mTOR Signaling Network in Cell Biology and Human Disease
The mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that regulates multiple processes, including gene transcription, protein synthesis, ribosome biogenesis, autophagy, cell metabolism, and cell growth [...].
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2022-12, Vol.23 (24), p.16142 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 24 |
| container_start_page | 16142 |
| container_title | International journal of molecular sciences |
| container_volume | 23 |
| creator | Yu, Jane J Goncharova, Elena A |
| description | The mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that regulates multiple processes, including gene transcription, protein synthesis, ribosome biogenesis, autophagy, cell metabolism, and cell growth [...]. |
| doi_str_mv | 10.3390/ijms232416142 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9787689</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2756739311</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-316dfea29e68ef0b5e10947258b58308d38b22386e33afc0c3ba64abf8b5bf743</originalsourceid><addsrcrecordid>eNpdkctLw0AQxhdRbK0evUrAi5foPrKPXAStjwrFgtbzskk2cWuyW7OJ0v_e1NbSepkZmB8f880HwCmCl4TE8MrMKo8JjhBDEd4D_a7iEELG97fmHjjyfgZhB9L4EPQIo5RyQfpAVNPJS_BqCqtKY4vgWTffrv4IjA2GuiyDW-NKVywCZbNg1FbKBnfGa-X1MTjIVen1yboPwNvD_XQ4CseTx6fhzThMI0SbkCCW5VrhWDOhc5hQjWAccUxFQgWBIiMiwZgIpglReQpTkigWqSTv9knOIzIA1yvdeZtUOku1bWpVynltKlUvpFNG7m6seZeF-5IxF5yJuBO4WAvU7rPVvpGV8WnnTVntWi8xpwJBEbElev4Pnbm27j7zSzFOYoJQR4UrKq2d97XON8cgKJeZyJ1MOv5s28GG_guB_ADFE4aq</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2756739311</pqid></control><display><type>article</type><title>mTOR Signaling Network in Cell Biology and Human Disease</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Yu, Jane J ; Goncharova, Elena A</creator><creatorcontrib>Yu, Jane J ; Goncharova, Elena A</creatorcontrib><description>The mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that regulates multiple processes, including gene transcription, protein synthesis, ribosome biogenesis, autophagy, cell metabolism, and cell growth [...].</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms232416142</identifier><identifier>PMID: 36555783</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Autism ; Autophagy ; Brain ; Cancer ; Cell growth ; Cyclin-dependent kinases ; Disease ; Genes ; Humans ; Kinases ; Lungs ; Mechanistic Target of Rapamycin Complex 1 - metabolism ; Medical prognosis ; Melanoma ; Metastasis ; Mutation ; Protein Biosynthesis ; Protein synthesis ; Proteins ; Signal Transduction - genetics ; TOR protein ; TOR Serine-Threonine Kinases - metabolism ; Tumors</subject><ispartof>International journal of molecular sciences, 2022-12, Vol.23 (24), p.16142</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-316dfea29e68ef0b5e10947258b58308d38b22386e33afc0c3ba64abf8b5bf743</citedby><cites>FETCH-LOGICAL-c415t-316dfea29e68ef0b5e10947258b58308d38b22386e33afc0c3ba64abf8b5bf743</cites><orcidid>0000-0001-7118-6752</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787689/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9787689/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36555783$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Jane J</creatorcontrib><creatorcontrib>Goncharova, Elena A</creatorcontrib><title>mTOR Signaling Network in Cell Biology and Human Disease</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>The mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that regulates multiple processes, including gene transcription, protein synthesis, ribosome biogenesis, autophagy, cell metabolism, and cell growth [...].