Pregnancy After Breast Cancer - Prognostic Safety and Pregnancy Outcomes According to Oestrogen Receptor Status: A Systematic Review

Breast cancer is the primary cause of cancer-related death in women. Women diagnosed with estrogen receptor (ER)-positive breast cancer have prolonged treatment durations. Owing to the paucity of research and lack of consensus regarding conception planning and pregnancy for patients with ER-positive...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of breast cancer 2022-12, Vol.25 (6), p.443-453
Hauptverfasser: Nolan, Katie, Boland, Michael R, Hill, Arnold D K
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 453
container_issue 6
container_start_page 443
container_title Journal of breast cancer
container_volume 25
creator Nolan, Katie
Boland, Michael R
Hill, Arnold D K
description Breast cancer is the primary cause of cancer-related death in women. Women diagnosed with estrogen receptor (ER)-positive breast cancer have prolonged treatment durations. Owing to the paucity of research and lack of consensus regarding conception planning and pregnancy for patients with ER-positive breast cancer, we aimed to assess pregnancy and survival outcomes in women with ER-positive breast cancer during and after treatment. We conducted a systematic review of the available studies on pregnancy after ER-positive breast cancer. The assessed outcomes included overall survival (OS), disease-free survival (DFS), hormonal therapy duration, and pregnancy outcomes. Ultimately, 2,669 patients from five studies were included in this study. When all breast cancer receptor subtypes were included in the analysis, pregnancy after breast cancer was associated with a time-dependent protective effect on both DFS and OS. This protective effect was not evident when examining ER-positive patients with subsequent pregnancies, and no significant differences in DFS were observed. ER-positive patients who became pregnant received significantly lower rates of hormonal therapy. Hormonal treatment at the time of pregnancy was correlated with increased rates of termination owing to concerns about teratogenic effects. Pregnancy after breast cancer did not significantly affect DFS in ER-positive patients over a follow-up period of 5-10 years from diagnosis, although did significantly affect hormonal treatment duration in the reviewed studies. Further analysis and in-depth studies are required to assess the effects of altered hormonal treatment times, as well as patient management related to pregnancy planning after breast cancer.
doi_str_mv 10.4048/jbc.2022.25.e45
format Article
fullrecord <record><control><sourceid>pubmed_cross</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9807324</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>36479601</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-52ba99d2cdb411e0b2375df65cef8afb3d7ac3b324fffa465f7ffc9e8dfea3dc3</originalsourceid><addsrcrecordid>eNpVkclOwzAQhi0EgrKcuSG_QIpjO3HCAalUbFKlIgpny7HHIRWJK9styp0HJxX7aTTL_83hQ-g0JWNOeHG-rPSYEkrHNBsDz3bQiJKSJmVJyC4apYIVSS6y_AAdhrAkJOdMiH10wHIuypykI_T-4KHuVKd7PLERPL7yoELE02E0dAl-8K7uXIiNxgtlIfZYdQb_pubrqF0LAU-0dt40XY2jw3MIcQhChx9Bwyo6jxdRxXW4wBO86EOEVm2Rj7Bp4O0Y7Vn1GuDkqx6h55vrp-ldMpvf3k8ns0QzLmKS0UqVpaHaVDxNgVSUiczYPNNgC2UrZoTSrGKUW2sVzzMrrNUlFMaCYkazI3T5yV2tqxaMhi569SpXvmmV76VTjfy_6ZoXWbuNLAsiBuwAOP8EaO9C8GB_simRWyFyECK3QiTN5CBkSJz9fflz_22AfQAawIzE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Pregnancy After Breast Cancer - Prognostic Safety and Pregnancy Outcomes According to Oestrogen Receptor Status: A Systematic Review</title><source>KoreaMed Synapse</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>KoreaMed Open Access</source><source>PubMed Central</source><creator>Nolan, Katie ; Boland, Michael R ; Hill, Arnold D K</creator><creatorcontrib>Nolan, Katie ; Boland, Michael R ; Hill, Arnold D K</creatorcontrib><description>Breast cancer is the primary cause of cancer-related death in women. Women diagnosed with estrogen receptor (ER)-positive breast cancer have prolonged treatment durations. Owing to the paucity of research and lack of consensus regarding conception planning and pregnancy for patients with ER-positive breast cancer, we aimed to assess pregnancy and survival outcomes in women with ER-positive breast cancer during and after treatment. We conducted a systematic review of the available studies on pregnancy after ER-positive breast cancer. The assessed outcomes included overall survival (OS), disease-free survival (DFS), hormonal therapy duration, and pregnancy outcomes. Ultimately, 2,669 patients from five studies were included in this study. When all breast cancer receptor subtypes were included in