PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

Combination therapy with PD-1 blockade and IL-2 is highly effective during chronic lymphocytic choriomeningitis virus infection 1 . Here we examine the underlying basis for this synergy. We show that PD-1 + IL-2 combination therapy, in contrast to PD-1 monotherapy, substantially changes the differen...

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Veröffentlicht in:	Nature (London) 2022-10, Vol.610 (7930), p.173-181
Hauptverfasser:	Hashimoto, Masao, Araki, Koichi, Cardenas, Maria A., Li, Peng, Jadhav, Rohit R., Kissick, Haydn T., Hudson, William H., McGuire, Donald J., Obeng, Rebecca C., Wieland, Andreas, Lee, Judong, McManus, Daniel T., Ross, James L., Im, Se Jin, Lee, Junghwa, Lin, Jian-Xin, Hu, Bin, West, Erin E., Scharer, Christopher D., Freeman, Gordon J., Sharpe, Arlene H., Ramalingam, Suresh S., Pellerin, Alex, Teichgräber, Volker, Greenleaf, William J., Klein, Christian, Goronzy, Jorg J., Umaña, Pablo, Leonard, Warren J., Smith, Kendall A., Ahmed, Rafi
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/127/1213 631/250/1619/554/1834 631/250/2152/1566/2493 631/250/251 631/250/255/2514 Antibodies Cancer therapies CD122 antigen CD25 antigen CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Cell Differentiation - drug effects Clinical trials Combination therapy Cytokines Differentiation Drug Therapy, Combination Effector cells Gene expression Hepatocyte nuclear factor 1 Humanities and Social Sciences Humans Immunotherapy Infections Interleukin 2 Interleukin Receptor Common gamma Subunit Interleukin-2 - immunology Interleukin-2 - pharmacology Interleukin-2 - therapeutic use Interleukin-2 Receptor alpha Subunit Interleukin-2 Receptor beta Subunit Lymphocytes Lymphocytes T Lymphocytic Choriomeningitis - drug therapy Lymphocytic Choriomeningitis - immunology multidisciplinary PD-1 protein Population Programmed Cell Death 1 Receptor - antagonists & inhibitors Science Science (multidisciplinary) Stems Synergistic effect T Cell Transcription Factor 1 Therapy Viral infections Viruses
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