The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease
Celiac disease is associated with impaired intestinal epithelial barrier integrity. Its consequences affect the nutritional status and quality of life of patients. This study aimed to determine nutritional status, intestinal permeability, and quality of life in people with celiac disease. It was res...
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| Veröffentlicht in: | The Turkish Journal of Gastroenterology 2022-12, Vol.33 (12), p.1043-1049 |
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| creator | Oztekin, Yesim Gunes, Fatma Esra Alahdab, Yesim Ozen |
| description | Celiac disease is associated with impaired intestinal epithelial barrier integrity. Its consequences affect the nutritional status and quality of life of patients. This study aimed to determine nutritional status, intestinal permeability, and quality of life in people with celiac disease. It was researched whether patients who are non-compliant to gluten-free diet have higher serum zonulin levels and intestinal permeability.
The study was completed with 44 celiac patients. Dietary records and a questionnaire were used to evaluate patients' compli ance to the gluten-free diet. Dietary records were analyzed by using a nutrition analysis program. Anthropometric measurements were taken. Body compositions were analyzed to assess the nutritional status of patients. Blood samples were collected and then zonulin levels and total serum proteins were measured to evaluate intestinal permeability. Celiac Disease Questionnaire was used to assess the quality of life scores.
Patients were divided into 2 groups considering compliance to the gluten-free diet and it was found that 17 patients were com pliant to the gluten-free diet, and 27 patients were non-compliant to the gluten-free diet. Serum zonulin, zonulin/total protein ratio, and intestinal permeability were higher in non-compliant to the gluten-free diet group (P < .05). There was no significant difference between anthropometric measurements, Celiac Disease Questionnaire scores, daily energy, and nutrient intakes of groups (P > .05).
The content of a gluten-free diet has a decisive role in the nutritional status and quality of life of celiac patients. Additionally, zonulin levels and intestinal permeability were higher in people with celiac disease who are non-compliant to gluten-free diet. |
| doi_str_mv | 10.5152/tjg.2022.21815 |
| format | Article |
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The study was completed with 44 celiac patients. Dietary records and a questionnaire were used to evaluate patients' compli ance to the gluten-free diet. Dietary records were analyzed by using a nutrition analysis program. Anthropometric measurements were taken. Body compositions were analyzed to assess the nutritional status of patients. Blood samples were collected and then zonulin levels and total serum proteins were measured to evaluate intestinal permeability. Celiac Disease Questionnaire was used to assess the quality of life scores.
Patients were divided into 2 groups considering compliance to the gluten-free diet and it was found that 17 patients were com pliant to the gluten-free diet, and 27 patients were non-compliant to the gluten-free diet. Serum zonulin, zonulin/total protein ratio, and intestinal permeability were higher in non-compliant to the gluten-free diet group (P < .05). There was no significant difference between anthropometric measurements, Celiac Disease Questionnaire scores, daily energy, and nutrient intakes of groups (P > .05).
The content of a gluten-free diet has a decisive role in the nutritional status and quality of life of celiac patients. Additionally, zonulin levels and intestinal permeability were higher in people with celiac disease who are non-compliant to gluten-free diet.</description><identifier>ISSN: 1300-4948</identifier><identifier>EISSN: 2148-5607</identifier><identifier>DOI: 10.5152/tjg.2022.21815</identifier><identifier>PMID: 36510401</identifier><language>eng</language><publisher>Turkey: AVES</publisher><subject>Analysis ; Blood proteins ; Care and treatment ; Celiac Disease ; Complications and side effects ; Diet, Gluten-Free ; GASTROINTESTINAL TRACT ; Gluten ; Gluten-free diet ; Health aspects ; Humans ; Intestines ; Investigations ; Medical research ; Medicine, Experimental ; Nutritional Status ; Original ; Patient compliance ; Permeability ; Physiological aspects ; Quality of Life</subject><ispartof>The Turkish Journal of Gastroenterology, 2022-12, Vol.33 (12), p.1043-1049</ispartof><rights>COPYRIGHT 2022 AVES</rights><rights>Copyright 2022 authors 2022 authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c590t-be915c42e2578a06c32bed5ed6ce6f1c62dbe77dd90e62b33fdb61631f930063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797792/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9797792/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,865,886,27929,27930,53796,53798</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36510401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oztekin, Yesim</creatorcontrib><creatorcontrib>Gunes, Fatma Esra</creatorcontrib><creatorcontrib>Alahdab, Yesim Ozen</creatorcontrib><creatorcontrib>Department of Gastroenterology, Marmara University, Istanbul, Turkey</creatorcontrib><creatorcontrib>Department of Nutrition and Dietetics, Hacettepe University, Ankara, Turkey</creatorcontrib><creatorcontrib>Department of Nutrition and Dietetics, Marmara University, Istanbul, Turkey</creatorcontrib><title>The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease</title><title>The Turkish Journal of Gastroenterology</title><addtitle>Turk J Gastroenterol</addtitle><description>Celiac disease is associated with impaired intestinal epithelial barrier integrity. Its consequences affect the nutritional status and quality of life of patients. This study aimed to determine nutritional status, intestinal permeability, and quality of life in people with celiac disease. It was researched whether patients who are non-compliant to gluten-free diet have higher serum zonulin levels and intestinal permeability.
