Pentoxifylline as a therapeutic option for pre‐eclampsia: a study on its placental effects

Background and Purpose Recently pentoxifylline, a non‐selective phosphodiesterase inhibitor and adenosine receptor antagonist, has attracted much interest for the treatment of the increased vascular resistance and endothelial dysfunction in pre‐eclampsia. We therefore investigated the placental tran...

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Veröffentlicht in:	British journal of pharmacology 2022-11, Vol.179 (22), p.5074-5088
Hauptverfasser:	Broekhuizen, Michelle, Vries, Rene, Smits, Marja A. W., Dik, Willem A., Schoenmakers, Sam, Koch, Birgit C. P., Merkus, Daphne, Reiss, Irwin K. M., Danser, A. H. Jan, Simons, Sinno H. P., Hitzerd, Emilie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine - pharmacology Anti-Inflammatory Agents - pharmacology Arteries Cyclic AMP Cyclic GMP Cyclic GMP - metabolism Eclampsia Explants Female Humans Inflammation nitric oxide Nitric Oxide Synthase - metabolism Nitric-oxide synthase pentoxifylline Pentoxifylline - metabolism Pentoxifylline - pharmacology Pentoxifylline - therapeutic use Phosphodiesterase Phosphodiesterase inhibitors Phosphodiesterase Inhibitors - pharmacology Phosphodiesterase Inhibitors - therapeutic use Placenta Placenta - metabolism Placental transfer Pre-Eclampsia - drug therapy Preeclampsia Pregnancy pre‐eclampsia Purinergic P1 Receptor Antagonists - metabolism Purinergic P1 Receptor Antagonists - pharmacology Purinergic P1 Receptor Antagonists - therapeutic use Signal transduction Vasodilation Vasodilator Agents - pharmacology Vasodilators
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