Thermal ablation for cervical lymph node metastasis from papillary thyroid carcinoma: A meta-analysis
Traditionally, surgery has been the standard treatment for cervical lymph node metastasis in patients with papillary thyroid carcinoma (PTC). However, thermal ablation is currently recommended by several guidelines. This study aimed to evaluate the efficacy and safety of thermal ablation for lymph n...
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| Veröffentlicht in: | Medicine (Baltimore) 2022-12, Vol.101 (51), p.e32193-e32193 |
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| creator | Zhu, Yun Wang, Yueai Liu, Fang Liao, Yacong Wang, Qun Xiao, Xiaoyi |
| description | Traditionally, surgery has been the standard treatment for cervical lymph node metastasis in patients with papillary thyroid carcinoma (PTC). However, thermal ablation is currently recommended by several guidelines. This study aimed to evaluate the efficacy and safety of thermal ablation for lymph node metastasis in patients with PTC.
We searched PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases until March 2022 to collect studies on thermal ablation (including radiofrequency, microwave, and laser ablations) for cervical lymph node metastasis from PTC.
A total of 190 patients were included, ranging from 5 to 39 in each study, with a sex ratio (male/female) ranging from 1/4 to 17/20, an average age ranging from 15.6 ± 3.0 to 62.3 ± 13.2 (yr), and a total of 270 cervical lymph nodes, ranging from 8 to 98. The follow-up results showed that thermal ablation significantly reduced the maximum diameter and volume of metastatic lymph nodes in PTC (P |
| doi_str_mv | 10.1097/MD.0000000000032193 |
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We searched PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases until March 2022 to collect studies on thermal ablation (including radiofrequency, microwave, and laser ablations) for cervical lymph node metastasis from PTC.
A total of 190 patients were included, ranging from 5 to 39 in each study, with a sex ratio (male/female) ranging from 1/4 to 17/20, an average age ranging from 15.6 ± 3.0 to 62.3 ± 13.2 (yr), and a total of 270 cervical lymph nodes, ranging from 8 to 98. The follow-up results showed that thermal ablation significantly reduced the maximum diameter and volume of metastatic lymph nodes in PTC (P < .01). The pooled complete disappearance rate was 86% (95% confidence interval 79% to 93%). Thyroglobulin levels were significantly lower after surgery (P < .01). No major complications occurred, and the combined voice change rate was as low as 1% [CI 0% to 3%].
Our meta-analysis showed that thermal ablation is an effective and safe method for the treatment of cervical lymph node metastases from PTC. Considering the limitations of this study, more prospective, multicenter, large-sample studies are needed in the future.</description><identifier>ISSN: 1536-5964</identifier><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000032193</identifier><identifier>PMID: 36595775</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Female ; Humans ; Lymph Nodes - pathology ; Lymph Nodes - surgery ; Lymphatic Metastasis - pathology ; Male ; Multicenter Studies as Topic ; Prospective Studies ; Retrospective Studies ; Systematic Review and Meta-Analysis ; Thyroid Cancer, Papillary - pathology ; Thyroid Cancer, Papillary - surgery ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery</subject><ispartof>Medicine (Baltimore), 2022-12, Vol.101 (51), p.e32193-e32193</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4006-5be70e55bb54118b43a77d2b7fd8e92e9ce28bb6b064a76a6f40acda573693243</cites><orcidid>0000-0001-6851-644 ; 0000-0001-6851-644X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794307/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9794307/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36595775$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhu, Yun</creatorcontrib><creatorcontrib>Wang, Yueai</creatorcontrib><creatorcontrib>Liu, Fang</creatorcontrib><creatorcontrib>Liao, Yacong</creatorcontrib><creatorcontrib>Wang, Qun</creatorcontrib><creatorcontrib>Xiao, Xiaoyi</creatorcontrib><title>Thermal ablation for cervical lymph node metastasis from papillary thyroid carcinoma: A meta-analysis</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>Traditionally, surgery has been the standard treatment for cervical lymph node metastasis in patients with papillary thyroid carcinoma (PTC). However, thermal ablation is currently recommended by several guidelines. This study aimed to evaluate the efficacy and safety of thermal ablation for lymph node metastasis in patients with PTC.
We searched PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases until March 2022 to collect studies on thermal ablation (including radiofrequency, microwave, and laser ablations) for cervical lymph node metastasis from PTC.
A total of 190 patients were included, ranging from 5 to 39 in each study, with a sex ratio (male/female) ranging from 1/4 to 17/20, an average age ranging from 15.6 ± 3.0 to 62.3 ± 13.2 (yr), and a total of 270 cervical lymph nodes, ranging from 8 to 98. The follow-up results showed that thermal ablation significantly reduced the maximum diameter and volume of metastatic lymph nodes in PTC (P < .01). The pooled complete disappearance rate was 86% (95% confidence interval 79% to 93%). Thyroglobulin levels were significantly lower after surgery (P < .01). No major complications occurred, and the combined voice change rate was as low as 1% [CI 0% to 3%].