The study was completed with 44 celiac patients. Dietary records and a questionnaire were used to evaluate patients' compli ance to the gluten-free diet. Dietary records were analyzed by using a nutrition analysis program. Anthropometric measurements were taken. Body compositions were analyzed to assess the nutritional status of patients. Blood samples were collected and then zonulin levels and total serum proteins were measured to evaluate intestinal permeability. Celiac Disease Questionnaire was used to assess the quality of life scores.
Patients were divided into 2 groups considering compliance to the gluten-free diet and it was found that 17 patients were com pliant to the gluten-free diet, and 27 patients were non-compliant to the gluten-free diet. Serum zonulin, zonulin/total protein ratio, and intestinal permeability were higher in non-compliant to the gluten-free diet group (P < .05). There was no significant difference between anthropometric measurements, Celiac Disease Questionnaire scores, daily energy, and nutrient intakes of groups (P > .05).
The content of a gluten-free diet has a decisive role in the nutritional status and quality of life of celiac patients. Additionally, zonulin levels and intestinal permeability were higher in people with celiac disease who are non-compliant to gluten-free diet.</description><subject>Analysis</subject><subject>Blood proteins</subject><subject>Care and treatment</subject><subject>Celiac Disease</subject><subject>Complications and side effects</subject><subject>Diet, Gluten-Free</subject><subject>GASTROINTESTINAL TRACT</subject><subject>Gluten</subject><subject>Gluten-free diet</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Intestines</subject><subject>Investigations</subject><subject>Medical research</subject><subject>Medicine, Experimental</subject><subject>Nutritional Status</subject><subject>Original</subject><subject>Patient compliance</subject><subject>Permeability</subject><subject>Physiological aspects</subject><subject>Quality of Life</subject><issn>1300-4948</issn><issn>2148-5607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>DOA</sourceid><recordid>eNqNkstvEzEQxlcIREPhyhGtxKWHJvj9uCBV4RUp4iFyt7z2bOJosw5rb1H_e7xNqajggHywPP7NN57xV1UvMVpwzMmbvN8uCCJkQbDC_FE1I5ipORdIPq5mmCI0Z5qps-pZSnuEqMKCPK3OqOAYMYRnVdrsoF7115By2NocYl_Htv485iFMB9vV37PNY7osUJ6gKfQVhgPYJnQh31zWtvf1t9FOhyl3HVqoQ1-geOyg_hnyrl5CF6yr34UENsHz6klruwQv7vbzavPh_Wb5ab7-8nG1vFrPHdcozxvQmDtGgHCpLBKOkgY8By8ciBY7QXwDUnqvEQjSUNr6RmBBcatL34KeV6uTrI92b45DONjhxkQbzG0gDltjhxxcB8Yx2zoApRBmzAuvGXNKKsRl03rladF6e9I6js0BvIM-D7Z7IPrwpg87s43XRkstpSZF4OJOYIg_xjJIcwjJQdfZHuKYDJGcIaYon2q9PqFbW54W-jYWRTfh5krS8m1aUFSoxT-osjwcgos9tKHESwIpvkBM_3_CXxXcEFMaoL1vFyMzmc8U85nJfObWfCXh1Z9Dusd_u43-AsjC1VQ</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Oztekin, Yesim</creator><creator>Gunes, Fatma Esra</creator><creator>Alahdab, Yesim Ozen</creator><general>AVES</general><general>Turkish Society of Gastroenterology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20221201</creationdate><title>The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease</title><author>Oztekin, Yesim ; Gunes, Fatma Esra ; Alahdab, Yesim Ozen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c590t-be915c42e2578a06c32bed5ed6ce6f1c62dbe77dd90e62b33fdb61631f930063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Blood proteins</topic><topic>Care and treatment</topic><topic>Celiac Disease</topic><topic>Complications and side effects</topic><topic>Diet, Gluten-Free</topic><topic>GASTROINTESTINAL TRACT</topic><topic>Gluten</topic><topic>Gluten-free diet</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Intestines</topic><topic>Investigations</topic><topic>Medical research</topic><topic>Medicine, Experimental</topic><topic>Nutritional Status</topic><topic>Original</topic><topic>Patient compliance</topic><topic>Permeability</topic><topic>Physiological