The MHC Motif Atlas: a database of MHC binding specificities and ligands
The highly polymorphic Major Histocompatibility Complex (MHC) genes are responsible for the binding and cell surface presentation of pathogen or cancer specific T-cell epitopes. This process is fundamental for eliciting T-cell recognition of infected or malignant cells. Epitopes displayed on MHC mol...
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Veröffentlicht in: | Nucleic acids research 2023-01, Vol.51 (D1), p.D428-D437 |
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creator | Tadros, Daniel M Eggenschwiler, Simon Racle, Julien Gfeller, David |
description | The highly polymorphic Major Histocompatibility Complex (MHC) genes are responsible for the binding and cell surface presentation of pathogen or cancer specific T-cell epitopes. This process is fundamental for eliciting T-cell recognition of infected or malignant cells. Epitopes displayed on MHC molecules further provide therapeutic targets for personalized cancer vaccines or adoptive T-cell therapy. To help visualizing, analyzing and comparing the different binding specificities of MHC molecules, we developed the MHC Motif Atlas (http://mhcmotifatlas.org/). This database contains information about thousands of class I and class II MHC molecules, including binding motifs, peptide length distributions, motifs of phosphorylated ligands, multiple specificities or links to X-ray crystallography structures. The database further enables users to download curated datasets of MHC ligands. By combining intuitive visualization of the main binding properties of MHC molecules together with access to more than a million ligands, the MHC Motif Atlas provides a central resource to analyze and interpret the binding specificities of MHC molecules. |
doi_str_mv | 10.1093/nar/gkac965 |
format | Article |
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By combining intuitive visualization of the main binding properties of MHC molecules together with access to more than a million ligands, the MHC Motif Atlas provides a central resource to analyze and interpret the binding specificities of MHC molecules.</description><subject>Atlases as Topic</subject><subject>Database Issue</subject><subject>Epitopes, T-Lymphocyte</subject><subject>Histocompatibility Antigens Class II</subject><subject>Ligands</subject><subject>Major Histocompatibility Complex</subject><subject>Peptides - chemistry</subject><subject>Protein Binding</subject><issn>0305-1048</issn><issn>1362-4962</issn><issn>1362-4962</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkM9LwzAYhoMobk5P3iVHQeqSJmkbD8IY6oQNL_McvuZHF-3a2bSC_711m0NP7-F9eL-PB6FLSm4pkWxcQTMu3kHLRByhIWVJHHGZxMdoSBgRESU8G6CzEN4IoZwKfooGLGE0i1kyRLPlyuLFbIoXdesdnrQlhDsM2EALOQSLa7etc18ZXxU4bKz2zmvfehswVAaXvugjnKMTB2WwF_scodfHh-V0Fs1fnp6nk3mkWUbbyEoDOtWMGU1AOuEkAwdSWpqnhjiTMppnkKXESK21A5NklkPMiXMQ5yZhI3S_2910-doabau2gVJtGr-G5kvV4NX_pvIrVdSfSmaxECnvB673A0390dnQqrUP2pYlVLbugor7F4hI6Ra92aG6qUNorDucoUT9uFe9e7V339NXfz87sL-y2TdiL4I2</recordid><startdate>20230106</startdate><enddate>20230106</enddate><creator>Tadros, Daniel M</creator><creator>Eggenschwiler, Simon</creator><creator>Racle, Julien</creator><creator>Gfeller, David</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1271-6941</orcidid></search><sort><creationdate>20230106</creationdate><title>The MHC Motif Atlas: a database of MHC binding specificities and ligands</title><author>Tadros, Daniel M ; Eggenschwiler, Simon ; Racle, Julien ; Gfeller, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-e9dac7c33dc0a9f5f93afa99e1b7d0fd731b8a870d9cccfad68e4a240ffa2bd63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Atlases as Topic</topic><topic>Database Issue</topic><topic>Epitopes, T-Lymphocyte</topic><topic>Histocompatibility Antigens Class II</topic><topic>Ligands</topic><topic>Major Histocompatibility Complex</topic><topic>Peptides - chemistry</topic><topic>Protein Binding</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tadros, Daniel M</creatorcontrib><creatorcontrib>Eggenschwiler, Simon</creatorcontrib><creatorcontrib>Racle, Julien</creatorcontrib><creatorcontrib>Gfeller, David</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nucleic acids research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tadros, Daniel M</au><au>Eggenschwiler, Simon</au><au>Racle, Julien</au><au>Gfeller, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The MHC Motif Atlas: a database of MHC binding specificities and ligands</atitle><jtitle>Nucleic acids research</jtitle><addtitle>Nucleic Acids Res</addtitle><date>2023-01-06</date><risdate>2023</risdate><volume>51</volume><issue>D1</issue><spage>D428</spage><epage>D437</epage><pages>D428-D437</pages><issn>0305-1048</issn><issn>1362-4962</issn><eissn>1362-4962</eissn><abstract>The highly polymorphic Major Histocompatibility Complex (MHC) genes are responsible for the binding and cell surface presentation of pathogen or cancer specific T-cell epitopes. 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subjects | Atlases as Topic Database Issue Epitopes, T-Lymphocyte Histocompatibility Antigens Class II Ligands Major Histocompatibility Complex Peptides - chemistry Protein Binding |
title | The MHC Motif Atlas: a database of MHC binding specificities and ligands |
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