Acinar cell carcinoma with PRKAR1A and PTEN alterations and paraneoplastic panniculitis
Pancreatic acinar cell carcinoma is a rare type of pancreatic malignancy, which can be confused with pancreatic neuroendocrine neoplasm. Here, we describe a woman in her 80s who presented with abdominal pain and bilateral lower extremity panniculitis. She underwent surgery for a presumed diagnosis o...
Gespeichert in:
| Veröffentlicht in: | BMJ case reports 2022-12, Vol.15 (12), p.e251400 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 12 |
| container_start_page | e251400 |
| container_title | BMJ case reports |
| container_volume | 15 |
| creator | Yang, Zhizhou Zarate Rodriguez, Jorge G Beck, Haley Byrnes, Kathleen Trikalinos, Nikolaos A Hammill, Chet W |
| description | Pancreatic acinar cell carcinoma is a rare type of pancreatic malignancy, which can be confused with pancreatic neuroendocrine neoplasm. Here, we describe a woman in her 80s who presented with abdominal pain and bilateral lower extremity panniculitis. She underwent surgery for a presumed diagnosis of neuroendocrine tumour with PTEN and PRKAR1A alterations; 19 months, later, a recurrence of her pancreatic malignancy was discovered. The patient underwent repeat resection and this time immunohistochemical staining confirmed the diagnosis of acinar cell carcinoma. Staining for acinar cell carcinoma should be prompted based on clinical suspicion in context of PTEN or PRKAR1A mutation when appropriate. |
| doi_str_mv | 10.1136/bcr-2022-251400 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9791417</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2758101462</sourcerecordid><originalsourceid>FETCH-LOGICAL-c334t-6a58556d88a32d8654956ebf9cbdd2d37550a35a3f6ce203b5a787263c34931c3</originalsourceid><addsrcrecordid>eNpdkc9LwzAUx4MoKtOzNyl48VKX5DVNexGGzB84VGSit_CaZhrp0pm0iv-9rZsyzSV5yed9ed98CTlg9IQxSIeF9jGnnMdcsITSDbLLpJCxzOnT5tp5h-yH8Eq7BSzJEtgmO5CKJJcCdsnjSFuHPtKmqiKNvqvqOUYftnmJ7u6vR_dsFKEro7vp-CbCqjEeG1u78H25QI_O1IsKQ2N1VzpndVvZxoY9sjXDKpj91T4gD-fj6dllPLm9uDobTWINkDRxiiITIi2zDIGXWT-WSE0xy3VRlrwEKQRFEAizVBtOoRAoM8lT0JDkwDQMyOlSd9EWc1Nq4xqPlVp4O0f_qWq06u-Lsy_quX5XucxZwmQncLwS8PVba0Kj5jb0v9E7a4PiUmSMsiTlHXr0D32tW-86ez0lGQgGveBwSWlfh-DN7HcYRlWfm-pyU31uaplb13G47uGX_0kJvgAk0ZMb</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2757135137</pqid></control><display><type>article</type><title>Acinar cell carcinoma with PRKAR1A and PTEN alterations and paraneoplastic panniculitis</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Yang, Zhizhou ; Zarate Rodriguez, Jorge G ; Beck, Haley ; Byrnes, Kathleen ; Trikalinos, Nikolaos A ; Hammill, Chet W</creator><creatorcontrib>Yang, Zhizhou ; Zarate Rodriguez, Jorge G ; Beck, Haley ; Byrnes, Kathleen ; Trikalinos, Nikolaos A ; Hammill, Chet W</creatorcontrib><description>Pancreatic acinar cell carcinoma is a rare type of pancreatic malignancy, which can be confused with pancreatic neuroendocrine neoplasm. Here, we describe a woman in her 80s who presented with abdominal pain and bilateral lower extremity panniculitis. She underwent surgery for a presumed diagnosis of neuroendocrine tumour with PTEN and PRKAR1A alterations; 19 months, later, a recurrence of her pancreatic malignancy was discovered. The patient underwent repeat resection and this time immunohistochemical staining confirmed the diagnosis of acinar cell carcinoma. Staining for acinar cell carcinoma should be prompted based on clinical suspicion in context of PTEN or PRKAR1A mutation when appropriate.</description><identifier>ISSN: 1757-790X</identifier><identifier>EISSN: 1757-790X</identifier><identifier>DOI: 10.1136/bcr-2022-251400</identifier><identifier>PMID: 36549753</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Abdomen ; Cancer ; Carcinoma, Acinar Cell - complications ; Carcinoma, Acinar Cell - diagnosis ; Carcinoma, Acinar Cell - surgery ; Case reports ; Case Reports: Reminder of important clinical lesson ; Chemotherapy ; Cyclic AMP-Dependent Protein Kinase RIalpha Subunit ; Diagnosis, Differential ; Disease ; Female ; Histology ; Humans ; Medical imaging ; Morphology ; Mutation ; Neuroendocrine tumors ; Neuroendocrine Tumors - diagnosis ; Pancreatic cancer ; Pancreatic Neoplasms - pathology ; Panniculitis - diagnosis ; Panniculitis - etiology ; Panniculitis - pathology ; Pathology ; PTEN Phosphohydrolase - genetics ; Stains & staining</subject><ispartof>BMJ case reports, 2022-12, Vol.15 (12), p.e251400</ispartof><rights>BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2022 BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>BMJ Publishing Group Limited 2022. No commercial re-use. See rights and permissions. Published by BMJ. 