Radiopharmaceuticals heat anti-tumor immunity
Radiopharmaceutical therapy (RPT) has proven to be an effective cancer treatment with minimal toxicity. With several RPT agents approved by FDA, the remarkable potential of this therapy is now being recognized, and the anti-tumor immunity induced by RPT is beginning to be noticed. This review evalua...
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| Veröffentlicht in: | Theranostics 2023, Vol.13 (2), p.767-786 |
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| container_title | Theranostics |
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| creator | Sun, Qi Li, Jiyuan Ding, Zexuan Liu, Zhibo |
| description | Radiopharmaceutical therapy (RPT) has proven to be an effective cancer treatment with minimal toxicity. With several RPT agents approved by FDA, the remarkable potential of this therapy is now being recognized, and the anti-tumor immunity induced by RPT is beginning to be noticed. This review evaluates the potential of RPT for immune activation, including promoting the release of danger associated-molecular pattern molecules that recruit inflammatory cells into the tumor microenvironment, and activating antigen-presenting cells and cytotoxic T cells. We also discuss the progress of combining RPT with immunotherapy to increase efficacy. |
| doi_str_mv | 10.7150/thno.79806 |
| format | Article |
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We also discuss the progress of combining RPT with immunotherapy to increase efficacy.</description><identifier>ISSN: 1838-7640</identifier><identifier>EISSN: 1838-7640</identifier><identifier>DOI: 10.7150/thno.79806</identifier><identifier>PMID: 36632233</identifier><language>eng</language><publisher>Australia: Ivyspring International Publisher Pty Ltd</publisher><subject>Antigens ; Apoptosis ; Cancer therapies ; Cells ; Cytokines ; Cytotoxicity ; DNA damage ; Hot Temperature ; Humans ; Immune system ; Immunotherapy ; Lymphocytes ; Neoplasms - therapy ; Peptides ; Proteins ; Radiation therapy ; Radiopharmaceuticals - therapeutic use ; Review ; T-Lymphocytes, Cytotoxic ; Tumor Microenvironment ; Tumor necrosis factor-TNF ; Tumors</subject><ispartof>Theranostics, 2023, Vol.13 (2), p.767-786</ispartof><rights>The author(s).</rights><rights>2023. This work is published under https://creativecommons.org/licenses/by/4.0/ (the “License”). 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We also discuss the progress of combining RPT with immunotherapy to increase efficacy.</description><subject>Antigens</subject><subject>Apoptosis</subject><subject>Cancer therapies</subject><subject>Cells</subject><subject>Cytokines</subject><subject>Cytotoxicity</subject><subject>DNA damage</subject><subject>Hot Temperature</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunotherapy</subject><subject>Lymphocytes</subject><subject>Neoplasms - therapy</subject><subject>Peptides</subject><subject>Proteins</subject><subject>Radiation therapy</subject><subject>Radiopharmaceuticals - therapeutic use</subject><subject>Review</subject><subject>T-Lymphocytes, Cytotoxic</subject><subject>Tumor Microenvironment</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumors</subject><issn>1838-7640</issn><issn>1838-7640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpVUEtLAzEYDKLYUnvxB8iCN2FrNsnmcRGk-IKCIHoO2STrpnQ3NZsV-u9NbS31u3wDM8wMA8BlAWesKOFtbDo_Y4JDegLGBcc8Z5TA0yM8AtO-X8J0BCJRiHMwwpRihDAeg_xNGefXjQqt0naITqtVnzVWxUx10eVxaH3IXNsOnYubC3BWJ95O938CPh4f3ufP-eL16WV-v8g1gTTmQpdUMEQohgJVtCqJEEgQwbGGZc21JYqbIiFaGaOs4dTUDNamgEhxJTCegLud73qoWmu07WJQK7kOrlVhI71y8j_TuUZ--m-ZIiDBPBlc7w2C_xpsH-XSD6FLnSViDMGSUSyS6man0sH3fbD1IaGAcruu3K4rf9dN4qvjTgfp35b4B3gSdcU</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Sun, Qi</creator><creator>Li, Jiyuan</creator><creator>Ding, Zexuan</creator><creator>Liu, Zhibo</creator><general>Ivyspring International Publisher Pty Ltd</general><general>Ivyspring International Publisher</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>2023</creationdate><title>Radiopharmaceuticals heat anti-tumor immunity</title><author>Sun, Qi ; Li, Jiyuan ; Ding, Zexuan ; Liu, Zhibo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-9c56972463092b6b5499294983c05f8ce4a8d15f86bddaed86df70fd102a8a933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Antigens</topic><topic>Apoptosis</topic><topic>Cancer therapies</topic><topic>Cells</topic><topic>Cytokines</topic><topic>Cytotoxicity</topic><topic>DNA damage</topic><topic>Hot Temperature</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunotherapy</topic><topic>Lymphocytes</topic><topic>Neoplasms - therapy</topic><topic>Peptides</topic><topic>Proteins</topic><topic>Radiation therapy</topic><topic>Radiopharmaceuticals - therapeutic use</topic><topic>Review</topic><topic>T-Lymphocytes, Cytotoxic</topic><topic>Tumor Microenvironment</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Qi</creatorcontrib><creatorcontrib>Li, Jiyuan</creatorcontrib><creatorcontrib>Ding, Zexuan</creatorcontrib><creatorcontrib>Liu, Zhibo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Theranostics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Qi</au><au>Li, Jiyuan</au><au>Ding, Zexuan</au><au>Liu, Zhibo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Radiopharmaceuticals heat anti-tumor immunity</atitle><jtitle>Theranostics</jtitle><addtitle>Theranostics</addtitle><date>2023</date><risdate>2023</risdate><volume>13</volume><issue>2</issue><spage>767</spage><epage>786</epage><pages>767-786</pages><issn>1838-7640</issn><eissn>1838-7640</eissn><abstract>Radiopharmaceutical therapy (RPT) has proven to be an effective cancer treatment with minimal toxicity. 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| subjects | Antigens Apoptosis Cancer therapies Cells Cytokines Cytotoxicity DNA damage Hot Temperature Humans Immune system Immunotherapy Lymphocytes Neoplasms - therapy Peptides Proteins Radiation therapy Radiopharmaceuticals - therapeutic use Review T-Lymphocytes, Cytotoxic Tumor Microenvironment Tumor necrosis factor-TNF Tumors |
| title | Radiopharmaceuticals heat anti-tumor immunity |
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