Identification, binding, and structural characterization of single domain anti-PD-L1 antibodies inhibitory of immune regulatory proteins PD-1 and CD80

Programmed death-ligand 1 (PD-L1) is a key immune regulatory protein that interacts with programmed cell death protein 1 (PD-1), leading to T-cell suppression. Whilst this interaction is key in self-tolerance, cancer cells evade the immune system by overexpressing PD-L1. Inhibition of the PD-1/PD-L1...

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Veröffentlicht in:	The Journal of biological chemistry 2023-01, Vol.299 (1), p.102769-102769, Article 102769
Hauptverfasser:	Kang-Pettinger, Tara, Walker, Kayleigh, Brown, Richard, Cowan, Richard, Wright, Helena, Baravalle, Roberta, Waters, Lorna C., Muskett, Frederick W., Bowler, Matthew W., Sawmynaden, Kovilen, Coombs, Peter J., Carr, Mark D., Hall, Gareth
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - chemistry Antibodies - metabolism B7-1 Antigen - metabolism B7-H1 Antigen - genetics B7-H1 Antigen - metabolism Binding Sites cancer Cluster of differentiation 80 Crystallography Humans immunoglobulin-like domain immunotherapy Neoplasms - therapy phage display Programmed Cell Death 1 Receptor - metabolism programmed cell death protein 1 programmed death-ligand 1 Protein Binding single-domain antibody (sdAb, nanobody)
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