Microglial angiotensin type 2 receptors mediate sex‐specific expression of inflammatory cytokines independently of circulating estrogen

There are sex differences in microglia, which can maintain sex‐related gene expression and functional differences in the absence of circulating sex steroids. The angiotensin type 2 (AT2) receptors mediate anti‐inflammatory actions in different tissues, including brain. In mice, we performed RT‐PCR a...

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Veröffentlicht in:	Glia 2022-12, Vol.70 (12), p.2348-2360
Hauptverfasser:	Garrido‐Gil, Pablo, Pedrosa, Maria A., Garcia‐Garrote, Maria, Pequeño‐Valtierra, Ana, Rodríguez‐Castro, Jorge, García‐Souto, Daniel, Rodríguez‐Pérez, Ana I., Labandeira‐Garcia, Jose L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin AT2 receptors Angiotensins - metabolism Angiotensins - pharmacology Animals Anti-Inflammatory Agents - pharmacology AT2 receptor Brain Chromosomes Cytokines Cytokines - metabolism Estrogens Estrogens - metabolism Estrogens - pharmacology Female Females gender Gender differences Gene expression gonadal hormones Hormones Hybridization Inflammation Interleukin 6 Interleukin-10 - metabolism Interleukin-1beta - metabolism Interleukin-6 - metabolism interleukins Male Males Mice Microglia Microglia - metabolism Microglial cells neuroinflammation Ovariectomy Receptor, Angiotensin, Type 2 - genetics Receptor, Angiotensin, Type 2 - metabolism Receptors RNA - metabolism RNA, Messenger - metabolism sex chromosome complement Sex chromosomes Sex differences sex dimorphism Steroid hormones Steroids
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