The NO/cGMP/PKG pathway in platelets: The therapeutic potential of PDE5 inhibitors in platelet disorders

Platelets are the “guardians” of the blood circulatory system. At sites of vessel injury, they ensure hemostasis and promote immunity and vessel repair. However, their uncontrolled activation is one of the main drivers of thrombosis. To keep circulating platelets in a quiescent state, the endotheliu...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2022-11, Vol.20 (11), p.2465-2474
Hauptverfasser:	Degjoni, Anisa, Campolo, Federica, Stefanini, Lucia, Venneri, Mary Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Antagonists Antiplatelet therapy Blood platelets Blood Platelets - metabolism Circulatory system Congestive heart failure Cyclic GMP Cyclic GMP - metabolism Cyclic GMP-Dependent Protein Kinases - metabolism cyclic guanosine‐3′,5′‐monophosphate Cyclic Nucleotide Phosphodiesterases, Type 5 - metabolism Cyclic Nucleotide Phosphodiesterases, Type 5 - pharmacology Cyclic nucleotides Drug delivery Endothelium Erectile dysfunction Guanosine - metabolism Guanosine - pharmacology Guanylate cyclase Guanylate Cyclase - metabolism Guanylate Cyclase - pharmacology Hemostasis Humans Intracellular Kinases Male Molecular modelling Nitric oxide Nitric Oxide - metabolism nitric oxide donors Nitric Oxide Donors - metabolism Nucleotides Nucleotides, Cyclic - metabolism Nucleotides, Cyclic - pharmacology Phosphodiesterase Phosphodiesterase 5 Inhibitors - metabolism Phosphodiesterase 5 Inhibitors - pharmacology Phosphodiesterase 5 Inhibitors - therapeutic use phosphodiesterase type 5 phosphodiesterase type 5 inhibitors Platelet aggregation Platelet Aggregation Inhibitors - pharmacology Platelet Aggregation Inhibitors - therapeutic use platelet disorders Protein kinase G Protein Kinases - metabolism Pulmonary arteries Pulmonary artery Review Thrombosis Urinary tract
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