Donepezil inhibits neuromuscular junctional acetylcholinesterase and enhances synaptic transmission and function in isolated skeletal muscle

Background and Purpose Donepezil, a piperidine inhibitor of acetylcholinesterase (AChE) prescribed for treatment of Alzheimer's disease, has adverse neuromuscular effects in humans, including requirement for higher concentrations of non‐depolarising neuromuscular blockers during surgery. Here,...

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Veröffentlicht in:	British journal of pharmacology 2022-12, Vol.179 (24), p.5273-5289
Hauptverfasser:	Redman, Robert R., Mackenzie, Harry, Dissanayake, Kosala N., Eddleston, Michael, Ribchester, Richard R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine Acetylcholine receptors (nicotinic) Acetylcholinesterase Acetylcholinesterase - metabolism Acetylcholinesterase - pharmacology Alzheimer's disease Animals anticholinesterase Calcium (intracellular) Donepezil Donepezil - pharmacology endplate potential Humans Mice Motor endplates Muscle contraction Muscle, Skeletal - metabolism Neurodegenerative diseases neuromuscular block neuromuscular junction Neuromuscular Junction - metabolism Neuromuscular junctions Piperidine Skeletal muscle Synaptic depression Synaptic Transmission
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