</description><subject>Autism</subject><subject>Autophagy</subject><subject>Brain</subject><subject>Cancer</subject><subject>Cell growth</subject><subject>Cyclin-dependent kinases</subject><subject>Disease</subject><subject>Genes</subject><subject>Humans</subject><subject>Kinases</subject><subject>Lungs</subject><subject>Mechanistic Target of Rapamycin Complex 1 - metabolism</subject><subject>Medical prognosis</subject><subject>Melanoma</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>Protein Biosynthesis</subject><subject>Protein synthesis</subject><subject>Proteins</subject><subject>Signal Transduction - genetics</subject><subject>TOR protein</subject><subject>TOR Serine-Threonine Kinases - metabolism</subject><subject>Tumors</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkctLw0AQxhdRbK0evUrAi5foPrKPXAStjwrFgtbzskk2cWuyW7OJ0v_e1NbSepkZmB8f880HwCmCl4TE8MrMKo8JjhBDEd4D_a7iEELG97fmHjjyfgZhB9L4EPQIo5RyQfpAVNPJS_BqCqtKY4vgWTffrv4IjA2GuiyDW-NKVywCZbNg1FbKBnfGa-X1MTjIVen1yboPwNvD_XQ4CseTx6fhzThMI0SbkCCW5VrhWDOhc5hQjWAccUxFQgWBIiMiwZgIpglReQpTkigWqSTv9knOIzIA1yvdeZtUOku1bWpVynltKlUvpFNG7m6seZeF-5IxF5yJuBO4WAvU7rPVvpGV8WnnTVntWi8xpwJBEbElev4Pnbm27j7zSzFOYoJQR4UrKq2d97XON8cgKJeZyJ1MOv5s28GG_guB_ADFE4aq</recordid><startdate>20221218</startdate><enddate>20221218</enddate><creator>Yu, Jane J</creator><creator>Goncharova, Elena A</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7118-6752</orcidid></search><sort><creationdate>20221218</creationdate><title>mTOR Signaling Network in Cell Biology and Human Disease</title><author>Yu, Jane J ; Goncharova, Elena A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-316dfea29e68ef0b5e10947258b58308d38b22386e33afc0c3ba64abf8b5bf743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Autism</topic><topic>Autophagy</topic><topic>Brain</topic><topic>Cancer</topic><topic>Cell growth</topic><topic>Cyclin-dependent kinases</topic><topic>Disease</topic><topic>Genes</topic><topic>Humans</topic><topic>Kinases</topic><topic>Lungs</topic><topic>Mechanistic Target of Rapamycin Complex 1 - metabolism</topic><topic>Medical prognosis</topic><topic>Melanoma</topic><topic>Metastasis</topic><topic>Mutation</topic><topic>Protein Biosynthesis</topic><topic>Protein synthesis</topic><topic>Proteins</topic><topic>Signal Transduction - genetics</topic><topic>TOR protein</topic><topic>TOR Serine-Threonine Kinases - metabolism</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Jane J</creatorcontrib><creatorcontrib>Goncharova, Elena A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Jane J</au><au>Goncharova, Elena A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>mTOR Signaling Network in Cell Biology and Human Disease</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2022-12-18</date><risdate>2022</risdate><volume>23</volume><issue>24</issue><spage>16142</spage><pages>16142-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>The mechanistic target of rapamycin (mTOR) is a serine/threonine protein kinase that regulates multiple processes, including gene transcription, protein synthesis, ribosome biogenesis, autophagy, cell metabolism, and cell growth [...].</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36555783</pmid><doi>10.3390/ijms232416142</doi><orcidid>https://orcid.org/0000-0001-7118-6752</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2022-12, Vol.23 (24), p.16142 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9787689 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Autism Autophagy Brain Cancer Cell growth Cyclin-dependent kinases Disease Genes Humans Kinases Lungs Mechanistic Target of Rapamycin Complex 1 - metabolism Medical prognosis Melanoma Metastasis Mutation Protein Biosynthesis Protein synthesis Proteins Signal Transduction - genetics TOR protein TOR Serine-Threonine Kinases - metabolism Tumors |
| title | mTOR Signaling Network in Cell Biology and Human Disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-04T10%3A37%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=mTOR%20Signaling%20Network%20in%20Cell%20Biology%20and%20Human%20Disease&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Yu,%20Jane%20J&rft.date=2022-12-18&rft.volume=23&rft.issue=24&rft.spage=16142&rft.pages=16142-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms232416142&rft_dat=%3Cproquest_pubme%3E2756739311%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2756739311&rft_id=info:pmid/36555783&rfr_iscdi=true |