The Polyunsaturated Fatty Acid EPA, but Not DHA, Enhances Neurotrophic Factor Expression through Epigenetic Mechanisms and Protects against Parkinsonian Neuronal Cell Death

ω-3 Polyunsaturated fatty acids (PUFAs) have been found to exert many actions, including neuroprotective effects. In this regard, the exact molecular mechanisms are not well understood. Parkinson's disease (PD) is the second most common age-related neurodegenerative disease. Emerging evidence s...

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Veröffentlicht in:	International journal of molecular sciences 2022-12, Vol.23 (24), p.16176
Hauptverfasser:	Ceccarini, Maria Rachele, Ceccarelli, Veronica, Codini, Michela, Fettucciari, Katia, Calvitti, Mario, Cataldi, Samuela, Albi, Elisabetta, Vecchini, Alba, Beccari, Tommaso
Format:	Artikel
Sprache:	eng
Schlagworte:	6-Hydroxydopamine Abnormalities Alzheimer's disease Apoptosis Basal ganglia Brain Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - pharmacology Cancer Cell death Central nervous system diseases Cytology Cytotoxicity Deoxyribonucleic acid Diabetic neuropathy DNA DNA methylation Docosahexaenoic acid Docosahexaenoic Acids - pharmacology Dopamine Eicosapentaenoic acid Eicosapentaenoic Acid - pharmacology Epigenesis, Genetic Epigenetics Fatty acids Fatty Acids, Unsaturated - pharmacology Flow cytometry Gene expression Glial Cell Line-Derived Neurotrophic Factor - genetics Glial Cell Line-Derived Neurotrophic Factor - pharmacology Glial cells Humans Mitochondria Molecular modelling mRNA Neuroblastoma Neurodegeneration Neurodegenerative Diseases Neuronal-glial interactions Neurons Oxidative stress Parkinson Disease - genetics Parkinson's disease Polyunsaturated fatty acids Signal transduction Synaptogenesis Toxins Transmission electron microscopy Ultrastructure
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