The long‐term evolution of melanocytic nevi among high‐risk adults
Background There is little understanding regarding the long‐term natural history of melanocytic nevi among adults. Objective The objective of the study was to describe the long‐term natural history of individual nevi located on the torso of high‐risk patients. Methods All patients attending Memorial...
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| Veröffentlicht in: | Journal of the European Academy of Dermatology and Venereology 2022-12, Vol.36 (12), p.2379-2387 |
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| creator | Reiter, O. Kurtansky, N.R. Musthaq, S.T. Dusza, S. Halpern, A.C. Marchetti, M.A. Marghoob, A.A. Scope, A. Rotemberg, V. |
| description | Background
There is little understanding regarding the long‐term natural history of melanocytic nevi among adults.
Objective
The objective of the study was to describe the long‐term natural history of individual nevi located on the torso of high‐risk patients.
Methods
All patients attending Memorial Sloan Kettering Cancer Center (MSKCC) who underwent two total body photography (TBP) sessions 15+ years apart were included (‘retrospective’ group). To account for a potential selection bias, we also included consecutive patients who had TBP 15+ years ago and consented to undergo follow‐up TBP (‘prospective’ group). We compared baseline and follow‐up torso images on the TBPs and evaluated the number of total, new and disappearing nevi; number of seborrheic keratoses and actinic keratoses; each nevus' diameter at both time points; each nevus' colour change; the presence of clinical atypia; and when dermoscopy was available, the dermoscopic features at each time point.
Results
One hundred six patients were included in the study. Although the average age of the patients was 40 at baseline TBP, most patients developed new nevi between imaging sessions (median 16.4 years) with an average of 2.6 (SD = 4.8) nevi per participant. The average number of disappearing nevi was 0.3 (SD = 0.6). In addition, 62/106 (58%) patients had an absolute increase, and 9/106 (8%) patients had an absolute decrease in their total nevus count. Roughly half (49%: 1416/2890) of the nevi that could be evaluated at both time points increased in diameter by at least 25%. Only 6% (159/2890) of nevi shrunk in diameter by at least 25%. Patients with a history of melanoma had a higher rate of disappearing nevi, and their nevi were more likely to grow. Most nevi demonstrated no significant dermoscopic changes.
Conclusions
High‐risk patients acquire new nevi throughout life with very few nevi disappearing over time. Contrary to prior reports, most nevi in adults increase in diameter, while few nevi shrink. |
| doi_str_mv | 10.1111/jdv.18470 |
| format | Article |
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There is little understanding regarding the long‐term natural history of melanocytic nevi among adults.
Objective
The objective of the study was to describe the long‐term natural history of individual nevi located on the torso of high‐risk patients.
Methods
All patients attending Memorial Sloan Kettering Cancer Center (MSKCC) who underwent two total body photography (TBP) sessions 15+ years apart were included (‘retrospective’ group). To account for a potential selection bias, we also included consecutive patients who had TBP 15+ years ago and consented to undergo follow‐up TBP (‘prospective’ group). We compared baseline and follow‐up torso images on the TBPs and evaluated the number of total, new and disappearing nevi; number of seborrheic keratoses and actinic keratoses; each nevus' diameter at both time points; each nevus' colour change; the presence of clinical atypia; and when dermoscopy was available, the dermoscopic features at each time point.
Results
One hundred six patients were included in the study. Although the average age of the patients was 40 at baseline TBP, most patients developed new nevi between imaging sessions (median 16.4 years) with an average of 2.6 (SD = 4.8) nevi per participant. The average number of disappearing nevi was 0.3 (SD = 0.6). In addition, 62/106 (58%) patients had an absolute increase, and 9/106 (8%) patients had an absolute decrease in their total nevus count. Roughly half (49%: 1416/2890) of the nevi that could be evaluated at both time points increased in diameter by at least 25%. Only 6% (159/2890) of nevi shrunk in diameter by at least 25%. Patients with a history of melanoma had a higher rate of disappearing nevi, and their nevi were more likely to grow. Most nevi demonstrated no significant dermoscopic changes.