Our meta-analysis showed that thermal ablation is an effective and safe method for the treatment of cervical lymph node metastases from PTC. Considering the limitations of this study, more prospective, multicenter, large-sample studies are needed in the future.</description><subject>Female</subject><subject>Humans</subject><subject>Lymph Nodes - pathology</subject><subject>Lymph Nodes - surgery</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Multicenter Studies as Topic</subject><subject>Prospective Studies</subject><subject>Retrospective Studies</subject><subject>Systematic Review and Meta-Analysis</subject><subject>Thyroid Cancer, Papillary - pathology</subject><subject>Thyroid Cancer, Papillary - surgery</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><issn>1536-5964</issn><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdUU1vFSEUJUZja_UXmBiWbqbyzcOFSdPWj6SNm7omwNxxUGYYYV6b9--lfbVWuSSXwDmHc3MQek3JMSVGv7s8OyZ_F2fU8CfokEquOmmUeProfIBe1PqDEMo1E8_RAVfSSK3lIYKrEcrkEnY-uTXmGQ-54ADlOoZ2m3bTMuI594AnWF1tO1Y8lDzhxS0xJVd2eB13JcceB1dCnPPk3uOTO3jnZpd2jfESPRtcqvDqvh-hbx_Pr04_dxdfP305PbnogiCkWfWgCUjpvRSUbrzgTuueeT30GzAMTAC28V55ooTTyqlBEBd6JzVXhjPBj9CHve6y9RP0Aea1uGSXEqdm1GYX7b8vcxzt93xtjTaCE90E3t4LlPxrC3W1U6wB2pwz5G21TCuyoa1Mg_I9NJRca4Hh4RtK7G1A9vLM_h9QY7157PCB8yeRBhB7wE1OK5T6M21voNgRXFrHOz2pDesYYYwyxkl3K634b4l8nZA</recordid><startdate>20221223</startdate><enddate>20221223</enddate><creator>Zhu, Yun</creator><creator>Wang, Yueai</creator><creator>Liu, Fang</creator><creator>Liao, Yacong</creator><creator>Wang, Qun</creator><creator>Xiao, Xiaoyi</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6851-644</orcidid><orcidid>https://orcid.org/0000-0001-6851-644X</orcidid></search><sort><creationdate>20221223</creationdate><title>Thermal ablation for cervical lymph node metastasis from papillary thyroid carcinoma: A meta-analysis</title><author>Zhu, Yun ; Wang, Yueai ; Liu, Fang ; Liao, Yacong ; Wang, Qun ; Xiao, Xiaoyi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4006-5be70e55bb54118b43a77d2b7fd8e92e9ce28bb6b064a76a6f40acda573693243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Female</topic><topic>Humans</topic><topic>Lymph Nodes - pathology</topic><topic>Lymph Nodes - surgery</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Multicenter Studies as Topic</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><topic>Systematic Review and Meta-Analysis</topic><topic>Thyroid Cancer, Papillary - pathology</topic><topic>Thyroid Cancer, Papillary - surgery</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhu, Yun</creatorcontrib><creatorcontrib>Wang, Yueai</creatorcontrib><creatorcontrib>Liu, Fang</creatorcontrib><creatorcontrib>Liao, Yacong</creatorcontrib><creatorcontrib>Wang, Qun</creatorcontrib><creatorcontrib>Xiao, Xiaoyi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Yun</au><au>Wang, Yueai</au><au>Liu, Fang</au><au>Liao, Yacong</au><au>Wang, Qun</au><au>Xiao, Xiaoyi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Thermal ablation for cervical lymph node metastasis from papillary thyroid carcinoma: A meta-analysis</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2022-12-23</date><risdate>2022</risdate><volume>101</volume><issue>51</issue><spage>e32193</spage><epage>e32193</epage><pages>e32193-e32193</pages><issn>1536-5964</issn><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>Traditionally, surgery has been the standard treatment for cervical lymph node metastasis in patients with papillary thyroid carcinoma (PTC). However, thermal ablation is currently recommended by several guidelines. This study aimed to evaluate the efficacy and safety of thermal ablation for lymph node metastasis in patients with PTC.
We searched PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases until March 2022 to collect studies on thermal ablation (including radiofrequency, microwave, and laser ablations) for cervical lymph node metastasis from PTC.
A total of 190 patients were included, ranging from 5 to 39 in each study, with a sex ratio (male/female) ranging from 1/4 to 17/20, an average age ranging from 15.6 ± 3.0 to 62.3 ± 13.2 (yr), and a total of 270 cervical lymph nodes, ranging from 8 to 98. The follow-up results showed that thermal ablation significantly reduced the maximum diameter and volume of metastatic lymph nodes in PTC (P < .01). The pooled complete disappearance rate was 86% (95% confidence interval 79% to 93%). Thyroglobulin levels were significantly lower after surgery (P < .01). No major complications occurred, and the combined voice change rate was as low as 1% [CI 0% to 3%].
Our meta-analysis showed that thermal ablation is an effective and safe method for the treatment of cervical lymph node metastases from PTC. Considering the limitations of this study, more prospective, multicenter, large-sample studies are needed in the future.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>36595775</pmid><doi>10.1097/MD.0000000000032193</doi><orcidid>https://orcid.org/0000-0001-6851-644</orcidid><orcidid>https://orcid.org/0000-0001-6851-644X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Wolters Kluwer Open Health; IngentaConnect Free/Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Female Humans Lymph Nodes - pathology Lymph Nodes - surgery Lymphatic Metastasis - pathology Male Multicenter Studies as Topic Prospective Studies Retrospective Studies Systematic Review and Meta-Analysis Thyroid Cancer, Papillary - pathology Thyroid Cancer, Papillary - surgery Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery |
| title | Thermal ablation for cervical lymph node metastasis from papillary thyroid carcinoma: A meta-analysis |
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