Membrane Manipulation of Giant Unilamellar Polymer Vesicles with a Temperature‐Responsive Polymer
Understanding the complex behavior and dynamics of cellular membranes is integral to gain insight into cellular division and fusion processes. Bottom‐up synthetic cells are as a platform for replicating and probing cellular behavior. Giant polymer vesicles are more robust than liposomal counterparts...
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| Veröffentlicht in: | Angewandte Chemie International Edition 2022-09, Vol.61 (39), p.e202207998-n/a |
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| creator | Souza Melchiors, Marina Ivanov, Tsvetomir Harley, Iain Sayer, Claudia Araújo, Pedro H. H. Caire da Silva, Lucas Ferguson, Calum T. J. Landfester, Katharina |
| description | Understanding the complex behavior and dynamics of cellular membranes is integral to gain insight into cellular division and fusion processes. Bottom‐up synthetic cells are as a platform for replicating and probing cellular behavior. Giant polymer vesicles are more robust than liposomal counterparts, as well as having a broad range of chemical functionalities. However, the stability of the membrane can prohibit dynamic processes such as membrane phase separation and division. Here, we present a method for manipulating the membrane of giant polymersomes using a temperature responsive polymer. Upon elevation of temperature deformation and phase separation of the membrane was observed. Upon cooling, the membrane relaxed and became homogeneous again, with infrequent division of the synthetic cells.
Membrane manipulation of giant polymers using a temperature‐responsive polymer is reported. The strategy makes it possible to develop materials and create compartmentalized systems that can mimic the adaptive properties of biomembranes. |
| doi_str_mv | 10.1002/anie.202207998 |
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Membrane manipulation of giant polymers using a temperature‐responsive polymer is reported. The strategy makes it possible to develop materials and create compartmentalized systems that can mimic the adaptive properties of biomembranes.</description><subject>Artificial Cells</subject><subject>Biomimetic Membranes</subject><subject>Block Copolymers</subject><subject>Cell membranes</subject><subject>Communication</subject><subject>Communications</subject><subject>Dynamic stability</subject><subject>Membrane Manipulation</subject><subject>Membranes</subject><subject>Phase Separation</subject><subject>Phase Transition</subject><subject>Polymers</subject><subject>Polymersomes</subject><subject>Temperature</subject><subject>Unilamellar Liposomes</subject><subject>Vesicles</subject><issn>1433-7851</issn><issn>1521-3773</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNqFkU1PFTEUhhujAUS2Ls0kbtjca7-m025MCEEkASUE3Dadzhkp6bRjOwO5O3-Cv9FfYm8uXD82btomfc6T8-ZF6DXBS4IxfWeCgyXFlOJGKfkM7ZGakgVrGva8vDlji0bWZBe9zPmu8FJisYN2Wa2oEljtIXsBQ5tMgOqiqMbZm8nFUMW-OnUmTNVNcN4M4L1J1WX0qwFS9QWysx5y9eCm28pU1zCMkMw0J_j5_ccV5DGG7O7haeAVetEbn-Hg8d5HNx9Oro8_Ls4_n54dH50vLBdSlpMyWvO6kUzavjEda6XqmAViJCeitx3vDTWkE6CsaHvFQfCubzuhoGWmZvvo_cY7zu0AnYUwJeP1mNxg0kpH4_TfP8Hd6q_xXiuJOW9UERw-ClL8NkOe9OCyXYcPEOesqVCqwZJTUdC3_6B3cU6hxNO0ITWnVFBaqOWGsinmnKDfLkOwXven1_3pbX9l4M2fEbb4U2EFUBvgwXlY_Uenjz6dnfyW_wIMHqtL</recordid><startdate>20220926</startdate><enddate>20220926</enddate><creator>Souza Melchiors, Marina</creator><creator>Ivanov, Tsvetomir</creator><creator>Harley, Iain</creator><creator>Sayer, Claudia</creator><creator>Araújo, Pedro H. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Artificial Cells Biomimetic Membranes Block Copolymers Cell membranes Communication Communications Dynamic stability Membrane Manipulation Membranes Phase Separation Phase Transition Polymers Polymersomes Temperature Unilamellar Liposomes Vesicles |
| title | Membrane Manipulation of Giant Unilamellar Polymer Vesicles with a Temperature‐Responsive Polymer |
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