ETV3 and ETV6 enable monocyte differentiation into dendritic cells by repressing macrophage fate commitment

In inflamed tissues, monocytes differentiate into macrophages (mo-Macs) or dendritic cells (mo-DCs). In chronic nonresolving inflammation, mo-DCs are major drivers of pathogenic events. Manipulating monocyte differentiation would therefore be an attractive therapeutic strategy. However, how the bala...

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Veröffentlicht in:Nature immunology 2023-01, Vol.24 (1), p.84-95
Hauptverfasser: Villar, Javiera, Cros, Adeline, De Juan, Alba, Alaoui, Lamine, Bonte, Pierre-Emmanuel, Lau, Colleen M., Tiniakou, Ioanna, Reizis, Boris, Segura, Elodie
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Sprache:eng
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