Synthesis of Hollow Calcium Carbonate Microspheres by a Template Method for DOX Loading and Release with Carbon Dots Photosensitivity
Calcium carbonate, as the main inorganic component of human bones and teeth, has good biocompatibility and bioactivity and finds increasing applications in the field of bone drug carriers. In this study, hollow calcium carbonate microspheres were synthesized by a water hydrothermal method using foli...
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| Veröffentlicht in: | Materials 2022-12, Vol.15 (24), p.8768 |
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| description | Calcium carbonate, as the main inorganic component of human bones and teeth, has good biocompatibility and bioactivity and finds increasing applications in the field of bone drug carriers. In this study, hollow calcium carbonate microspheres were synthesized by a water hydrothermal method using folic acid as a template. Before drug loading, the prepared calcium carbonate microspheres were subjected to aminidation, carboxylation, and vinylenimine modification. The hollow calcium carbonate microspheres loaded with doxorubicin hydrochloride (DOX) were further incorporated with light-emitting carbon quantum dots(CQDs) and hyaluronic acid (HA). The result showed that the drug loading capacity in the as-prepared calcium carbonate was 179.064 mg/g. In the simulated solutions of cellular metabolism containing various concentrations of reduced glutathione(GSH), the sustained release of DOX was confirmed qualitatively by the luminescence of the CQDs. The DOX release rate was measured quantitively by UV absorption spectra. The highest release rate reached 85.99% in a simulated solution of 0.005 mol/L GSH solution, and the release rate could vary intelligently with the concentration. |
| doi_str_mv | 10.3390/ma15248768 |
| format | Article |
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In this study, hollow calcium carbonate microspheres were synthesized by a water hydrothermal method using folic acid as a template. Before drug loading, the prepared calcium carbonate microspheres were subjected to aminidation, carboxylation, and vinylenimine modification. The hollow calcium carbonate microspheres loaded with doxorubicin hydrochloride (DOX) were further incorporated with light-emitting carbon quantum dots(CQDs) and hyaluronic acid (HA). The result showed that the drug loading capacity in the as-prepared calcium carbonate was 179.064 mg/g. In the simulated solutions of cellular metabolism containing various concentrations of reduced glutathione(GSH), the sustained release of DOX was confirmed qualitatively by the luminescence of the CQDs. The DOX release rate was measured quantitively by UV absorption spectra. The highest release rate reached 85.99% in a simulated solution of 0.005 mol/L GSH solution, and the release rate could vary intelligently with the concentration.</description><identifier>ISSN: 1996-1944</identifier><identifier>EISSN: 1996-1944</identifier><identifier>DOI: 10.3390/ma15248768</identifier><identifier>PMID: 36556578</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Absorption spectra ; Biocompatibility ; Bones ; Calcium carbonate ; Carbon ; Carbon dots ; Carboxylation ; Crystal structure ; Doxorubicin ; Drug carriers ; Drug delivery systems ; Drugs ; Folic acid ; Glutathione ; Graphene ; Hyaluronic acid ; Hydroxyapatite ; Methods ; Microspheres ; Photosensitivity ; Product introduction ; Quantum dots ; Sustained release ; Vehicles</subject><ispartof>Materials, 2022-12, Vol.15 (24), p.8768</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c473t-eb14e38221ca3480cf70dadad55d5cce0fa5a592370d3233763d066a7d218fd23</citedby><cites>FETCH-LOGICAL-c473t-eb14e38221ca3480cf70dadad55d5cce0fa5a592370d3233763d066a7d218fd23</cites><orcidid>0000-0002-7328-7706</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786317/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9786317/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36556578$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mo, Fuwang</creatorcontrib><creatorcontrib>Chen, Qiujuan</creatorcontrib><creatorcontrib>Zhang, Xiaohui</creatorcontrib><title>Synthesis of Hollow Calcium Carbonate Microspheres by a Template Method for DOX Loading and Release with Carbon Dots Photosensitivity</title><title>Materials</title><addtitle>Materials (Basel)</addtitle><description>Calcium carbonate, as the main inorganic component of human bones and teeth, has good biocompatibility and bioactivity and finds increasing applications in the field of bone drug carriers. In this study, hollow calcium carbonate microspheres were synthesized by a water hydrothermal method using folic acid as a template. Before drug loading, the prepared calcium carbonate microspheres were subjected to aminidation, carboxylation, and vinylenimine modification. The hollow calcium carbonate microspheres loaded with doxorubicin hydrochloride (DOX) were further incorporated with light-emitting carbon quantum dots(CQDs) and hyaluronic acid (HA). The result showed that the drug loading capacity in the as-prepared calcium carbonate was 179.064 mg/g. In the simulated solutions of cellular metabolism containing various concentrations of reduced glutathione(GSH), the sustained release of DOX was confirmed qualitatively by the luminescence of the CQDs. The DOX release rate was measured quantitively by UV absorption spectra. The highest release rate reached 85.99% in a simulated solution of 0.005 mol/L GSH solution, and the release rate could vary intelligently with the concentration.