High fever in myelin oligodendrocyte glycoprotein-associated disorder (MOGAD): A diagnostic challenge
The phenotypic spectrum of myelin oligodendrocyte glycoprotein (MOG)-IgG associated disorders (MOGAD) has broadened in the past few years, and atypical phenotypes are increasingly recognized. Febrile meningoencephalitis has rarely been reported as a feature of MOGAD and represents a diagnostic chall...
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| Veröffentlicht in: | Multiple sclerosis journal - experimental, translational and clinical translational and clinical, 2023-01, Vol.9 (1), p.20552173221148911 |
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| container_start_page | 20552173221148911 |
| container_title | Multiple sclerosis journal - experimental, translational and clinical |
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| creator | Azar, Chadi Akiki, Grace Haddad, Sara F Kerbage, Anthony Haddad, Fady Macaron, Gabrielle |
| description | The phenotypic spectrum of myelin oligodendrocyte glycoprotein (MOG)-IgG associated disorders (MOGAD) has broadened in the past few years, and atypical phenotypes are increasingly recognized. Febrile meningoencephalitis has rarely been reported as a feature of MOGAD and represents a diagnostic challenge. We report the case of 24-year-old women with high-grade fever, meningoencephalomyelitis, and persistently positive MOG-IgG, for whom an extensive infectious work-up was negative and who responded to high-dose intravenous methylprednisolone. The full clinical spectrum of MOGAD is yet to be completely elucidated. In patients presenting with febrile meningoencephalitis, MOG-IgG testing should be considered particularly if infectious work-up is negative. |
| doi_str_mv | 10.1177/20552173221148911 |
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Febrile meningoencephalitis has rarely been reported as a feature of MOGAD and represents a diagnostic challenge. We report the case of 24-year-old women with high-grade fever, meningoencephalomyelitis, and persistently positive MOG-IgG, for whom an extensive infectious work-up was negative and who responded to high-dose intravenous methylprednisolone. The full clinical spectrum of MOGAD is yet to be completely elucidated. 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| subjects | Case Report Encephalitis Fever Genotype & phenotype Glycoproteins Medical diagnosis Meningitis |
| title | High fever in myelin oligodendrocyte glycoprotein-associated disorder (MOGAD): A diagnostic challenge |
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