Structural insights into the regulation of human serine palmitoyltransferase complexes

Sphingolipids are essential lipids in eukaryotic membranes. In humans, the first and rate-limiting step of sphingolipid synthesis is catalyzed by the serine palmitoyltransferase holocomplex, which consists of catalytic components (SPTLC1 and SPTLC2) and regulatory components (ssSPTa and ORMDL3). How...

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Veröffentlicht in:	Nature structural & molecular biology 2021-03, Vol.28 (3), p.240-248
Hauptverfasser:	Wang, Yingdi, Niu, Yiming, Zhang, Zhe, Gable, Kenneth, Gupta, Sita D., Somashekarappa, Niranjanakumari, Han, Gongshe, Zhao, Hongtu, Myasnikov, Alexander G., Kalathur, Ravi C., Dunn, Teresa M., Lee, Chia-Hsueh
Format:	Artikel
Sprache:	eng
Schlagworte:	631/45/287/1192 631/45/607 631/535/1258/1259 Binding Binding Sites Biocatalysis Biochemistry Biological Microscopy Biomedical and Life Sciences Catalytic Domain Chemical synthesis Constraining Cryoelectron Microscopy Electron microscopy Enzymatic activity Enzyme activity Enzymes Humans Life Sciences Ligands Lipids Membrane Biology Membrane Proteins - chemistry Membrane Proteins - genetics Membrane Proteins - metabolism Membrane Proteins - ultrastructure Models, Molecular Mutation Palmitoyltransferase Protein Structure Regulation Regulatory subunits Reproducibility of Results Serine Serine C-Palmitoyltransferase - chemistry Serine C-Palmitoyltransferase - genetics Serine C-Palmitoyltransferase - metabolism Serine C-Palmitoyltransferase - ultrastructure Serine palmitoyltransferase Sphingolipids Substrate Specificity Substrates
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