</description><subject>Absorption spectra</subject><subject>Biocompatibility</subject><subject>Bones</subject><subject>Calcium carbonate</subject><subject>Carbon</subject><subject>Carbon dots</subject><subject>Carboxylation</subject><subject>Crystal structure</subject><subject>Doxorubicin</subject><subject>Drug carriers</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Folic acid</subject><subject>Glutathione</subject><subject>Graphene</subject><subject>Hyaluronic acid</subject><subject>Hydroxyapatite</subject><subject>Methods</subject><subject>Microspheres</subject><subject>Photosensitivity</subject><subject>Product introduction</subject><subject>Quantum dots</subject><subject>Sustained release</subject><subject>Vehicles</subject><issn>1996-1944</issn><issn>1996-1944</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptklFrFDEQxxdRbKl98QNIwBcRrm6STbL7IpSrWuGkohV8C7lk9jYlm5xJtuU-QL93c_asVzHzMGHmN_9hkqmql7g-obSr340KM9K0grdPqkPcdXyGu6Z5unc_qI5TuqrLoRS3pHteHVDOGGeiPaxuv298HiDZhEKPzoNz4QbNldN2GouPy-BVBvTF6hjSeoAICS03SKFLGNfudwryEAzqQ0RnFz_RIihj_Qopb9A3cKASoBubh50YOgs5oa9DyCGBTzbba5s3L6pnvXIJjnf-qPrx8cPl_Hy2uPj0eX66mOlG0DyDJW6AtoRgrWjT1roXtVHFGDNMa6h7xRTrCC1hSigVnJqacyUMwW1vCD2q3t_rrqflCEaDz1E5uY52VHEjg7LyccbbQa7CtexEyykWReDNTiCGXxOkLEebNDinPIQpSSJYi2vBeVPQ1_-gV2GKvoy3pbjgXSf2qJVyIK3vQ-mrt6LyVDRMNKT0LdTJf6hiBkarg4felvijgrf3BdtvSxH6hxlxLbd7I__uTYFf7b_KA_pnS-gdxHq9pQ</recordid><startdate>20221208</startdate><enddate>20221208</enddate><creator>Mo, Fuwang</creator><creator>Chen, Qiujuan</creator><creator>Zhang, Xiaohui</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7328-7706</orcidid></search><sort><creationdate>20221208</creationdate><title>Synthesis of Hollow Calcium Carbonate Microspheres by a Template Method for DOX Loading and Release with Carbon Dots Photosensitivity</title><author>Mo, Fuwang ; Chen, Qiujuan ; Zhang, Xiaohui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c473t-eb14e38221ca3480cf70dadad55d5cce0fa5a592370d3233763d066a7d218fd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Absorption spectra</topic><topic>Biocompatibility</topic><topic>Bones</topic><topic>Calcium carbonate</topic><topic>Carbon</topic><topic>Carbon dots</topic><topic>Carboxylation</topic><topic>Crystal structure</topic><topic>Doxorubicin</topic><topic>Drug carriers</topic><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>Folic acid</topic><topic>Glutathione</topic><topic>Graphene</topic><topic>Hyaluronic acid</topic><topic>Hydroxyapatite</topic><topic>Methods</topic><topic>Microspheres</topic><topic>Photosensitivity</topic><topic>Product introduction</topic><topic>Quantum dots</topic><topic>Sustained release</topic><topic>Vehicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mo, Fuwang</creatorcontrib><creatorcontrib>Chen, Qiujuan</creatorcontrib><creatorcontrib>Zhang, Xiaohui</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials science collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mo, Fuwang</au><au>Chen, Qiujuan</au><au>Zhang, Xiaohui</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis of Hollow Calcium Carbonate Microspheres by a Template Method for DOX Loading and Release with Carbon Dots Photosensitivity</atitle><jtitle>Materials</jtitle><addtitle>Materials (Basel)</addtitle><date>2022-12-08</date><risdate>2022</risdate><volume>15</volume><issue>24</issue><spage>8768</spage><pages>8768-</pages><issn>1996-1944</issn><eissn>1996-1944</eissn><abstract>Calcium carbonate, as the main inorganic component of human bones and teeth, has good biocompatibility and bioactivity and finds increasing applications in the field of bone drug carriers. In this study, hollow calcium carbonate microspheres were synthesized by a water hydrothermal method using folic acid as a template. Before drug loading, the prepared calcium carbonate microspheres were subjected to aminidation, carboxylation, and vinylenimine modification. The hollow calcium carbonate microspheres loaded with doxorubicin hydrochloride (DOX) were further incorporated with light-emitting carbon quantum dots(CQDs) and hyaluronic acid (HA). The result showed that the drug loading capacity in the as-prepared calcium carbonate was 179.064 mg/g. In the simulated solutions of cellular metabolism containing various concentrations of reduced glutathione(GSH), the sustained release of DOX was confirmed qualitatively by the luminescence of the CQDs. The DOX release rate was measured quantitively by UV absorption spectra. 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| source | MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; PubMed Central Open Access |
| subjects | Absorption spectra Biocompatibility Bones Calcium carbonate Carbon Carbon dots Carboxylation Crystal structure Doxorubicin Drug carriers Drug delivery systems Drugs Folic acid Glutathione Graphene Hyaluronic acid Hydroxyapatite Methods Microspheres Photosensitivity Product introduction Quantum dots Sustained release Vehicles |
| title | Synthesis of Hollow Calcium Carbonate Microspheres by a Template Method for DOX Loading and Release with Carbon Dots Photosensitivity |
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