Biomolecular Interactions of Cytotoxic Ruthenium Compounds with Thiosemicarbazone or Benzothiazole Schiff Base Chelates

Herein we illustrate the formation and characterization of new paramagnetic ruthenium compounds, trans‐P‐[RuCl(PPh3)2(pmt)]Cl (1) (Hpmt=1‐((pyridin‐2‐yl)methylene)thiosemicarbazide), trans‐P‐[RuCl(PPh3)2(tmc)]Cl (2) (Htmc=1‐((thiophen‐2‐yl)methylene)thiosemicarbazide) and a diamagnetic ruthenium com...

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Veröffentlicht in:	ChemMedChem 2022-10, Vol.17 (20), p.e202200444-n/a
Hauptverfasser:	Maikoo, Sanam, Xulu, Bheki, Mambanda, Allen, Mkhwanazi, Ntando, Davison, Candace, Mare, Jo‐Anne, Booysen, Irvin Noel
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Benzothiazole Benzothiazoles - pharmacology biomolecular interactions Cancer Chelates Chloride ions Chlorides Coordination Complexes - chemistry Coordination Complexes - toxicity Coordination compounds Cytotoxicity Deoxyribonucleic acid Diamagnetism Dimethyl Sulfoxide DNA DNA - chemistry DNA topoisomerase DNA Topoisomerases, Type I - metabolism Electrophoresis Gel electrophoresis Imines Intercalating Agents Metal complexes Metal compounds Methylene Blue Organometallic Compounds - chemistry Phosphates Plasmids Ruthenium Ruthenium - chemistry Ruthenium - pharmacology Ruthenium compounds Ruthenium Compounds - chemistry Ruthenium Compounds - metabolism Schiff Bases - pharmacology Substitution reactions Thiosemicarbazides thiosemicarbazone Thiosemicarbazones - pharmacology Tumor cell lines
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