Loss of SORCS2 is Associated with Neuronal DNA Double-Strand Breaks

SORCS2 is one of five proteins that constitute the Vps10p-domain receptor family. Members of this family play important roles in cellular processes linked to neuronal survival, differentiation and function. Genetic and functional studies implicate SORCS2 in cognitive function, as well as in neurodeg...

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Veröffentlicht in:	Cellular and molecular neurobiology 2023-01, Vol.43 (1), p.237-249
Hauptverfasser:	Gospodinova, Katerina O., Olsen, Ditte, Kaas, Mathias, Anderson, Susan M., Phillips, Jonathan, Walker, Rosie M., Bermingham, Mairead L., Payne, Abigail L., Giannopoulos, Panagiotis, Pandya, Divya, Spires-Jones, Tara L., Abbott, Catherine M., Porteous, David J., Glerup, Simon, Evans, Kathryn L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Biomedical and Life Sciences Biomedicine Cell Biology Cell Line Cognitive ability Dentate gyrus Deoxyribonucleic acid DNA DNA Breaks, Double-Stranded DNA Damage DNA Repair Humans Mental disorders Mice Nerve Tissue Proteins - metabolism Neurobiology Neurodegeneration Neurons - metabolism Neurosciences Original Research Receptors, Cell Surface - genetics
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