DLPFC volume is a neural correlate of resilience in healthy high-risk individuals with both childhood maltreatment and familial risk for depression
Two prominent risk factors for major depressive disorder (MDD) are childhood maltreatment (CM) and familial risk for MDD. Despite having these risk factors, there are individuals who maintain mental health, i.e. are resilient, whereas others develop MDD. It is unclear which brain morphological alter...
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| Veröffentlicht in: | Psychological medicine 2022-12, Vol.52 (16), p.4139-4145 |
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| creator | Brosch, Katharina Stein, Frederike Meller, Tina Schmitt, Simon Yuksel, Dilara Ringwald, Kai Gustav Pfarr, Julia-Katharina Waltemate, Lena Lemke, Hannah Opel, Nils Meinert, Susanne Dohm, Katharina Grotegerd, Dominik Goltermann, Janik Repple, Jonathan Winter, Alexandra Jansen, Andreas Dannlowski, Udo Nenadić, Igor Kircher, Tilo Krug, Axel |
| description | Two prominent risk factors for major depressive disorder (MDD) are childhood maltreatment (CM) and familial risk for MDD. Despite having these risk factors, there are individuals who maintain mental health, i.e. are resilient, whereas others develop MDD. It is unclear which brain morphological alterations are associated with this kind of resilience. Interaction analyses of risk and diagnosis status are needed that can account for complex adaptation processes, to identify neural correlates of resilience.
We analyzed brain structural data (3T magnetic resonance imaging) by means of voxel-based morphometry (CAT12 toolbox), using a 2 × 2 design, comparing four groups (N = 804) that differed in diagnosis (healthy v. MDD) and risk profiles (low-risk, i.e. absence of CM and familial risk v. high-risk, i.e. presence of both CM and familial risk). Using regions of interest (ROIs) from the literature, we conducted an interaction analysis of risk and diagnosis status.
Volume in the left middle frontal gyrus (MFG), part of the dorsolateral prefrontal cortex (DLPFC), was significantly higher in healthy high-risk individuals. There were no significant results for the bilateral superior frontal gyri, frontal poles, pars orbitalis of the inferior frontal gyri, and the right MFG.
The healthy high-risk group had significantly higher volumes in the left DLPFC compared to all other groups. The DLPFC is implicated in cognitive and emotional processes, and higher volume in this area might aid high-risk individuals in adaptive coping in order to maintain mental health. This increased volume might therefore constitute a neural correlate of resilience to MDD in high risk. |
| doi_str_mv | 10.1017/S0033291721001094 |
| format | Article |
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We analyzed brain structural data (3T magnetic resonance imaging) by means of voxel-based morphometry (CAT12 toolbox), using a 2 × 2 design, comparing four groups (N = 804) that differed in diagnosis (healthy v. MDD) and risk profiles (low-risk, i.e. absence of CM and familial risk v. high-risk, i.e. presence of both CM and familial risk). Using regions of interest (ROIs) from the literature, we conducted an interaction analysis of risk and diagnosis status.
Volume in the left middle frontal gyrus (MFG), part of the dorsolateral prefrontal cortex (DLPFC), was significantly higher in healthy high-risk individuals. There were no significant results for the bilateral superior frontal gyri, frontal poles, pars orbitalis of the inferior frontal gyri, and the right MFG.
