Prostaglandin EP3 receptor-expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling

The bidirectional controller of the thermoregulatory center in the preoptic area (POA) is unknown. Using rats, here, we identify prostaglandin EP3 receptor-expressing POA neurons (POA neurons) as a pivotal bidirectional controller in the central thermoregulatory mechanism. POA neurons are activated...

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Veröffentlicht in:	Science advances 2022-12, Vol.8 (51), p.eadd5463-eadd5463
Hauptverfasser:	Nakamura, Yoshiko, Yahiro, Takaki, Fukushima, Akihiro, Kataoka, Naoya, Hioki, Hiroyuki, Nakamura, Kazuhiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Temperature Body Temperature Regulation - physiology Fever Neurons - physiology Neuroscience Physiology Prostaglandins Rats Receptors, Prostaglandin Receptors, Prostaglandin E, EP3 Subtype SciAdv r-articles
Online-Zugang:	Volltext
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