Associations of coagulation factors IX and XI levels with incident coronary heart disease and ischemic stroke: the REGARDS study
Essentials Coagulation factors (F) IX and XI have been implicated in cardiovascular disease (CVD) risk. We studied associations of FIX and FXI with incident coronary heart disease (CHD) and stroke. Higher FIX antigen was associated with incident CHD risk in blacks but not whites. Higher levels of FI...
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| Veröffentlicht in: | Journal of thrombosis and haemostasis 2017-06, Vol.15 (6), p.1086-1094 |
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| creator | Olson, N. C. Cushman, M. Judd, S. E. Kissela, B. M. Safford, M. M. Howard, G. Zakai, N. A. |
| description | Essentials
Coagulation factors (F) IX and XI have been implicated in cardiovascular disease (CVD) risk.
We studied associations of FIX and FXI with incident coronary heart disease (CHD) and stroke.
Higher FIX antigen was associated with incident CHD risk in blacks but not whites.
Higher levels of FIX antigen may be a CHD risk factor among blacks.
Summary
Background
Recent studies have suggested the importance of coagulation factor IX and FXI in cardiovascular disease (CVD) risk.
Objectives
To determine whether basal levels of FIX or FXI antigen were associated with the risk of incident coronary heart disease (CHD) or ischemic stroke.
Patients/Methods
The REasons for Geographic And Racial Differences in Stroke (REGARDS) study recruited 30 239 participants across the contiguous USA between 2003 and 2007. In a case–cohort study within REGARDS, FIX and FXI antigen were measured in participants with incident CHD (n = 609), in participants with incident ischemic stroke (n = 538), and in a cohort random sample (n = 1038). Hazard ratios (HRs) for CHD and ischemic stroke risk were estimated with Cox models per standard deviation higher FIX or FXI level, adjusted for CVD risk factors.
Results
In models adjusting for CHD risk factors, higher FIX levels were associated with incident CHD risk (HR 1.19; 95% confidence interval [CI] 1.01–1.40) and the relationship of higher FXI levels was slightly weaker (HR 1.15; 95% CI 0.97–1.36). When stratified by race, the HR of FIX was higher in blacks (HR 1.39; 95% CI 1.10–1.75) than in whites (HR 1.06; 95% CI 0.86–1.31). After adjustment for stroke risk factors, there was no longer an association of FIX levels with ischemic stroke, whereas the association of FXI levels with ischemic stroke was slightly attenuated.
Conclusions
Higher FIX antigen levels were associated with incident CHD in blacks but not in whites. FIX levels may increase CHD risk among blacks. |
| doi_str_mv | 10.1111/jth.13698 |
| format | Article |
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Coagulation factors (F) IX and XI have been implicated in cardiovascular disease (CVD) risk.
We studied associations of FIX and FXI with incident coronary heart disease (CHD) and stroke.
Higher FIX antigen was associated with incident CHD risk in blacks but not whites.
Higher levels of FIX antigen may be a CHD risk factor among blacks.
Summary
Background
Recent studies have suggested the importance of coagulation factor IX and FXI in cardiovascular disease (CVD) risk.
Objectives
To determine whether basal levels of FIX or FXI antigen were associated with the risk of incident coronary heart disease (CHD) or ischemic stroke.
Patients/Methods
The REasons for Geographic And Racial Differences in Stroke (REGARDS) study recruited 30 239 participants across the contiguous USA between 2003 and 2007. In a case–cohort study within REGARDS, FIX and FXI antigen were measured in participants with incident CHD (n = 609), in participants with incident ischemic stroke (n = 538), and in a cohort random sample (n = 1038). Hazard ratios (HRs) for CHD and ischemic stroke risk were estimated with Cox models per standard deviation higher FIX or FXI level, adjusted for CVD risk factors.
Results
In models adjusting for CHD risk factors, higher FIX levels were associated with incident CHD risk (HR 1.19; 95% confidence interval [CI] 1.01–1.40) and the relationship of higher FXI levels was slightly weaker (HR 1.15; 95% CI 0.97–1.36). When stratified by race, the HR of FIX was higher in blacks (HR 1.39; 95% CI 1.10–1.75) than in whites (HR 1.06; 95% CI 0.86–1.31). After adjustment for stroke risk factors, there was no longer an association of FIX levels with ischemic stroke, whereas the association of FXI levels with ischemic stroke was slightly attenuated.