aspects</topic><topic>Quality of Life</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oztekin, Yesim</creatorcontrib><creatorcontrib>Gunes, Fatma Esra</creatorcontrib><creatorcontrib>Alahdab, Yesim Ozen</creatorcontrib><creatorcontrib>Department of Gastroenterology, Marmara University, Istanbul, Turkey</creatorcontrib><creatorcontrib>Department of Nutrition and Dietetics, Hacettepe University, Ankara, Turkey</creatorcontrib><creatorcontrib>Department of Nutrition and Dietetics, Marmara University, Istanbul, Turkey</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>The Turkish Journal of Gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oztekin, Yesim</au><au>Gunes, Fatma Esra</au><au>Alahdab, Yesim Ozen</au><aucorp>Department of Gastroenterology, Marmara University, Istanbul, Turkey</aucorp><aucorp>Department of Nutrition and Dietetics, Hacettepe University, Ankara, Turkey</aucorp><aucorp>Department of Nutrition and Dietetics, Marmara University, Istanbul, Turkey</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease</atitle><jtitle>The Turkish Journal of Gastroenterology</jtitle><addtitle>Turk J Gastroenterol</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>33</volume><issue>12</issue><spage>1043</spage><epage>1049</epage><pages>1043-1049</pages><issn>1300-4948</issn><eissn>2148-5607</eissn><abstract>Celiac disease is associated with impaired intestinal epithelial barrier integrity. Its consequences affect the nutritional status and quality of life of patients. This study aimed to determine nutritional status, intestinal permeability, and quality of life in people with celiac disease. It was researched whether patients who are non-compliant to gluten-free diet have higher serum zonulin levels and intestinal permeability.
The study was completed with 44 celiac patients. Dietary records and a questionnaire were used to evaluate patients' compli ance to the gluten-free diet. Dietary records were analyzed by using a nutrition analysis program. Anthropometric measurements were taken. Body compositions were analyzed to assess the nutritional status of patients. Blood samples were collected and then zonulin levels and total serum proteins were measured to evaluate intestinal permeability. Celiac Disease Questionnaire was used to assess the quality of life scores.
Patients were divided into 2 groups considering compliance to the gluten-free diet and it was found that 17 patients were com pliant to the gluten-free diet, and 27 patients were non-compliant to the gluten-free diet. Serum zonulin, zonulin/total protein ratio, and intestinal permeability were higher in non-compliant to the gluten-free diet group (P < .05). There was no significant difference between anthropometric measurements, Celiac Disease Questionnaire scores, daily energy, and nutrient intakes of groups (P > .05).
The content of a gluten-free diet has a decisive role in the nutritional status and quality of life of celiac patients. Additionally, zonulin levels and intestinal permeability were higher in people with celiac disease who are non-compliant to gluten-free diet.</abstract><cop>Turkey</cop><pub>AVES</pub><pmid>36510401</pmid><doi>10.5152/tjg.2022.21815</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Turkish Journal of Gastroenterology, 2022-12, Vol.33 (12), p.1043-1049 |
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| subjects | Analysis Blood proteins Care and treatment Celiac Disease Complications and side effects Diet, Gluten-Free GASTROINTESTINAL TRACT Gluten Gluten-free diet Health aspects Humans Intestines Investigations Medical research Medicine, Experimental Nutritional Status Original Patient compliance Permeability Physiological aspects Quality of Life |
| title | The Investigation of Nutritional Status, Intestinal Permeability, and Quality of Life in People with Celiac Disease |
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