HMGA2 drives the IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA/RNA‐less cancer cells

Recent comprehensive analyses of mtDNA and orthogonal RNA‐sequencing data revealed that in numerous human cancers, mtDNA copy numbers and mtRNA amounts are significantly reduced, followed by low respiratory gene expression. Under such conditions (called mt‐Low), cells encounter severe cell prolifera...

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Veröffentlicht in:	Cancer science 2023-01, Vol.114 (1), p.152-163
Hauptverfasser:	Maruyama, Tsuyoshi, Saito, Koji, Higurashi, Masato, Ishikawa, Fumihiro, Kohno, Yohko, Mori, Kazunori, Shibanuma, Motoko
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT protein Analysis Cancer Cancer cells Carcinoma, Hepatocellular - pathology Cell cycle Cell growth Cell Line, Tumor Cell proliferation Cell Proliferation - genetics Chromosomal proteins Cyclin-dependent kinase inhibitor p27 Cyclin-Dependent Kinase Inhibitor p27 - genetics Cyclin-Dependent Kinase Inhibitor p27 - metabolism Cyclin-dependent kinases DNA, Mitochondrial Gene expression Gene Expression Regulation, Neoplastic Hepatocellular carcinoma HMGA2 Humans IGFBP1 Insulin Insulin-Like Growth Factor Binding Protein 1 Insulin-like growth factors Kinases Liver cancer Liver Neoplasms - pathology mitochondria deficiency Mitochondrial DNA Original ORIGINAL ARTICLES P27KIP1 Protein binding Protein Kinase Inhibitors - pharmacology Proteins Proto-Oncogene Proteins c-akt - metabolism RNA RNA sequencing RNA-mediated interference Senescence Ubiquitin
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