Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial
This double-blind, randomized clinical trial aimed to evaluate the efficacy and safety of B-3 (BB-3) for reducing body fat. Healthy individuals were randomized into the BB-3 or placebo group (1:1). Dual-energy X-ray absorptiometry was used to evaluate body fat reduction objectively. In the BB-3 grou...
Gespeichert in:
| Veröffentlicht in: | Nutrients 2022-12, Vol.15 (1), p.28 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 28 |
| container_title | Nutrients |
| container_volume | 15 |
| creator | Sung, Hyun Kyung Youn, Sang Jun Choi, Yong Eun, Sang Won Shin, Seon Mi |
| description | This double-blind, randomized clinical trial aimed to evaluate the efficacy and safety of
B-3 (BB-3) for reducing body fat. Healthy individuals were randomized into the BB-3 or placebo group (1:1). Dual-energy X-ray absorptiometry was used to evaluate body fat reduction objectively. In the BB-3 group, body weight was lower than before BB-3 ingestion. Regarding waist circumference, hip circumference, and waist/hip circumference ratio, waist circumference and hip circumference were lower in the BB-3 group than in the placebo group at 12 weeks; the waist/hip circumference ratio was found to decrease at each visit in the BB-3 group, although there was no significant difference in the amount of change after 12 weeks. BB-3 did not cause any severe adverse reactions. Body fat was significantly lower in the BB-3 group than in the placebo group. In conclusion, ingesting BB-3 significantly reduces body weight, waist circumference, and hip circumference. Thus, BB-3 is safe and effective for reducing body fat. |
| doi_str_mv | 10.3390/nu15010028 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9824586</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2761191425</sourcerecordid><originalsourceid>FETCH-LOGICAL-c406t-f392f4a830a82508e3bdcb3d72fc7c1c1ded4f6434458b82ff2156f732762473</originalsourceid><addsrcrecordid>eNpdkVtr3DAQhUVJaUKal_6AIuhLKXGrm2W5D4Hs5tJCoCXsu5ClUaIgW1vZXkh_fbS5NY1epGE-nZnDQegDJV85b8m3YaY1oYQw9QbtMdKwSkrBd168d9HBON6Q7WlII_k7tMulpLVUcg9tFsnd4jMz4Utws51CGvCp92AnnDxeBB9c6oydIIe5x12GDeBFxb_jY3xpBpf68BfcIT5JcxehWsQwlOp3NBa6hJepX5tsplA-LUsrWBPxKgcT36O33sQRDh7vfbQ6O10tf1QXv85_Lo8vKiuInCrPW-aFUZwYxWqigHfOdtw1zNvGUksdOOGLRyFq1SnmPSu-fMNZI5lo-D46epBdz10PzsIwZRP1Oofe5FudTND_d4Zwra_SRreKFUVZBD4_CuT0Z4Zx0n0YLcRoBkjzqMsc2irRsu2sT6_QmzTnobi7p2hLBasL9eWBsjmNYwb_vAwlehuo_hdogT--XP8ZfYqP3wEgyZo_</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2761191425</pqid></control><display><type>article</type><title>Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Sung, Hyun Kyung ; Youn, Sang Jun ; Choi, Yong ; Eun, Sang Won ; Shin, Seon Mi</creator><creatorcontrib>Sung, Hyun Kyung ; Youn, Sang Jun ; Choi, Yong ; Eun, Sang Won ; Shin, Seon Mi</creatorcontrib><description>This double-blind, randomized clinical trial aimed to evaluate the efficacy and safety of
B-3 (BB-3) for reducing body fat. Healthy individuals were randomized into the BB-3 or placebo group (1:1). Dual-energy X-ray absorptiometry was used to evaluate body fat reduction objectively. In the BB-3 group, body weight was lower than before BB-3 ingestion. Regarding waist circumference, hip circumference, and waist/hip circumference ratio, waist circumference and hip circumference were lower in the BB-3 group than in the placebo group at 12 weeks; the waist/hip circumference ratio was found to decrease at each visit in the BB-3 group, although there was no significant difference in the amount of change after 12 weeks. BB-3 did not cause any severe adverse reactions. Body fat was significantly lower in the BB-3 group than in the placebo group. In conclusion, ingesting BB-3 significantly reduces body weight, waist circumference, and hip circumference. Thus, BB-3 is safe and effective for reducing body fat.