Mechanism of Schwann cells in diabetic peripheral neuropathy: A review
Diabetic peripheral neuropathy (DPN) is the most common neuropathy in the world, mainly manifested as bilateral symmetry numbness, pain or paresthesia, with a high rate of disability and mortality. Schwann cells (SCs), derived from neural ridge cells, are the largest number of glial cells in the per...
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| Veröffentlicht in: | Medicine (Baltimore) 2023-01, Vol.102 (1), p.e32653-e32653 |
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| creator | Li, Jingjing Guan, Ruiqian Pan, Limin |
| description | Diabetic peripheral neuropathy (DPN) is the most common neuropathy in the world, mainly manifested as bilateral symmetry numbness, pain or paresthesia, with a high rate of disability and mortality. Schwann cells (SCs), derived from neural ridge cells, are the largest number of glial cells in the peripheral nervous system, and play an important role in DPN. Studies have found that SCs are closely related to the pathogenesis of DPN, such as oxidative stress, endoplasmic reticulum stress, inflammation, impaired neurotrophic support and dyslipidemia. This article reviews the mechanism of SCs in DPN. |
| doi_str_mv | 10.1097/MD.0000000000032653 |
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Schwann cells (SCs), derived from neural ridge cells, are the largest number of glial cells in the peripheral nervous system, and play an important role in DPN. Studies have found that SCs are closely related to the pathogenesis of DPN, such as oxidative stress, endoplasmic reticulum stress, inflammation, impaired neurotrophic support and dyslipidemia. 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This article reviews the mechanism of SCs in DPN.</description><subject>Diabetes Mellitus - pathology</subject><subject>Diabetic Neuropathies</subject><subject>Humans</subject><subject>Narrative Review</subject><subject>Neuroglia - pathology</subject><subject>Oxidative Stress</subject><subject>Schwann Cells - pathology</subject><issn>1536-5964</issn><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1P3DAQhq2KqlDoL6hU-cglMP6IHfdQCS1flVhxoJwtrzMhptkk2Amr_ffNdoEutQ8eye88884MIV8ZnDAw-nR-fgL_juAqFx_IAcuFynKj5N5OvE8-p_QIwITm8hPZF0qBLnR-QC7n6GvXhrSkXUXvfL1ybUs9Nk2ioaVlcAscgqc9xtDXGF1DWxxj17uhXn-nZzTic8DVEflYuSbhl5f3kNxfXvyaXWc3t1c_Z2c3mZc5QFYo9KJwsiwRvDbccVkZnbvKF1J6XXIuFCtwAd5xbVjJwZRGCFEtnMpRoTgkP7bcflwssfTYDpMl28ewdHFtOxfs-5821Pahe7am4Ga6E-D4BRC7pxHTYJchbdp1LXZjslwrZgohBUxSsZX62KUUsXorw8BuNmDn5_b_DUxZ33YdvuW8jnwSyK1g1TUDxvS7GVcYbY2uGeq_vHyaTMaBC2CgINugQfwB3BeRTg</recordid><startdate>20230106</startdate><enddate>20230106</enddate><creator>Li, Jingjing</creator><creator>Guan, Ruiqian</creator><creator>Pan, Limin</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8604-1721</orcidid></search><sort><creationdate>20230106</creationdate><title>Mechanism of Schwann cells in diabetic peripheral neuropathy: A review</title><author>Li, Jingjing ; Guan, Ruiqian ; Pan, Limin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4500-86ec38a4dde0c792a24f975afc844c7d223618eb0ca2791d209d9333fba65e6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Diabetes Mellitus - pathology</topic><topic>Diabetic Neuropathies</topic><topic>Humans</topic><topic>Narrative Review</topic><topic>Neuroglia - pathology</topic><topic>Oxidative Stress</topic><topic>Schwann Cells - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Jingjing</creatorcontrib><creatorcontrib>Guan, Ruiqian</creatorcontrib><creatorcontrib>Pan, Limin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Jingjing</au><au>Guan, Ruiqian</au><au>Pan, Limin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanism of Schwann cells in diabetic peripheral neuropathy: A review</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2023-01-06</date><risdate>2023</risdate><volume>102</volume><issue>1</issue><spage>e32653</spage><epage>e32653</epage><pages>e32653-e32653</pages><issn>1536-5964</issn><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Diabetic peripheral neuropathy (DPN) is the most common neuropathy in the world, mainly manifested as bilateral symmetry numbness, pain or paresthesia, with a high rate of disability and mortality. Schwann cells (SCs), derived from neural ridge cells, are the largest number of glial cells in the peripheral nervous system, and play an important role in DPN. Studies have found that SCs are closely related to the pathogenesis of DPN, such as oxidative stress, endoplasmic reticulum stress, inflammation, impaired neurotrophic support and dyslipidemia. This article reviews the mechanism of SCs in DPN.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>36607875</pmid><doi>10.1097/MD.0000000000032653</doi><orcidid>https://orcid.org/0000-0002-8604-1721</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1536-5964 |
| ispartof | Medicine (Baltimore), 2023-01, Vol.102 (1), p.e32653-e32653 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Diabetes Mellitus - pathology Diabetic Neuropathies Humans Narrative Review Neuroglia - pathology Oxidative Stress Schwann Cells - pathology |
| title | Mechanism of Schwann cells in diabetic peripheral neuropathy: A review |
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