Conclusions
Higher FIX antigen levels were associated with incident CHD in blacks but not in whites. FIX levels may increase CHD risk among blacks.</description><identifier>ISSN: 1538-7933</identifier><identifier>ISSN: 1538-7836</identifier><identifier>EISSN: 1538-7836</identifier><identifier>DOI: 10.1111/jth.13698</identifier><identifier>PMID: 28393470</identifier><language>eng</language><publisher>England: Elsevier Limited</publisher><subject>Aged ; Antigens ; Black or African American ; Black People ; C-Reactive Protein - metabolism ; Cardiovascular disease ; Cardiovascular diseases ; Coagulation ; Coagulation factor IX ; coagulation factor XI ; Coagulation factors ; Coronary artery disease ; Coronary Disease - blood ; Coronary Disease - ethnology ; coronary heart disease ; Factor IX - metabolism ; Factor XI - metabolism ; Female ; Fibrin Fibrinogen Degradation Products - metabolism ; FIX antigen ; Health risk assessment ; Heart diseases ; Humans ; Ischemia ; Male ; Middle Aged ; Myocardial Ischemia - blood ; Myocardial Ischemia - ethnology ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; Standard deviation ; Stroke ; Stroke - genetics ; Stroke - metabolism ; Treatment Outcome ; United States ; White People ; Xenografts</subject><ispartof>Journal of thrombosis and haemostasis, 2017-06, Vol.15 (6), p.1086-1094</ispartof><rights>2017 International Society on Thrombosis and Haemostasis</rights><rights>2017 International Society on Thrombosis and Haemostasis.</rights><rights>Copyright © 2017 International Society on Thrombosis and Haemostasis</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4438-6d9e8f4f38e8132ef24fdbdb1a7280d15b48a19178c7cc3c7de057b199f967b93</citedby><cites>FETCH-LOGICAL-c4438-6d9e8f4f38e8132ef24fdbdb1a7280d15b48a19178c7cc3c7de057b199f967b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28393470$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olson, N. C.</creatorcontrib><creatorcontrib>Cushman, M.</creatorcontrib><creatorcontrib>Judd, S. E.</creatorcontrib><creatorcontrib>Kissela, B. M.</creatorcontrib><creatorcontrib>Safford, M. M.</creatorcontrib><creatorcontrib>Howard, G.</creatorcontrib><creatorcontrib>Zakai, N. A.</creatorcontrib><title>Associations of coagulation factors IX and XI levels with incident coronary heart disease and ischemic stroke: the REGARDS study</title><title>Journal of thrombosis and haemostasis</title><addtitle>J Thromb Haemost</addtitle><description>Essentials
Coagulation factors (F) IX and XI have been implicated in cardiovascular disease (CVD) risk.
We studied associations of FIX and FXI with incident coronary heart disease (CHD) and stroke.
Higher FIX antigen was associated with incident CHD risk in blacks but not whites.
Higher levels of FIX antigen may be a CHD risk factor among blacks.
Summary
Background
Recent studies have suggested the importance of coagulation factor IX and FXI in cardiovascular disease (CVD) risk.
Objectives
To determine whether basal levels of FIX or FXI antigen were associated with the risk of incident coronary heart disease (CHD) or ischemic stroke.
Patients/Methods
The REasons for Geographic And Racial Differences in Stroke (REGARDS) study recruited 30 239 participants across the contiguous USA between 2003 and 2007. In a case–cohort study within REGARDS, FIX and FXI antigen were measured in participants with incident CHD (n = 609), in participants with incident ischemic stroke (n = 538), and in a cohort random sample (n = 1038). Hazard ratios (HRs) for CHD and ischemic stroke risk were estimated with Cox models per standard deviation higher FIX or FXI level, adjusted for CVD risk factors.
Results
In models adjusting for CHD risk factors, higher FIX levels were associated with incident CHD risk (HR 1.19; 95% confidence interval [CI] 1.01–1.40) and the relationship of higher FXI levels was slightly weaker (HR 1.15; 95% CI 0.97–1.36). When stratified by race, the HR of FIX was higher in blacks (HR 1.39; 95% CI 1.10–1.75) than in whites (HR 1.06; 95% CI 0.86–1.31). After adjustment for stroke risk factors, there was no longer an association of FIX levels with ischemic stroke, whereas the association of FXI levels with ischemic stroke was slightly attenuated.
