The MHC Motif Atlas: a database of MHC binding specificities and ligands

The highly polymorphic Major Histocompatibility Complex (MHC) genes are responsible for the binding and cell surface presentation of pathogen or cancer specific T-cell epitopes. This process is fundamental for eliciting T-cell recognition of infected or malignant cells. Epitopes displayed on MHC mol...

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Veröffentlicht in:Nucleic acids research 2023-01, Vol.51 (D1), p.D428-D437
Hauptverfasser: Tadros, Daniel M, Eggenschwiler, Simon, Racle, Julien, Gfeller, David
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container_issue D1
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container_title Nucleic acids research
container_volume 51
creator Tadros, Daniel M
Eggenschwiler, Simon
Racle, Julien
Gfeller, David
description The highly polymorphic Major Histocompatibility Complex (MHC) genes are responsible for the binding and cell surface presentation of pathogen or cancer specific T-cell epitopes. This process is fundamental for eliciting T-cell recognition of infected or malignant cells. Epitopes displayed on MHC molecules further provide therapeutic targets for personalized cancer vaccines or adoptive T-cell therapy. To help visualizing, analyzing and comparing the different binding specificities of MHC molecules, we developed the MHC Motif Atlas (http://mhcmotifatlas.org/). This database contains information about thousands of class I and class II MHC molecules, including binding motifs, peptide length distributions, motifs of phosphorylated ligands, multiple specificities or links to X-ray crystallography structures. The database further enables users to download curated datasets of MHC ligands. By combining intuitive visualization of the main binding properties of MHC molecules together with access to more than a million ligands, the MHC Motif Atlas provides a central resource to analyze and interpret the binding specificities of MHC molecules.
doi_str_mv 10.1093/nar/gkac965
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source Oxford Journals Open Access Collection; MEDLINE; Full-Text Journals in Chemistry (Open access); PubMed Central; Directory of Open Access Journals
subjects Atlases as Topic
Database Issue
Epitopes, T-Lymphocyte
Histocompatibility Antigens Class II
Ligands
Major Histocompatibility Complex
Peptides - chemistry
Protein Binding
title The MHC Motif Atlas: a database of MHC binding specificities and ligands
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