the analysis, pregnancy after breast cancer was associated with a time-dependent protective effect on both DFS and OS. This protective effect was not evident when examining ER-positive patients with subsequent pregnancies, and no significant differences in DFS were observed. ER-positive patients who became pregnant received significantly lower rates of hormonal therapy. Hormonal treatment at the time of pregnancy was correlated with increased rates of termination owing to concerns about teratogenic effects. Pregnancy after breast cancer did not significantly affect DFS in ER-positive patients over a follow-up period of 5-10 years from diagnosis, although did significantly affect hormonal treatment duration in the reviewed studies. Further analysis and in-depth studies are required to assess the effects of altered hormonal treatment times, as well as patient management related to pregnancy planning after breast cancer.</description><identifier>ISSN: 1738-6756</identifier><identifier>EISSN: 2092-9900</identifier><identifier>DOI: 10.4048/jbc.2022.25.e45</identifier><identifier>PMID: 36479601</identifier><language>eng</language><publisher>Korea (South): Korean Breast Cancer Society</publisher><subject>Original</subject><ispartof>Journal of breast cancer, 2022-12, Vol.25 (6), p.443-453</ispartof><rights>2022 Korean Breast Cancer Society.</rights><rights>2022 Korean Breast Cancer Society 2022 Korean Breast Cancer Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c347t-52ba99d2cdb411e0b2375df65cef8afb3d7ac3b324fffa465f7ffc9e8dfea3dc3</cites><orcidid>0000-0002-6724-5630 ; 0000-0003-4650-4776 ; 0000-0001-9617-7983</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807324/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9807324/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,27933,27934,53800,53802</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36479601$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nolan, Katie</creatorcontrib><creatorcontrib>Boland, Michael R</creatorcontrib><creatorcontrib>Hill, Arnold D K</creatorcontrib><title>Pregnancy After Breast Cancer - Prognostic Safety and Pregnancy Outcomes According to Oestrogen Receptor Status: A Systematic Review</title><title>Journal of breast cancer</title><addtitle>J Breast Cancer</addtitle><description>Breast cancer is the primary cause of cancer-related death in women. Women diagnosed with estrogen receptor (ER)-positive breast cancer have prolonged treatment durations. Owing to the paucity of research and lack of consensus regarding conception planning and pregnancy for patients with ER-positive breast cancer, we aimed to assess pregnancy and survival outcomes in women with ER-positive breast cancer during and after treatment. We conducted a systematic review of the available studies on pregnancy after ER-positive breast cancer. The assessed outcomes included overall survival (OS), disease-free survival (DFS), hormonal therapy duration, and pregnancy outcomes. Ultimately, 2,669 patients from five studies were included in this study. When all breast cancer receptor subtypes were included in the analysis, pregnancy after breast cancer was associated with a time-dependent protective effect on both DFS and OS. This protective effect was not evident when examining ER-positive patients with subsequent pregnancies, and no significant differences in DFS were observed. ER-positive patients who became pregnant received significantly lower rates of hormonal therapy. Hormonal treatment at the time of pregnancy was correlated with increased rates of termination owing to concerns about teratogenic effects. Pregnancy after breast cancer did not significantly affect DFS in ER-positive patients over a follow-up period of 5-10 years from diagnosis, although did significantly affect hormonal treatment duration in the reviewed studies. Further analysis and in-depth studies are required to assess the effects of altered hormonal treatment times, as well as patient management related to pregnancy planning after breast cancer.