Conclusions
Higher FIX antigen levels were associated with incident CHD in blacks but not in whites. FIX levels may increase CHD risk among blacks.</description><subject>Aged</subject><subject>Antigens</subject><subject>Black or African American</subject><subject>Black People</subject><subject>C-Reactive Protein - metabolism</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular diseases</subject><subject>Coagulation</subject><subject>Coagulation factor IX</subject><subject>coagulation factor XI</subject><subject>Coagulation factors</subject><subject>Coronary artery disease</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - ethnology</subject><subject>coronary heart disease</subject><subject>Factor IX - metabolism</subject><subject>Factor XI - metabolism</subject><subject>Female</subject><subject>Fibrin Fibrinogen Degradation Products - metabolism</subject><subject>FIX antigen</subject><subject>Health risk assessment</subject><subject>Heart diseases</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia - blood</subject><subject>Myocardial Ischemia - ethnology</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Standard deviation</subject><subject>Stroke</subject><subject>Stroke - genetics</subject><subject>Stroke - metabolism</subject><subject>Treatment Outcome</subject><subject>United States</subject><subject>White People</subject><subject>Xenografts</subject><issn>1538-7933</issn><issn>1538-7836</issn><issn>1538-7836</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kV1LHDEYhUOp1I_2on-gBHrTXqwmk9lJ0gthsVZXhIK14F3IJG-cbGcnNskoe-dPb9xVsYXmJl_PeziHg9B7SvZpWQeL3O1T1kjxCu3QKRMTLljz-uksGdtGuyktCKFyWpE3aLsSTLKakx10P0spGK-zD0PCwWET9PXYr-_YaZNDTHh-hfVg8dUc93ALfcJ3PnfYD8ZbGHIZiWHQcYU70DFj6xPoBOsRn0wHS29wyjH8gi84d4Avjk9mF19_lLfRrt6iLaf7BO8e9z3089vx5dHp5Pz7yfxodj4xdV1SNFaCcLVjAgRlFbiqdra1LdW8EsTSaVsLTSXlwnBjmOEWyJS3VEonG95KtocON7o3Y7sEa4rxqHt1E_2yWFdBe_X3z-A7dR1uleSSk4oXgU-PAjH8HiFltSzpoO_1AGFMigrRsIZUkhT04z_oIoxxKPEUlaSpSgDWFOrzhjIxpBTBPZuhRD30qkqvat1rYT-8dP9MPhVZgIMNcOd7WP1fSZ1dnm4k_wCSlq57</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Olson, N. C.</creator><creator>Cushman, M.</creator><creator>Judd, S. E.</creator><creator>Kissela, B. M.</creator><creator>Safford, M. M.</creator><creator>Howard, G.</creator><creator>Zakai, N. A.</creator><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201706</creationdate><title>Associations of coagulation factors IX and XI levels with incident coronary heart disease and ischemic stroke: the REGARDS study</title><author>Olson, N. C. ; Cushman, M. ; Judd, S. E. ; Kissela, B. M. ; Safford, M. M. ; Howard, G. ; Zakai, N. A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4438-6d9e8f4f38e8132ef24fdbdb1a7280d15b48a19178c7cc3c7de057b199f967b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Antigens</topic><topic>Black or African American</topic><topic>Black People</topic><topic>C-Reactive Protein - metabolism</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Coagulation</topic><topic>Coagulation factor IX</topic><topic>coagulation factor XI</topic><topic>Coagulation factors</topic><topic>Coronary artery disease</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - ethnology</topic><topic>coronary heart disease</topic><topic>Factor IX - metabolism</topic><topic>Factor XI - metabolism</topic><topic>Female</topic><topic>Fibrin Fibrinogen Degradation Products - metabolism</topic><topic>FIX antigen</topic><topic>Health risk assessment</topic><topic>Heart diseases</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Ischemia - blood</topic><topic>Myocardial Ischemia - ethnology</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Standard deviation</topic><topic>Stroke</topic><topic>Stroke - genetics</topic><topic>Stroke - metabolism</topic><topic>Treatment Outcome</topic><topic>United States</topic><topic>White People</topic><topic>Xenografts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olson, N. C.</creatorcontrib><creatorcontrib>Cushman, M.