Mechanism of Lys6 poly-ubiquitin specificity by the L. pneumophila deubiquitinase LotA

The versatility of ubiquitination to control vast domains of eukaryotic biology is due, in part, to diversification through differently linked poly-ubiquitin chains. Deciphering signaling roles for some chain types, including those linked via K6, has been stymied by a lack of specificity among the i...

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Veröffentlicht in:	Molecular cell 2023-01, Vol.83 (1), p.105-120.e5
Hauptverfasser:	Warren, Gus D., Kitao, Tomoe, Franklin, Tyler G., Nguyen, Justine V., Geurink, Paul P., Kubori, Tomoko, Nagai, Hiroki, Pruneda, Jonathan N.
Format:	Artikel
Sprache:	eng
Schlagworte:	bacterial effector Bacterial Proteins - genetics Bacterial Proteins - metabolism deubiquitinase Deubiquitinating Enzymes - metabolism Legionella pneumophila Legionella pneumophila - genetics Legionella pneumophila - metabolism Polyubiquitin - genetics Polyubiquitin - metabolism ubiquitin Ubiquitin - genetics Ubiquitin - metabolism Ubiquitination VCP/p97/Cdc48
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