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c334t-6a58556d88a32d8654956ebf9cbdd2d37550a35a3f6ce203b5a787263c34931c3</cites><orcidid>0000-0002-0921-3606</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791417/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9791417/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36549753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Zhizhou</creatorcontrib><creatorcontrib>Zarate Rodriguez, Jorge G</creatorcontrib><creatorcontrib>Beck, Haley</creatorcontrib><creatorcontrib>Byrnes, Kathleen</creatorcontrib><creatorcontrib>Trikalinos, Nikolaos A</creatorcontrib><creatorcontrib>Hammill, Chet W</creatorcontrib><title>Acinar cell carcinoma with PRKAR1A and PTEN alterations and paraneoplastic panniculitis</title><title>BMJ case reports</title><addtitle>BMJ Case Rep</addtitle><description>Pancreatic acinar cell carcinoma is a rare type of pancreatic malignancy, which can be confused with pancreatic neuroendocrine neoplasm. Here, we describe a woman in her 80s who presented with abdominal pain and bilateral lower extremity panniculitis. She underwent surgery for a presumed diagnosis of neuroendocrine tumour with PTEN and PRKAR1A alterations; 19 months, later, a recurrence of her pancreatic malignancy was discovered. The patient underwent repeat resection and this time immunohistochemical staining confirmed the diagnosis of acinar cell carcinoma. Staining for acinar cell carcinoma should be prompted based on clinical suspicion in context of PTEN or PRKAR1A mutation when appropriate.</description><subject>Abdomen</subject><subject>Cancer</subject><subject>Carcinoma, Acinar Cell - complications</subject><subject>Carcinoma, Acinar Cell - diagnosis</subject><subject>Carcinoma, Acinar Cell - surgery</subject><subject>Case reports</subject><subject>Case Reports: Reminder of important clinical lesson</subject><subject>Chemotherapy</subject><subject>Cyclic AMP-Dependent Protein Kinase RIalpha Subunit</subject><subject>Diagnosis, Differential</subject><subject>Disease</subject><subject>Female</subject><subject>Histology</subject><subject>Humans</subject><subject>Medical imaging</subject><subject>Morphology</subject><subject>Mutation</subject><subject>Neuroendocrine tumors</subject><subject>Neuroendocrine Tumors - diagnosis</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Panniculitis - diagnosis</subject><subject>Panniculitis - etiology</subject><subject>Panniculitis - pathology</subject><subject>Pathology</subject><subject>PTEN Phosphohydrolase - genetics</subject><subject>Stains & staining</subject><issn>1757-790X</issn><issn>1757-790X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkc9LwzAUx4MoKtOzNyl48VKX5DVNexGGzB84VGSit_CaZhrp0pm0iv-9rZsyzSV5yed9ed98CTlg9IQxSIeF9jGnnMdcsITSDbLLpJCxzOnT5tp5h-yH8Eq7BSzJEtgmO5CKJJcCdsnjSFuHPtKmqiKNvqvqOUYftnmJ7u6vR_dsFKEro7vp-CbCqjEeG1u78H25QI_O1IsKQ2N1VzpndVvZxoY9sjXDKpj91T4gD-fj6dllPLm9uDobTWINkDRxiiITIi2zDIGXWT-WSE0xy3VRlrwEKQRFEAizVBtOoRAoM8lT0JDkwDQMyOlSd9EWc1Nq4xqPlVp4O0f_qWq06u-Lsy_quX5XucxZwmQncLwS8PVba0Kj5jb0v9E7a4PiUmSMsiTlHXr0D32tW-86ez0lGQgGveBwSWlfh-DN7HcYRlWfm-pyU31uaplb13G47uGX_0kJvgAk0ZMb</recordid><startdate>20221222</startdate><enddate>20221222</enddate><creator>Yang, Zhizhou</creator><creator>Zarate Rodriguez, Jorge G</creator><creator>Beck, Haley</creator><creator>Byrnes, Kathleen</creator><creator>Trikalinos, Nikolaos A</creator><creator>Hammill, Chet W</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0921-3606</orcidid></search><sort><creationdate>20221222</creationdate><title>Acinar cell carcinoma with PRKAR1A and PTEN alterations and paraneoplastic panniculitis</title><author>Yang, Zhizhou ; Zarate Rodriguez, Jorge G ; Beck, Haley ; Byrnes, Kathleen ; Trikalinos, Nikolaos A ; Hammill, Chet W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-6a58556d88a32d8654956ebf9cbdd2d37550a35a3f6ce203b5a787263c34931c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abdomen</topic><topic>Cancer</topic><topic>Carcinoma, Acinar