</creatorcontrib><creatorcontrib>Judd, S. E.</creatorcontrib><creatorcontrib>Kissela, B. M.</creatorcontrib><creatorcontrib>Safford, M. M.</creatorcontrib><creatorcontrib>Howard, G.</creatorcontrib><creatorcontrib>Zakai, N. A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of thrombosis and haemostasis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olson, N. C.</au><au>Cushman, M.</au><au>Judd, S. E.</au><au>Kissela, B. M.</au><au>Safford, M. M.</au><au>Howard, G.</au><au>Zakai, N. A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Associations of coagulation factors IX and XI levels with incident coronary heart disease and ischemic stroke: the REGARDS study</atitle><jtitle>Journal of thrombosis and haemostasis</jtitle><addtitle>J Thromb Haemost</addtitle><date>2017-06</date><risdate>2017</risdate><volume>15</volume><issue>6</issue><spage>1086</spage><epage>1094</epage><pages>1086-1094</pages><issn>1538-7933</issn><issn>1538-7836</issn><eissn>1538-7836</eissn><abstract>Essentials
Coagulation factors (F) IX and XI have been implicated in cardiovascular disease (CVD) risk.
We studied associations of FIX and FXI with incident coronary heart disease (CHD) and stroke.
Higher FIX antigen was associated with incident CHD risk in blacks but not whites.
Higher levels of FIX antigen may be a CHD risk factor among blacks.
Summary
Background
Recent studies have suggested the importance of coagulation factor IX and FXI in cardiovascular disease (CVD) risk.
Objectives
To determine whether basal levels of FIX or FXI antigen were associated with the risk of incident coronary heart disease (CHD) or ischemic stroke.
Patients/Methods
The REasons for Geographic And Racial Differences in Stroke (REGARDS) study recruited 30 239 participants across the contiguous USA between 2003 and 2007. In a case–cohort study within REGARDS, FIX and FXI antigen were measured in participants with incident CHD (n = 609), in participants with incident ischemic stroke (n = 538), and in a cohort random sample (n = 1038). Hazard ratios (HRs) for CHD and ischemic stroke risk were estimated with Cox models per standard deviation higher FIX or FXI level, adjusted for CVD risk factors.
Results
In models adjusting for CHD risk factors, higher FIX levels were associated with incident CHD risk (HR 1.19; 95% confidence interval [CI] 1.01–1.40) and the relationship of higher FXI levels was slightly weaker (HR 1.15; 95% CI 0.97–1.36). When stratified by race, the HR of FIX was higher in blacks (HR 1.39; 95% CI 1.10–1.75) than in whites (HR 1.06; 95% CI 0.86–1.31). After adjustment for stroke risk factors, there was no longer an association of FIX levels with ischemic stroke, whereas the association of FXI levels with ischemic stroke was slightly attenuated.
Conclusions
Higher FIX antigen levels were associated with incident CHD in blacks but not in whites. FIX levels may increase CHD risk among blacks.</abstract><cop>England</cop><pub>Elsevier Limited</pub><pmid>28393470</pmid><doi>10.1111/jth.13698</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged Antigens Black or African American Black People C-Reactive Protein - metabolism Cardiovascular disease Cardiovascular diseases Coagulation Coagulation factor IX coagulation factor XI Coagulation factors Coronary artery disease Coronary Disease - blood Coronary Disease - ethnology coronary heart disease Factor IX - metabolism Factor XI - metabolism Female Fibrin Fibrinogen Degradation Products - metabolism FIX antigen Health risk assessment Heart diseases Humans Ischemia Male Middle Aged Myocardial Ischemia - blood Myocardial Ischemia - ethnology Proportional Hazards Models Prospective Studies Risk Factors Standard deviation Stroke Stroke - genetics Stroke - metabolism Treatment Outcome United States White People Xenografts |
| title | Associations of coagulation factors IX and XI levels with incident coronary heart disease and ischemic stroke: the REGARDS study |
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