The Pathology of Experimental Aerosolized Monkeypox Virus Infection in Cynomolgus Monkeys (Macaca fascicularis)

Cynomolgus monkeys (Macaca fascicularis) were exposed by fine-particle aerosol to lethal doses of monkeypox virus, Zaire strain. Death, attributable to fibrinonecrotic bronchopneumonia, occurred 9 to 17 days postexposure. Lower airway epithelium served as the principal target for primary infection....

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Veröffentlicht in:	Laboratory investigation 2001-12, Vol.81 (12), p.1581-1600
Hauptverfasser:	Zaucha, Gary M, Jahrling, Peter B, Geisbert, Thomas W, Swearengen, James R, Hensley, Lisa
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols Animals Antigens, Viral - analysis Biological and medical sciences Cadaver Cynomolgus Experimental viral diseases and models Immunohistochemistry In Situ Nick-End Labeling Infectious diseases Laboratory Medicine Macaca fascicularis Medical sciences Medicine Medicine & Public Health Microscopy, Electron Monkeypox virus Monkeypox virus - immunology Monkeypox virus - isolation & purification Mpox Pathology Poxviridae Infections - immunology Poxviridae Infections - pathology Poxviridae Infections - virology Respiratory System - pathology Viral diseases
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