Cell - complications</topic><topic>Carcinoma, Acinar Cell - diagnosis</topic><topic>Carcinoma, Acinar Cell - surgery</topic><topic>Case reports</topic><topic>Case Reports: Reminder of important clinical lesson</topic><topic>Chemotherapy</topic><topic>Cyclic AMP-Dependent Protein Kinase RIalpha Subunit</topic><topic>Diagnosis, Differential</topic><topic>Disease</topic><topic>Female</topic><topic>Histology</topic><topic>Humans</topic><topic>Medical imaging</topic><topic>Morphology</topic><topic>Mutation</topic><topic>Neuroendocrine tumors</topic><topic>Neuroendocrine Tumors - diagnosis</topic><topic>Pancreatic cancer</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Panniculitis - diagnosis</topic><topic>Panniculitis - etiology</topic><topic>Panniculitis - pathology</topic><topic>Pathology</topic><topic>PTEN Phosphohydrolase - genetics</topic><topic>Stains & staining</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Zhizhou</creatorcontrib><creatorcontrib>Zarate Rodriguez, Jorge G</creatorcontrib><creatorcontrib>Beck, Haley</creatorcontrib><creatorcontrib>Byrnes, Kathleen</creatorcontrib><creatorcontrib>Trikalinos, Nikolaos A</creatorcontrib><creatorcontrib>Hammill, Chet W</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ case reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Zhizhou</au><au>Zarate Rodriguez, Jorge G</au><au>Beck, Haley</au><au>Byrnes, Kathleen</au><au>Trikalinos, Nikolaos A</au><au>Hammill, Chet W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acinar cell carcinoma with PRKAR1A and PTEN alterations and paraneoplastic panniculitis</atitle><jtitle>BMJ case reports</jtitle><addtitle>BMJ Case Rep</addtitle><date>2022-12-22</date><risdate>2022</risdate><volume>15</volume><issue>12</issue><spage>e251400</spage><pages>e251400-</pages><issn>1757-790X</issn><eissn>1757-790X</eissn><abstract>Pancreatic acinar cell carcinoma is a rare type of pancreatic malignancy, which can be confused with pancreatic neuroendocrine neoplasm. Here, we describe a woman in her 80s who presented with abdominal pain and bilateral lower extremity panniculitis. She underwent surgery for a presumed diagnosis of neuroendocrine tumour with PTEN and PRKAR1A alterations; 19 months, later, a recurrence of her pancreatic malignancy was discovered. The patient underwent repeat resection and this time immunohistochemical staining confirmed the diagnosis of acinar cell carcinoma. Staining for acinar cell carcinoma should be prompted based on clinical suspicion in context of PTEN or PRKAR1A mutation when appropriate.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>36549753</pmid><doi>10.1136/bcr-2022-251400</doi><orcidid>https://orcid.org/0000-0002-0921-3606</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1757-790X |
| ispartof | BMJ case reports, 2022-12, Vol.15 (12), p.e251400 |
| issn | 1757-790X 1757-790X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9791417 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Abdomen Cancer Carcinoma, Acinar Cell - complications Carcinoma, Acinar Cell - diagnosis Carcinoma, Acinar Cell - surgery Case reports Case Reports: Reminder of important clinical lesson Chemotherapy Cyclic AMP-Dependent Protein Kinase RIalpha Subunit Diagnosis, Differential Disease Female Histology Humans Medical imaging Morphology Mutation Neuroendocrine tumors Neuroendocrine Tumors - diagnosis Pancreatic cancer Pancreatic Neoplasms - pathology Panniculitis - diagnosis Panniculitis - etiology Panniculitis - pathology Pathology PTEN Phosphohydrolase - genetics Stains & staining |
| title | Acinar cell carcinoma with PRKAR1A and PTEN alterations and paraneoplastic panniculitis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T15%3A13%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acinar%20cell%20carcinoma%20with%20PRKAR1A%20and%20PTEN%20alterations%20and%20paraneoplastic%20panniculitis&rft.jtitle=BMJ%20case%20reports&rft.au=Yang,%20Zhizhou&rft.date=2022-12-22&rft.volume=15&rft.issue=12&rft.spage=e251400&rft.pages=e251400-&rft.issn=1757-790X&rft.eissn=1757-790X&rft_id=info:doi/10.1136/bcr-2022-251400&rft_dat=%3Cproquest_pubme%3E2758101462%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2757135137&rft_id=info:pmid/36549753&rfr_iscdi=true |