</description><subject>Original</subject><issn>1738-6756</issn><issn>2092-9900</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpVkclOwzAQhi0EgrKcuSG_QIpjO3HCAalUbFKlIgpny7HHIRWJK9styp0HJxX7aTTL_83hQ-g0JWNOeHG-rPSYEkrHNBsDz3bQiJKSJmVJyC4apYIVSS6y_AAdhrAkJOdMiH10wHIuypykI_T-4KHuVKd7PLERPL7yoELE02E0dAl-8K7uXIiNxgtlIfZYdQb_pubrqF0LAU-0dt40XY2jw3MIcQhChx9Bwyo6jxdRxXW4wBO86EOEVm2Rj7Bp4O0Y7Vn1GuDkqx6h55vrp-ldMpvf3k8ns0QzLmKS0UqVpaHaVDxNgVSUiczYPNNgC2UrZoTSrGKUW2sVzzMrrNUlFMaCYkazI3T5yV2tqxaMhi569SpXvmmV76VTjfy_6ZoXWbuNLAsiBuwAOP8EaO9C8GB_simRWyFyECK3QiTN5CBkSJz9fflz_22AfQAawIzE</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Nolan, Katie</creator><creator>Boland, Michael R</creator><creator>Hill, Arnold D K</creator><general>Korean Breast Cancer Society</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6724-5630</orcidid><orcidid>https://orcid.org/0000-0003-4650-4776</orcidid><orcidid>https://orcid.org/0000-0001-9617-7983</orcidid></search><sort><creationdate>20221201</creationdate><title>Pregnancy After Breast Cancer - Prognostic Safety and Pregnancy Outcomes According to Oestrogen Receptor Status: A Systematic Review</title><author>Nolan, Katie ; Boland, Michael R ; Hill, Arnold D K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-52ba99d2cdb411e0b2375df65cef8afb3d7ac3b324fffa465f7ffc9e8dfea3dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Original</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nolan, Katie</creatorcontrib><creatorcontrib>Boland, Michael R</creatorcontrib><creatorcontrib>Hill, Arnold D K</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of breast cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nolan, Katie</au><au>Boland, Michael R</au><au>Hill, Arnold D K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pregnancy After Breast Cancer - Prognostic Safety and Pregnancy Outcomes According to Oestrogen Receptor Status: A Systematic Review</atitle><jtitle>Journal of breast cancer</jtitle><addtitle>J Breast Cancer</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>25</volume><issue>6</issue><spage>443</spage><epage>453</epage><pages>443-453</pages><issn>1738-6756</issn><eissn>2092-9900</eissn><abstract>Breast cancer is the primary cause of cancer-related death in women. Women diagnosed with estrogen receptor (ER)-positive breast cancer have prolonged treatment durations. Owing to the paucity of research and lack of consensus regarding conception planning and pregnancy for patients with ER-positive breast cancer, we aimed to assess pregnancy and survival outcomes in women with ER-positive breast cancer during and after treatment. We conducted a systematic review of the available studies on pregnancy after ER-positive breast cancer. The assessed outcomes included overall survival (OS), disease-free survival (DFS), hormonal therapy duration, and pregnancy outcomes. Ultimately, 2,669 patients from five studies were included in this study. When all breast cancer receptor subtypes were included in the analysis, pregnancy after breast cancer was associated with a time-dependent protective effect on both DFS and OS. This protective effect was not evident when examining ER-positive patients with subsequent pregnancies, and no significant differences in DFS were observed. ER-positive patients who became pregnant received significantly lower rates of hormonal therapy. Hormonal treatment at the time of pregnancy was correlated with increased rates of termination owing to concerns about teratogenic effects. Pregnancy after breast cancer did not significantly affect DFS in ER-positive patients over a follow-up period of 5-10 years from diagnosis, although did significantly affect hormonal treatment duration in the reviewed studies. Further analysis and in-depth studies are required to assess the effects of altered hormonal treatment times, as well as patient management related to pregnancy planning after breast cancer.</abstract><cop>Korea (South)</cop><pub>Korean Breast Cancer Society</pub><pmid>36479601</pmid><doi>10.4048/jbc.2022.25.e45</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-6724-5630</orcidid><orcidid>https://orcid.org/0000-0003-4650-4776</orcidid><orcidid>https://orcid.org/0000-0001-9617-7983</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1738-6756
ispartof Journal of breast cancer, 2022-12, Vol.25 (6), p.443-453
issn 1738-6756
2092-9900
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9807324
source KoreaMed Synapse; DOAJ Directory of Open Access Journals; PubMed Central Open Access; KoreaMed Open Access; PubMed Central
subjects Original
title Pregnancy After Breast Cancer - Prognostic Safety and Pregnancy Outcomes According to Oestrogen Receptor Status: A Systematic Review
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T12%3A34%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pregnancy%20After%20Breast%20Cancer%20-%20Prognostic%20Safety%20and%20Pregnancy%20Outcomes%20According%20to%20Oestrogen%20Receptor%20Status:%20A%20Systematic%20Review&rft.jtitle=Journal%20of%20breast%20cancer&rft.au=Nolan,%20Katie&rft.date=2022-12-01&rft.volume=25&rft.issue=6&rft.spage=443&rft.epage=453&rft.pages=443-453&rft.issn=1738-6756&rft.eissn=2092-9900&rft_id=info:doi/10.4048/jbc.2022.25.e45&rft_dat=%3Cpubmed_cross%3E36479601%3C/pubmed_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/36479601&rfr_iscdi=true