Therapeutic targeting of inflammation in hypertension: from novel mechanisms to translational perspective

Abstract Both animal models and human observational and genetic studies have shown that immune and inflammatory mechanisms play a key role in hypertension and its complications. We review the effects of immunomodulatory interventions on blood pressure, target organ damage, and cardiovascular risk in...

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Veröffentlicht in:	Cardiovascular research 2021-11, Vol.117 (13), p.2589-2609
Hauptverfasser:	Murray, Eleanor C, Nosalski, Ryszard, MacRitchie, Neil, Tomaszewski, Maciej, Maffia, Pasquale, Harrison, David G, Guzik, Tomasz J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - therapeutic use Antihypertensive Agents - therapeutic use Blood Pressure - drug effects Editor's Choice Humans Hypertension - drug therapy Hypertension - genetics Hypertension - immunology Hypertension - physiopathology Immunomodulating Agents - therapeutic use Immunosuppressive Agents - therapeutic use Inflammation - drug therapy Inflammation - genetics Inflammation - immunology Inflammation - physiopathology Inflammation Mediators - antagonists & inhibitors Inflammation Mediators - immunology Invited Spotlight Reviews Molecular Targeted Therapy Signal Transduction Translational Research, Biomedical Tumor Necrosis Factor Inhibitors - therapeutic use
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