Perceived Stress Scale (PSS), Medical Outcomes Study Short Form-36 (MOS), and Patient-Reported Outcomes Measurement Information System Short Form v1.0 Emotional Distress-Anxiety 8a, and Emotional Distress-Depression 8a (PROMIS). Mann–Whitney
U
tests and independent samples
t
-tests were conducted to examine differences in outcomes between parent groups.
Results
Parents of children with cancer exhibited higher monocyte percentages in their peripheral blood compared to peers with healthy children. Parents of children with cancer also reported poorer psychosocial outcomes: higher perceived stress, higher anxiety and depression symptoms, more role disability resulting from emotional problems, poorer general and mental health, and poorer social functioning.
Conclusion
These findings support research that has shown a direct effect of chronic stress on the immune system. Symptoms reported by parents of children with cancer indicate unmet psychosocial needs that could potentially affect long-term health. Given the central role of parents in their children’s cancer care, it is compelling to address and work to improve parent immunological and psychosocial well-being.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34994860</pmid><doi>10.1007/s00520-021-06770-0</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Supportive care in cancer, 2022-04, Vol.30 (4), p.3379-3388 |
| issn | 0941-4355 1433-7339 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9833860 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Anxiety - epidemiology Anxiety - psychology Blood Cancer Children Comparative analysis Depression, Mental Disease susceptibility Humans Immunology Medicine Medicine & Public Health Mental Health Neoplasms Nursing Nursing Research Oncology Original Article Pain Medicine Parents & parenting Parents - psychology Pediatrics Psychological aspects Psychosocial Functioning Quality of Life - psychology Rehabilitation Medicine Risk factors Stress Stress (Psychology) Well being |
| title | Immunological and psychosocial functioning in parents of children with cancer |
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