The healthy high-risk group had significantly higher volumes in the left DLPFC compared to all other groups. The DLPFC is implicated in cognitive and emotional processes, and higher volume in this area might aid high-risk individuals in adaptive coping in order to maintain mental health. This increased volume might therefore constitute a neural correlate of resilience to MDD in high risk.</description><identifier>ISSN: 0033-2917</identifier><identifier>EISSN: 1469-8978</identifier><identifier>DOI: 10.1017/S0033291721001094</identifier><identifier>PMID: 33858550</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Brain ; Child abuse & neglect ; Childhood ; Children ; Cognitive ability ; Cohort analysis ; Coping ; Cortex ; Depressive personality disorders ; Diagnosis ; Emotional regulation ; Familial factors ; Frontal gyrus ; High risk ; Interaction analysis ; Investigations ; Magnetic resonance imaging ; Medical diagnosis ; Medical imaging ; Mental depression ; Mental disorders ; Mental health ; Morphometry ; Neuroimaging ; Neurosciences ; Original ; Original Article ; Post traumatic stress disorder ; Prefrontal cortex ; Questionnaires ; Resilience ; Risk factors ; Risk groups</subject><ispartof>Psychological medicine, 2022-12, Vol.52 (16), p.4139-4145</ispartof><rights>Copyright © The Author(s), 2021. Published by Cambridge University Press</rights><rights>Copyright © The Author(s), 2021. Published by Cambridge University Press. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>The Author(s) 2021 2021 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-dc25e8a97440748d7d72bf533f817363b0732450406c795d12f00ba99e8b91503</citedby><cites>FETCH-LOGICAL-c471t-dc25e8a97440748d7d72bf533f817363b0732450406c795d12f00ba99e8b91503</cites><orcidid>0000-0002-0526-8095</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0033291721001094/type/journal_article$$EHTML$$P50$$Gcambridge$$Hfree_for_read</linktohtml><link.rule.ids>164,230,314,776,780,881,12826,27323,27903,27904,30978,33753,55606</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33858550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brosch, Katharina</creatorcontrib><creatorcontrib>Stein, Frederike</creatorcontrib><creatorcontrib>Meller, Tina</creatorcontrib><creatorcontrib>Schmitt, Simon</creatorcontrib><creatorcontrib>Yuksel, Dilara</creatorcontrib><creatorcontrib>Ringwald, Kai Gustav</creatorcontrib><creatorcontrib>Pfarr, Julia-Katharina</creatorcontrib><creatorcontrib>Waltemate, Lena</creatorcontrib><creatorcontrib>Lemke, Hannah</creatorcontrib><creatorcontrib>Opel, Nils</creatorcontrib><creatorcontrib>Meinert, Susanne</creatorcontrib><creatorcontrib>Dohm, Katharina</creatorcontrib><creatorcontrib>Grotegerd, Dominik</creatorcontrib><creatorcontrib>Goltermann, Janik</creatorcontrib><creatorcontrib>Repple, Jonathan</creatorcontrib><creatorcontrib>Winter, Alexandra</creatorcontrib><creatorcontrib>Jansen, Andreas</creatorcontrib><creatorcontrib>Dannlowski, Udo</creatorcontrib><creatorcontrib>Nenadić, Igor</creatorcontrib><creatorcontrib>Kircher, Tilo</creatorcontrib><creatorcontrib>Krug, Axel</creatorcontrib><title>DLPFC volume is a neural correlate of resilience in healthy high-risk individuals with both childhood maltreatment and familial risk for depression</title><title>Psychological medicine</title><addtitle>Psychol. Med</addtitle><description>Two prominent risk factors for major depressive disorder (MDD) are childhood maltreatment (CM) and familial risk for MDD. Despite having these risk factors, there are individuals who maintain mental health, i.e. are resilient, whereas others develop MDD. It is unclear which brain morphological alterations are associated with this kind of resilience. Interaction analyses of risk and diagnosis status are needed that can account for complex adaptation processes, to identify neural correlates of resilience.
We analyzed brain structural data (3T magnetic resonance imaging) by means of voxel-based morphometry (CAT12 toolbox), using a 2 × 2 design, comparing four groups (N = 804) that differed in diagnosis (healthy v. MDD) and risk profiles (low-risk, i.e. absence of CM and familial risk v. high-risk, i.e. presence of both CM and familial risk). Using regions of interest (ROIs) from the literature, we conducted an interaction analysis of risk and diagnosis status.
Volume in the left middle frontal gyrus (MFG), part of the dorsolateral prefrontal cortex (DLPFC), was significantly higher in healthy high-risk individuals. There were no significant results for the bilateral superior frontal gyri, frontal poles, pars orbitalis of the inferior frontal gyri, and the right MFG.