Conclusions
High‐risk patients acquire new nevi throughout life with very few nevi disappearing over time. Contrary to prior reports, most nevi in adults increase in diameter, while few nevi shrink.</description><identifier>ISSN: 0926-9959</identifier><identifier>EISSN: 1468-3083</identifier><identifier>DOI: 10.1111/jdv.18470</identifier><identifier>PMID: 35881111</identifier><language>eng</language><publisher>England: John Wiley and Sons Inc</publisher><subject>Adult ; Dermoscopy - methods ; Humans ; Nevus ; Nevus, Epithelioid and Spindle Cell ; Nevus, Pigmented ; Original ; Original and Short Reports ; Skin Neoplasms</subject><ispartof>Journal of the European Academy of Dermatology and Venereology, 2022-12, Vol.36 (12), p.2379-2387</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.</rights><rights>2022 The Authors. Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4150-60c52892447f6e3d6cb2d192748f3e2d47ab2b2afd1a2077105567d954f2c3613</citedby><cites>FETCH-LOGICAL-c4150-60c52892447f6e3d6cb2d192748f3e2d47ab2b2afd1a2077105567d954f2c3613</cites><orcidid>0000-0002-6745-0386 ; 0000-0002-0747-2479 ; 0000-0001-9160-7411 ; 0000-0001-7320-1901 ; 0000-0003-3360-2780</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjdv.18470$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjdv.18470$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35881111$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reiter, O.</creatorcontrib><creatorcontrib>Kurtansky, N.R.</creatorcontrib><creatorcontrib>Musthaq, S.T.</creatorcontrib><creatorcontrib>Dusza, S.</creatorcontrib><creatorcontrib>Halpern, A.C.</creatorcontrib><creatorcontrib>Marchetti, M.A.</creatorcontrib><creatorcontrib>Marghoob, A.A.</creatorcontrib><creatorcontrib>Scope, A.</creatorcontrib><creatorcontrib>Rotemberg, V.</creatorcontrib><title>The long‐term evolution of melanocytic nevi among high‐risk adults</title><title>Journal of the European Academy of Dermatology and Venereology</title><addtitle>J Eur Acad Dermatol Venereol</addtitle><description>Background
There is little understanding regarding the long‐term natural history of melanocytic nevi among adults.
Objective
The objective of the study was to describe the long‐term natural history of individual nevi located on the torso of high‐risk patients.
Methods
All patients attending Memorial Sloan Kettering Cancer Center (MSKCC) who underwent two total body photography (TBP) sessions 15+ years apart were included (‘retrospective’ group). To account for a potential selection bias, we also included consecutive patients who had TBP 15+ years ago and consented to undergo follow‐up TBP (‘prospective’ group). We compared baseline and follow‐up torso images on the TBPs and evaluated the number of total, new and disappearing nevi; number of seborrheic keratoses and actinic keratoses; each nevus' diameter at both time points; each nevus' colour change; the presence of clinical atypia; and when dermoscopy was available, the dermoscopic features at each time point.
Results
One hundred six patients were included in the study. Although the average age of the patients was 40 at baseline TBP, most patients developed new nevi between imaging sessions (median 16.4 years) with an average of 2.6 (SD = 4.8) nevi per participant. The average number of disappearing nevi was 0.3 (SD = 0.6). In addition, 62/106 (58%) patients had an absolute increase, and 9/106 (8%) patients had an absolute decrease in their total nevus count. Roughly half (49%: 1416/2890) of the nevi that could be evaluated at both time points increased in diameter by at least 25%. Only 6% (159/2890) of nevi shrunk in diameter by at least 25%. Patients with a history of melanoma had a higher rate of disappearing nevi, and their nevi were more likely to grow. Most nevi demonstrated no significant dermoscopic changes.
Conclusions
High‐risk patients acquire new nevi throughout life with very few nevi disappearing over time. Contrary to prior reports, most nevi in adults increase in diameter, while few nevi shrink.</description><subject>Adult</subject><subject>Dermoscopy - methods</subject><subject>Humans</subject><subject>Nevus</subject><subject>Nevus, Epithelioid and Spindle Cell</subject><subject>Nevus, Pigmented</subject><subject>Original</subject><subject>Original and Short Reports</subject><subject>Skin Neoplasms</subject><issn>0926-9959</issn><issn>1468-3083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kDtOxDAQhi0EYpeFgguglFAE_IpjN0hoeQuJZqG1HMfZNSQxxEnQdhyBM3ISDIEVFLiZwt98M_MDsIvgIQrv6CHvDxGnKVwDY0QZjwnkZB2MocAsFiIRI7Dl_QOEEKGEb4IRSTj_7ByD89nCRKWr5--vb61pqsj0ruxa6-rIFVFlSlU7vWytjmrT20hVAY0Wdr4IfGP9Y6Tyrmz9NtgoVOnNznedgLvzs9n0Mr65vbiantzEmqIExgzqBHOBKU0LZkjOdIZzJHBKeUEMzmmqMpxhVeRIYZimCCYJS3OR0AJrwhCZgOPB-9Rllcm1qdtGlfKpsZVqltIpK__-1HYh566XgkNKOAyC_W9B454741tZWa9NGe40rvMSM0EFQwKSgB4MqG6c940pVmMQlJ_pyZC7_Mo9sHu_91qRP0EH4GgAXmxplv-b5PXp_aD8AHqbju0</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Reiter, O.</creator><creator>Kurtansky, N.R.</creator><creator>Musthaq, S.T.</creator><creator>Dusza, S.</creator><creator>Halpern, A.C.</creator><creator>Marchetti, M.A.