Yeast β‐Glucan Improves Insulin Sensitivity and Hepatic Lipid Metabolism in Mice Humanized with Obese Type 2 Diabetic Gut Microbiota

Scope Gut microbiota alterations are associated with obesity and type 2 diabetes. Yeast β‐glucans are potential modulators of the innate immune‐metabolic response, by impacting glucose, lipid, and cholesterol homeostasis. The study examines whether yeast β‐glucan interacts differentially with either...

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Veröffentlicht in:	Molecular nutrition & food research 2022-11, Vol.66 (22), p.e2100819-n/a
Hauptverfasser:	Mitchelson, Kathleen A. J., Tran, Tam T. T., Dillon, Eugene T., Vlckova, Klara, Harrison, Sabine M., Ntemiri, Alexandra, Cunningham, Katie, Gibson, Irene, Finucane, Francis M., O'Connor, Eibhlís M., Roche, Helen M., O'Toole, Paul W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Glucans - pharmacology Cholesterol Colonization Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 Diet Diet, High-Fat - adverse effects Gastrointestinal Microbiome Glucan Glucans gut microbiota hepatic triacylglycerol (TAG) High fat diet Homeostasis Insulin Insulin Resistance Intestinal microflora Lipid metabolism Lipid Metabolism - genetics Lipids Liver Male Metabolic response Metabolism Mice Mice, Inbred C57BL Mice, Obese Microbiomes Microbiota Mitochondria Modulators Obesity Obesity - metabolism Oxidative phosphorylation Phenotypes Phosphorylation Protein biosynthesis Protein synthesis Proteomics Saccharomyces cerevisiae Transplantation type 2 diabetes Yeast yeast β‐glucan Yeasts β-Glucan
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