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu15010028</identifier><identifier>PMID: 36615686</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adipose Tissue ; Bifidobacterium breve ; Body fat ; Body Mass Index ; Body Weight ; Cardiovascular disease ; Cholesterol ; Clinical trials ; Diabetes ; Double-Blind Method ; Double-blind studies ; Drug dosages ; Dual energy X-ray absorptiometry ; Food ; Hospitals ; Humans ; Ingestion ; Intervention ; Medical research ; Obesity ; Obesity - drug therapy ; Placebos ; Probiotics ; Silica ; Weight reduction</subject><ispartof>Nutrients, 2022-12, Vol.15 (1), p.28</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c406t-f392f4a830a82508e3bdcb3d72fc7c1c1ded4f6434458b82ff2156f732762473</citedby><cites>FETCH-LOGICAL-c406t-f392f4a830a82508e3bdcb3d72fc7c1c1ded4f6434458b82ff2156f732762473</cites><orcidid>0000-0002-0366-1707 ; 0000-0002-9270-0199 ; 0000-0002-2592-7043 ; 0000-0003-1660-2973</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824586/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9824586/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36615686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sung, Hyun Kyung</creatorcontrib><creatorcontrib>Youn, Sang Jun</creatorcontrib><creatorcontrib>Choi, Yong</creatorcontrib><creatorcontrib>Eun, Sang Won</creatorcontrib><creatorcontrib>Shin, Seon Mi</creatorcontrib><title>Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>This double-blind, randomized clinical trial aimed to evaluate the efficacy and safety of
B-3 (BB-3) for reducing body fat. Healthy individuals were randomized into the BB-3 or placebo group (1:1). Dual-energy X-ray absorptiometry was used to evaluate body fat reduction objectively. In the BB-3 group, body weight was lower than before BB-3 ingestion. Regarding waist circumference, hip circumference, and waist/hip circumference ratio, waist circumference and hip circumference were lower in the BB-3 group than in the placebo group at 12 weeks; the waist/hip circumference ratio was found to decrease at each visit in the BB-3 group, although there was no significant difference in the amount of change after 12 weeks. BB-3 did not cause any severe adverse reactions. Body fat was significantly lower in the BB-3 group than in the placebo group. In conclusion, ingesting BB-3 significantly reduces body weight, waist circumference, and hip circumference. Thus, BB-3 is safe and effective for reducing body fat.</description><subject>Adipose Tissue</subject><subject>Bifidobacterium breve</subject><subject>Body fat</subject><subject>Body Mass Index</subject><subject>Body Weight</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Clinical trials</subject><subject>Diabetes</subject><subject>Double-Blind Method</subject><subject>Double-blind studies</subject><subject>Drug dosages</subject><subject>Dual energy X-ray absorptiometry</subject><subject>Food</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Ingestion</subject><subject>Intervention</subject><subject>Medical research</subject><subject>Obesity</subject><subject>Obesity - drug therapy</subject><subject>Placebos</subject><subject>Probiotics</subject><subject>Silica</subject><subject>Weight reduction</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkVtr3DAQhUVJaUKal_6AIuhLKXGrm2W5D4Hs5tJCoCXsu5ClUaIgW1vZXkh_fbS5NY1epGE-nZnDQegDJV85b8m3YaY1oYQw9QbtMdKwSkrBd168d9HBON6Q7WlII_k7tMulpLVUcg9tFsnd4jMz4Utws51CGvCp92AnnDxeBB9c6oydIIe5x12GDeBFxb_jY3xpBpf68BfcIT5JcxehWsQwlOp3NBa6hJepX5tsplA-LUsrWBPxKgcT36O33sQRDh7vfbQ6O10tf1QXv85_Lo8vKiuInCrPW-aFUZwYxWqigHfOdtw1zNvGUksdOOGLRyFq1SnmPSu-fMNZI5lo-D46epBdz10PzsIwZRP1Oofe5FudTND_d4Zwra_SRreKFUVZBD4_CuT0Z4Zx0n0YLcRoBkjzqMsc2irRsu2sT6_QmzTnobi7p2hLBasL9eWBsjmNYwb_vAwlehuo_hdogT--XP8ZfYqP3wEgyZo_</recordid><startdate>20221221</startdate><enddate>20221221</enddate><creator>Sung, Hyun Kyung</creator><creator>Youn, Sang Jun</creator><creator>Choi, Yong</creator><creator>Eun, Sang Won</creator><creator>Shin, Seon Mi</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0366-1707</orcidid><orcidid>https://orcid.org/0000-0002-9270-0199</orcidid><orcidid>https://orcid.org/0000-0002-2592-7043</orcidid><orcidid>https://orcid.org/0000-0003-1660-2973</orcidid></search><sort><creationdate>20221221</creationdate><title>Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial</title><author>Sung, Hyun Kyung ; Youn, Sang Jun ; Choi, Yong ; Eun, Sang Won ; Shin, Seon