</creator><creator>Marghoob, A.A.</creator><creator>Scope, A.</creator><creator>Rotemberg, V.</creator><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6745-0386</orcidid><orcidid>https://orcid.org/0000-0002-0747-2479</orcidid><orcidid>https://orcid.org/0000-0001-9160-7411</orcidid><orcidid>https://orcid.org/0000-0001-7320-1901</orcidid><orcidid>https://orcid.org/0000-0003-3360-2780</orcidid></search><sort><creationdate>202212</creationdate><title>The long‐term evolution of melanocytic nevi among high‐risk adults</title><author>Reiter, O. ; Kurtansky, N.R. ; Musthaq, S.T. ; Dusza, S. ; Halpern, A.C. ; Marchetti, M.A. ; Marghoob, A.A. ; Scope, A. ; Rotemberg, V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4150-60c52892447f6e3d6cb2d192748f3e2d47ab2b2afd1a2077105567d954f2c3613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Dermoscopy - methods</topic><topic>Humans</topic><topic>Nevus</topic><topic>Nevus, Epithelioid and Spindle Cell</topic><topic>Nevus, Pigmented</topic><topic>Original</topic><topic>Original and Short Reports</topic><topic>Skin Neoplasms</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reiter, O.</creatorcontrib><creatorcontrib>Kurtansky, N.R.</creatorcontrib><creatorcontrib>Musthaq, S.T.</creatorcontrib><creatorcontrib>Dusza, S.</creatorcontrib><creatorcontrib>Halpern, A.C.</creatorcontrib><creatorcontrib>Marchetti, M.A.</creatorcontrib><creatorcontrib>Marghoob, A.A.</creatorcontrib><creatorcontrib>Scope, A.</creatorcontrib><creatorcontrib>Rotemberg, V.</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reiter, O.</au><au>Kurtansky, N.R.</au><au>Musthaq, S.T.</au><au>Dusza, S.</au><au>Halpern, A.C.</au><au>Marchetti, M.A.</au><au>Marghoob, A.A.</au><au>Scope, A.</au><au>Rotemberg, V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The long‐term evolution of melanocytic nevi among high‐risk adults</atitle><jtitle>Journal of the European Academy of Dermatology and Venereology</jtitle><addtitle>J Eur Acad Dermatol Venereol</addtitle><date>2022-12</date><risdate>2022</risdate><volume>36</volume><issue>12</issue><spage>2379</spage><epage>2387</epage><pages>2379-2387</pages><issn>0926-9959</issn><eissn>1468-3083</eissn><abstract>Background
There is little understanding regarding the long‐term natural history of melanocytic nevi among adults.
Objective
The objective of the study was to describe the long‐term natural history of individual nevi located on the torso of high‐risk patients.
Methods
All patients attending Memorial Sloan Kettering Cancer Center (MSKCC) who underwent two total body photography (TBP) sessions 15+ years apart were included (‘retrospective’ group). To account for a potential selection bias, we also included consecutive patients who had TBP 15+ years ago and consented to undergo follow‐up TBP (‘prospective’ group). We compared baseline and follow‐up torso images on the TBPs and evaluated the number of total, new and disappearing nevi; number of seborrheic keratoses and actinic keratoses; each nevus' diameter at both time points; each nevus' colour change; the presence of clinical atypia; and when dermoscopy was available, the dermoscopic features at each time point.
Results
One hundred six patients were included in the study. Although the average age of the patients was 40 at baseline TBP, most patients developed new nevi between imaging sessions (median 16.4 years) with an average of 2.6 (SD = 4.8) nevi per participant. The average number of disappearing nevi was 0.3 (SD = 0.6). In addition, 62/106 (58%) patients had an absolute increase, and 9/106 (8%) patients had an absolute decrease in their total nevus count. Roughly half (49%: 1416/2890) of the nevi that could be evaluated at both time points increased in diameter by at least 25%. Only 6% (159/2890) of nevi shrunk in diameter by at least 25%. Patients with a history of melanoma had a higher rate of disappearing nevi, and their nevi were more likely to grow. Most nevi demonstrated no significant dermoscopic changes.
Conclusions
High‐risk patients acquire new nevi throughout life with very few nevi disappearing over time. Contrary to prior reports, most nevi in adults increase in diameter, while few nevi shrink.</abstract><cop>England</cop><pub>John Wiley and Sons Inc</pub><pmid>35881111</pmid><doi>10.1111/jdv.18470</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-6745-0386</orcidid><orcidid>https://orcid.org/0000-0002-0747-2479</orcidid><orcidid>https://orcid.org/0000-0001-9160-7411</orcidid><orcidid>https://orcid.org/0000-0001-7320-1901</orcidid><orcidid>https://orcid.org/0000-0003-3360-2780</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the European Academy of Dermatology and Venereology, 2022-12, Vol.36 (12), p.2379-2387 |
| issn | 0926-9959 1468-3083 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Adult Dermoscopy - methods Humans Nevus Nevus, Epithelioid and Spindle Cell Nevus, Pigmented Original Original and Short Reports Skin Neoplasms |
| title | The long‐term evolution of melanocytic nevi among high‐risk adults |
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