Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids
Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditions, such as Alzheimer's disease, schizophren...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2022-12, Vol.24 (1), p.507 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 1 |
| container_start_page | 507 |
| container_title | International journal of molecular sciences |
| container_volume | 24 |
| creator | Szczurowska, Ewa Szánti-Pintér, Eszter Chetverikov, Nikolai Randáková, Alena Kudová, Eva Jakubík, Jan |
| description | Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditions, such as Alzheimer's disease, schizophrenia, addiction, epilepsy, or depression. Muscarinic receptors are allosterically modulated by neurosteroids and steroid hormones at physiologically relevant concentrations. In this review, we focus on the modulation of muscarinic receptors by neurosteroids and steroid hormones in the context of diseases and disorders of the central nervous system. Further, we propose the potential use of neuroactive steroids in the development of pharmacotherapeutics for these diseases and conditions. |
| doi_str_mv | 10.3390/ijms24010507 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9820491</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2761981441</sourcerecordid><originalsourceid>FETCH-LOGICAL-c384t-e97a76d2e878dffb9993c08afb968eae2ec0a2b26a31a671a4a3621f8bceec7a3</originalsourceid><addsrcrecordid>eNpVkUlPwzAQhS0Eomw3zshHDhS8pE58QUIVm8RyKJytiTNpXSU22AlS_z1BhaqcZqT36c0bPUJOObuUUrMrt2yTyBhnE5bvkAOeCTFmTOW7W_uIHKa0ZExIMdH7ZCSV4lJP-AGZP4eqb6BzwdNQ0-c-WYjOO0tnbu6haZyfU-dpt0A6Rd9FaOgLxq_QJzpbpQ5bWq7orMMYXEUfQmyDx0TBVwPWx5DWSjomezU0CU9-5xF5v7t9mz6Mn17vH6c3T2Mri6wbo84hV5XAIi-qui611tKyAoZNFQgo0DIQpVAgOaicQwZSCV4XpUW0Ocgjcr32_ejLFiu7jmw-omshrkwAZ_4r3i3MPHwZXQiWaT4YnP8axPDZY-pM65LFpgGPw9NG5IrrgmfZD3qxRu3wZ4pYb85wZn66MdvdDPjZdrQN_FeG_AYaNo41</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2761981441</pqid></control><display><type>article</type><title>Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><creator>Szczurowska, Ewa ; Szánti-Pintér, Eszter ; Chetverikov, Nikolai ; Randáková, Alena ; Kudová, Eva ; Jakubík, Jan</creator><creatorcontrib>Szczurowska, Ewa ; Szánti-Pintér, Eszter ; Chetverikov, Nikolai ; Randáková, Alena ; Kudová, Eva ; Jakubík, Jan</creatorcontrib><description>Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditions, such as Alzheimer's disease, schizophrenia, addiction, epilepsy, or depression. Muscarinic receptors are allosterically modulated by neurosteroids and steroid hormones at physiologically relevant concentrations. In this review, we focus on the modulation of muscarinic receptors by neurosteroids and steroid hormones in the context of diseases and disorders of the central nervous system. Further, we propose the potential use of neuroactive steroids in the development of pharmacotherapeutics for these diseases and conditions.</description><identifier>ISSN: 1422-0067</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms24010507</identifier><identifier>PMID: 36613951</identifier><language>eng</language><publisher>Switzerland: MDPI</publisher><subject>Central Nervous System ; Cholinergic Agents ; Hormones ; Neurosteroids - pharmacology ; Receptors, Muscarinic ; Review ; Steroids - pharmacology ; Steroids - physiology</subject><ispartof>International journal of molecular sciences, 2022-12, Vol.24 (1), p.507</ispartof><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-e97a76d2e878dffb9993c08afb968eae2ec0a2b26a31a671a4a3621f8bceec7a3</citedby><cites>FETCH-LOGICAL-c384t-e97a76d2e878dffb9993c08afb968eae2ec0a2b26a31a671a4a3621f8bceec7a3</cites><orcidid>0000-0002-1737-1487 ; 0000-0001-7131-5948</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820491/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9820491/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36613951$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szczurowska, Ewa</creatorcontrib><creatorcontrib>Szánti-Pintér, Eszter</creatorcontrib><creatorcontrib>Chetverikov, Nikolai</creatorcontrib><creatorcontrib>Randáková, Alena</creatorcontrib><creatorcontrib>Kudová, Eva</creatorcontrib><creatorcontrib>Jakubík, Jan</creatorcontrib><title>Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditions, such as Alzheimer's disease, schizophrenia, addiction, epilepsy, or depression. Muscarinic receptors are allosterically modulated by neurosteroids and steroid hormones at physiologically relevant concentrations. In this review, we focus on the modulation of muscarinic receptors by neurosteroids and steroid hormones in the context of diseases and disorders of the central nervous system. Further, we propose the potential use of neuroactive steroids in the development of pharmacotherapeutics for these diseases and conditions.