Mi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c406t-f392f4a830a82508e3bdcb3d72fc7c1c1ded4f6434458b82ff2156f732762473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adipose Tissue</topic><topic>Bifidobacterium breve</topic><topic>Body fat</topic><topic>Body Mass Index</topic><topic>Body Weight</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Clinical trials</topic><topic>Diabetes</topic><topic>Double-Blind Method</topic><topic>Double-blind studies</topic><topic>Drug dosages</topic><topic>Dual energy X-ray absorptiometry</topic><topic>Food</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Ingestion</topic><topic>Intervention</topic><topic>Medical research</topic><topic>Obesity</topic><topic>Obesity - drug therapy</topic><topic>Placebos</topic><topic>Probiotics</topic><topic>Silica</topic><topic>Weight reduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sung, Hyun Kyung</creatorcontrib><creatorcontrib>Youn, Sang Jun</creatorcontrib><creatorcontrib>Choi, Yong</creatorcontrib><creatorcontrib>Eun, Sang Won</creatorcontrib><creatorcontrib>Shin, Seon Mi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Nutrients</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sung, Hyun Kyung</au><au>Youn, Sang Jun</au><au>Choi, Yong</au><au>Eun, Sang Won</au><au>Shin, Seon Mi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial</atitle><jtitle>Nutrients</jtitle><addtitle>Nutrients</addtitle><date>2022-12-21</date><risdate>2022</risdate><volume>15</volume><issue>1</issue><spage>28</spage><pages>28-</pages><issn>2072-6643</issn><eissn>2072-6643</eissn><abstract>This double-blind, randomized clinical trial aimed to evaluate the efficacy and safety of
B-3 (BB-3) for reducing body fat. Healthy individuals were randomized into the BB-3 or placebo group (1:1). Dual-energy X-ray absorptiometry was used to evaluate body fat reduction objectively. In the BB-3 group, body weight was lower than before BB-3 ingestion. Regarding waist circumference, hip circumference, and waist/hip circumference ratio, waist circumference and hip circumference were lower in the BB-3 group than in the placebo group at 12 weeks; the waist/hip circumference ratio was found to decrease at each visit in the BB-3 group, although there was no significant difference in the amount of change after 12 weeks. BB-3 did not cause any severe adverse reactions. Body fat was significantly lower in the BB-3 group than in the placebo group. In conclusion, ingesting BB-3 significantly reduces body weight, waist circumference, and hip circumference. Thus, BB-3 is safe and effective for reducing body fat.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36615686</pmid><doi>10.3390/nu15010028</doi><orcidid>https://orcid.org/0000-0002-0366-1707</orcidid><orcidid>https://orcid.org/0000-0002-9270-0199</orcidid><orcidid>https://orcid.org/0000-0002-2592-7043</orcidid><orcidid>https://orcid.org/0000-0003-1660-2973</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6643 |
| ispartof | Nutrients, 2022-12, Vol.15 (1), p.28 |
| issn | 2072-6643 2072-6643 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9824586 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Adipose Tissue Bifidobacterium breve Body fat Body Mass Index Body Weight Cardiovascular disease Cholesterol Clinical trials Diabetes Double-Blind Method Double-blind studies Drug dosages Dual energy X-ray absorptiometry Food Hospitals Humans Ingestion Intervention Medical research Obesity Obesity - drug therapy Placebos Probiotics Silica Weight reduction |
| title | Body Fat Reduction Effect of Bifidobacterium breve B-3: A Randomized, Double-Blind, Placebo Comparative Clinical Trial |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T06%3A00%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Body%20Fat%20Reduction%20Effect%20of%20Bifidobacterium%20breve%20B-3:%20A%20Randomized,%20Double-Blind,%20Placebo%20Comparative%20Clinical%20Trial&rft.jtitle=Nutrients&rft.au=Sung,%20Hyun%20Kyung&rft.date=2022-12-21&rft.volume=15&rft.issue=1&rft.spage=28&rft.pages=28-&rft.issn=2072-6643&rft.eissn=2072-6643&rft_id=info:doi/10.3390/nu15010028&rft_dat=%3Cproquest_pubme%3E2761191425%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2761191425&rft_id=info:pmid/36615686&rfr_iscdi=true |