Halofuginone, a promising drug for treatment of pulmonary hypertension

Background and Purpose Halofuginone is a febrifugine derivative originally isolated from Chinese traditional herb Chang Shan that exhibits anti‐hypertrophic, anti‐fibrotic and anti‐proliferative effects. We sought to investigate whether halofuginone induced pulmonary vasodilation and attenuates chro...

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Veröffentlicht in:	British journal of pharmacology 2021-09, Vol.178 (17), p.3373-3394
Hauptverfasser:	Jain, Pritesh P., Zhao, Tengteng, Xiong, Mingmei, Song, Shanshan, Lai, Ning, Zheng, Qiuyu, Chen, Jiyuan, Carr, Shane G., Babicheva, Aleksandra, Izadi, Amin, Rodriguez, Marisela, Rahimi, Shamin, Balistrieri, Francesca, Rahimi, Shayan, Simonson, Tatum, Valdez‐Jasso, Daniela, Thistlethwaite, Patricia A., Shyy, John Y.‐J., Wang, Jian, Makino, Ayako, Yuan, Jason X.‐J.
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Alveoli Animals Ca2+ channel Calcium Calcium (intracellular) Calcium channels Calcium channels (voltage-gated) Calcium influx Contraction Fluorescence microscopy halofuginone Hypertension Hypertension, Pulmonary - drug therapy Hypoxia Hypoxia - drug therapy K+ channel KCNA5 Mice Myocytes, Smooth Muscle Nitric oxide Pharmaceutical Preparations Phosphatidylinositol 3-Kinases Piperidines Potassium Potassium channels (voltage-gated) Potassium currents Pulmonary arterial hypertension Pulmonary arteries Pulmonary Artery Pulmonary hypertension Quinazolinones Signal transduction Smooth muscle smooth muscle cell TOR protein treatment Vasoconstriction Vasodilation
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