Oxalate Oxidase for In Situ H2O2‐Generation in Unspecific Peroxygenase‐Catalysed Drug Oxyfunctionalisations

H2O2‐driven enzymes are of great interest for industrial biotransformations. Herein, we show for the first time that oxalate oxidase (OXO) is an efficient in situ source of H2O2 for one of these biocatalysts, which is known as unspecific peroxygenase (UPO). OXO is reasonably robust, produces only CO...

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Veröffentlicht in:	Angewandte Chemie International Edition 2022-09, Vol.61 (39), p.n/a
Hauptverfasser:	Romero, Elvira, Johansson, Magnus J., Cartwright, Jared, Grogan, Gideon, Hayes, Martin A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biocatalysis Biocatalysts Biotransformation Carbon dioxide Catalysts Communication Communications Drug Late-Stage Functionalisation Drugs H2O2-Generation High-Throughput Screening Hydrogen peroxide Immobilization Mass spectrometry Mass spectroscopy Oxalate oxidase Oxalic acid Oxidase Oxidation Oxidoreductases Tolmetin
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