P2Y12 receptor antagonism inhibits proliferation, migration and leads to autophagy of glioblastoma cells

Glioblastoma (GBM) is the most aggressive and lethal among the primary brain tumors, with a low survival rate and resistance to radio and chemotherapy. The P2Y 12 is an adenosine diphosphate (ADP) purinergic chemoreceptor, found mainly in platelets. In cancer cells, its activation has been described...

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Veröffentlicht in:	Purinergic signalling 2022-12, Vol.18 (4), p.481-494
Hauptverfasser:	Vargas, Pedro, Scheffel, Thamiris Becker, Diz, Fernando Mendonça, Rockenbach, Liliana, Grave, Nathália, Cappellari, Angélica Regina, Kist, Luiza Wilges, Bogo, Maurício Reis, Thomé, Marcos Paulo, Leal, Gabriel Fernandes, de Fraga Dias, Amanda, Figueiró, Fabrício, Filippi-Chiela, Eduardo Cremonese, Lenz, Guido, Morrone, Fernanda Bueno
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Autophagy Biomedical and Life Sciences Biomedicine Brain cancer Brain tumors Cancer Research Cell activation Cell adhesion Cell cycle Cell death Cell migration Cell proliferation Chemotherapy Colonies Glioblastoma Glioblastoma cells Glioma Human Physiology Hydrolysis Metastases Neurosciences Original Original Article Pharmacology/Toxicology Tumors
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