The healthy high-risk group had significantly higher volumes in the left DLPFC compared to all other groups. The DLPFC is implicated in cognitive and emotional processes, and higher volume in this area might aid high-risk individuals in adaptive coping in order to maintain mental health. This increased volume might therefore constitute a neural correlate of resilience to MDD in high risk.</description><subject>Brain</subject><subject>Child abuse & neglect</subject><subject>Childhood</subject><subject>Children</subject><subject>Cognitive ability</subject><subject>Cohort analysis</subject><subject>Coping</subject><subject>Cortex</subject><subject>Depressive personality disorders</subject><subject>Diagnosis</subject><subject>Emotional regulation</subject><subject>Familial factors</subject><subject>Frontal gyrus</subject><subject>High risk</subject><subject>Interaction analysis</subject><subject>Investigations</subject><subject>Magnetic resonance imaging</subject><subject>Medical diagnosis</subject><subject>Medical imaging</subject><subject>Mental depression</subject><subject>Mental disorders</subject><subject>Mental health</subject><subject>Morphometry</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Original</subject><subject>Original Article</subject><subject>Post traumatic stress disorder</subject><subject>Prefrontal cortex</subject><subject>Questionnaires</subject><subject>Resilience</subject><subject>Risk factors</subject><subject>Risk 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volume is a neural correlate of resilience in healthy high-risk individuals with both childhood maltreatment and familial risk for depression</title><author>Brosch, Katharina ; Stein, Frederike ; Meller, Tina ; Schmitt, Simon ; Yuksel, Dilara ; Ringwald, Kai Gustav ; Pfarr, Julia-Katharina ; Waltemate, Lena ; Lemke, Hannah ; Opel, Nils ; Meinert, Susanne ; Dohm, Katharina ; Grotegerd, Dominik ; Goltermann, Janik ; Repple, Jonathan ; Winter, Alexandra ; Jansen, Andreas ; Dannlowski, Udo ; Nenadić, Igor ; Kircher, Tilo ; Krug, Axel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-dc25e8a97440748d7d72bf533f817363b0732450406c795d12f00ba99e8b91503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Brain</topic><topic>Child abuse & neglect</topic><topic>Childhood</topic><topic>Children</topic><topic>Cognitive ability</topic><topic>Cohort 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Frederike</au><au>Meller, Tina</au><au>Schmitt, Simon</au><au>Yuksel, Dilara</au><au>Ringwald, Kai Gustav</au><au>Pfarr, Julia-Katharina</au><au>Waltemate, Lena</au><au>Lemke, Hannah</au><au>Opel, Nils</au><au>Meinert, Susanne</au><au>Dohm, Katharina</au><au>Grotegerd, Dominik</au><au>Goltermann, Janik</au><au>Repple, Jonathan</au><au>Winter, Alexandra</au><au>Jansen, Andreas</au><au>Dannlowski, Udo</au><au>Nenadić, Igor</au><au>Kircher, Tilo</au><au>Krug, Axel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DLPFC volume is a neural correlate of resilience in healthy high-risk individuals with both childhood maltreatment and familial risk for depression</atitle><jtitle>Psychological medicine</jtitle><addtitle>Psychol. Med</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>52</volume><issue>16</issue><spage>4139</spage><epage>4145</epage><pages>4139-4145</pages><issn>0033-2917</issn><eissn>1469-8978</eissn><abstract>Two prominent risk factors for major depressive disorder (MDD) are childhood maltreatment (CM) and familial risk for MDD. Despite having these risk factors, there are individuals who maintain mental health, i.e. are resilient, whereas others develop MDD. It is unclear which brain morphological alterations are associated with this kind of resilience. Interaction analyses of risk and diagnosis status are needed that can account for complex adaptation processes, to identify neural correlates of resilience.
We analyzed brain structural data (3T magnetic resonance imaging) by means of voxel-based morphometry (CAT12 toolbox), using a 2 × 2 design, comparing four groups (N = 804) that differed in diagnosis (healthy v. MDD) and risk profiles (low-risk, i.e. absence of CM and familial risk v. high-risk, i.e. presence of both CM and familial risk). Using regions of interest (ROIs) from the literature, we conducted an interaction analysis of risk and diagnosis status.
Volume in the left middle frontal gyrus (MFG), part of the dorsolateral prefrontal cortex (DLPFC), was significantly higher in healthy high-risk individuals. There were no significant results for the bilateral superior frontal gyri, frontal poles, pars orbitalis of the inferior frontal gyri, and the right MFG.
The healthy high-risk group had significantly higher volumes in the left DLPFC compared to all other groups. The DLPFC is implicated in cognitive and emotional processes, and higher volume in this area might aid high-risk individuals in adaptive coping in order to maintain mental health. This increased volume might therefore constitute a neural correlate of resilience to MDD in high risk.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>33858550</pmid><doi>10.1017/S0033291721001094</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0526-8095</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Psychological medicine, 2022-12, Vol.52 (16), p.4139-4145 |
| issn | 0033-2917 1469-8978 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9811272 |
| source | Sociological Abstracts; Applied Social Sciences Index & Abstracts (ASSIA); Cambridge University Press Journals Complete |
| subjects | Brain Child abuse & neglect Childhood Children Cognitive ability Cohort analysis Coping Cortex Depressive personality disorders Diagnosis Emotional regulation Familial factors Frontal gyrus High risk Interaction analysis Investigations Magnetic resonance imaging Medical diagnosis Medical imaging Mental depression Mental disorders Mental health Morphometry Neuroimaging Neurosciences Original Original Article Post traumatic stress disorder Prefrontal cortex Questionnaires Resilience Risk factors Risk groups |
| title | DLPFC volume is a neural correlate of resilience in healthy high-risk individuals with both childhood maltreatment and familial risk for depression |
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