</description><subject>Central Nervous System</subject><subject>Cholinergic Agents</subject><subject>Hormones</subject><subject>Neurosteroids - pharmacology</subject><subject>Receptors, Muscarinic</subject><subject>Review</subject><subject>Steroids - pharmacology</subject><subject>Steroids - physiology</subject><issn>1422-0067</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUlPwzAQhS0Eomw3zshHDhS8pE58QUIVm8RyKJytiTNpXSU22AlS_z1BhaqcZqT36c0bPUJOObuUUrMrt2yTyBhnE5bvkAOeCTFmTOW7W_uIHKa0ZExIMdH7ZCSV4lJP-AGZP4eqb6BzwdNQ0-c-WYjOO0tnbu6haZyfU-dpt0A6Rd9FaOgLxq_QJzpbpQ5bWq7orMMYXEUfQmyDx0TBVwPWx5DWSjomezU0CU9-5xF5v7t9mz6Mn17vH6c3T2Mri6wbo84hV5XAIi-qui611tKyAoZNFQgo0DIQpVAgOaicQwZSCV4XpUW0Ocgjcr32_ejLFiu7jmw-omshrkwAZ_4r3i3MPHwZXQiWaT4YnP8axPDZY-pM65LFpgGPw9NG5IrrgmfZD3qxRu3wZ4pYb85wZn66MdvdDPjZdrQN_FeG_AYaNo41</recordid><startdate>20221228</startdate><enddate>20221228</enddate><creator>Szczurowska, Ewa</creator><creator>Szánti-Pintér, Eszter</creator><creator>Chetverikov, Nikolai</creator><creator>Randáková, Alena</creator><creator>Kudová, Eva</creator><creator>Jakubík, Jan</creator><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1737-1487</orcidid><orcidid>https://orcid.org/0000-0001-7131-5948</orcidid></search><sort><creationdate>20221228</creationdate><title>Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids</title><author>Szczurowska, Ewa ; Szánti-Pintér, Eszter ; Chetverikov, Nikolai ; Randáková, Alena ; Kudová, Eva ; Jakubík, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-e97a76d2e878dffb9993c08afb968eae2ec0a2b26a31a671a4a3621f8bceec7a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Central Nervous System</topic><topic>Cholinergic Agents</topic><topic>Hormones</topic><topic>Neurosteroids - pharmacology</topic><topic>Receptors, Muscarinic</topic><topic>Review</topic><topic>Steroids - pharmacology</topic><topic>Steroids - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szczurowska, Ewa</creatorcontrib><creatorcontrib>Szánti-Pintér, Eszter</creatorcontrib><creatorcontrib>Chetverikov, Nikolai</creatorcontrib><creatorcontrib>Randáková, Alena</creatorcontrib><creatorcontrib>Kudová, Eva</creatorcontrib><creatorcontrib>Jakubík, Jan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szczurowska, Ewa</au><au>Szánti-Pintér, Eszter</au><au>Chetverikov, Nikolai</au><au>Randáková, Alena</au><au>Kudová, Eva</au><au>Jakubík, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2022-12-28</date><risdate>2022</risdate><volume>24</volume><issue>1</issue><spage>507</spage><pages>507-</pages><issn>1422-0067</issn><eissn>1422-0067</eissn><abstract>Muscarinic acetylcholine receptors expressed in the central nervous system mediate various functions, including cognition, memory, or reward. Therefore, muscarinic receptors represent potential pharmacological targets for various diseases and conditions, such as Alzheimer's disease, schizophrenia, addiction, epilepsy, or depression. Muscarinic receptors are allosterically modulated by neurosteroids and steroid hormones at physiologically relevant concentrations. In this review, we focus on the modulation of muscarinic receptors by neurosteroids and steroid hormones in the context of diseases and disorders of the central nervous system. Further, we propose the potential use of neuroactive steroids in the development of pharmacotherapeutics for these diseases and conditions.</abstract><cop>Switzerland</cop><pub>MDPI</pub><pmid>36613951</pmid><doi>10.3390/ijms24010507</doi><orcidid>https://orcid.org/0000-0002-1737-1487</orcidid><orcidid>https://orcid.org/0000-0001-7131-5948</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2022-12, Vol.24 (1), p.507 |
| issn | 1422-0067 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9820491 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Central Nervous System Cholinergic Agents Hormones Neurosteroids - pharmacology Receptors, Muscarinic Review Steroids - pharmacology Steroids - physiology |
| title | Modulation of Muscarinic Signalling in the Central Nervous System by Steroid Hormones and Neurosteroids |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-27T17%3A20%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Modulation%20of%20Muscarinic%20Signalling%20in%20the%20Central%20Nervous%20System%20by%20Steroid%20Hormones%20and%20Neurosteroids&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Szczurowska,%20Ewa&rft.date=2022-12-28&rft.volume=24&rft.issue=1&rft.spage=507&rft.pages=507-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms24010507&rft_dat=%3Cproquest_pubme%3E2761981441%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2761981441&rft_id=info:pmid/36613951&rfr_iscdi=true |