Treatment Strategies and Mechanisms Associated with the Prevention of NASH-Associated HCC by a Toll-like Receptor 4 Inhibitor

We evaluated the cancer preventive efficacy of TAK-242, an inhibitor of Toll-like receptor 4 (TLR4), in a mouse model of hepatocellular carcinoma (HCC) occurring in the context of nonalcoholic steatohepatitis (NASH). We also assessed the cellular events associated with the preventive treatment effic...

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Veröffentlicht in:	Cancer prevention research (Philadelphia, Pa.) Pa.), 2023-01, Vol.16 (1), p.17-28
Hauptverfasser:	Kwan, Suet-Ying, Slayden, Alyssa N, Coronado, Aubrey R, Marquez, Rosamaria C, Chen, Huiqin, Wei, Peng, Savage, Michelle I, Vornik, Lana A, Fox, Jennifer T, Sei, Shizuko, Liang, Dong, Stevenson, Heather L, Wilkerson, Gregory K, Gagea, Mihai, Brown, Powel H, Beretta, Laura
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - prevention & control Endothelial Cells Liver Neoplasms - etiology Liver Neoplasms - prevention & control Mice Non-alcoholic Fatty Liver Disease - complications Non-alcoholic Fatty Liver Disease - drug therapy Toll-Like Receptor 4
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