HCV-HIV Chronic Coinfection Prevalence in Amazon Region
Hepatitis C virus (HCV) infection is an important public health problem, especially in areas with a low human development index such as the Amazon region. This study aimed to identify the prevalence and genotypes of HCV among people living with HIV (PLWH), both neglected chronic diseases in the Amaz...
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| Veröffentlicht in: | Journal of clinical medicine 2022-12, Vol.11 (24), p.7284 |
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| creator | Lobo, Marcio Nahum Irias, Susan Denice Flores Neto, Pedro Leão Fontes Avelino, Maria Eduarda Sousa da Silva Torres, Maria Karoliny de Carvalho Souza, Marlinda Fonseca, Ricardo Roberto Souza Freitas, Pedro Eduardo Bonfim Nunes, Heloisa Marceliano de Araújo Júnior, José Raul Rocha de Brito, Dickson Ciro Nascimento Oliveira-Filho, Aldemir Branco Machado, Luiz Fernando Almeida |
| description | Hepatitis C virus (HCV) infection is an important public health problem, especially in areas with a low human development index such as the Amazon region. This study aimed to identify the prevalence and genotypes of HCV among people living with HIV (PLWH), both neglected chronic diseases in the Amazon region. From March 2016 to June 2017, 433 PWLH were attended to at two sexually transmitted infection referral centers in the city of Belém, in the Brazilian state of Pará in the Amazon region. All individuals were submitted to testing via the rapid immunochromatographic assay (RIA) for the qualitative detection of anti-HCV antibodies. Samples with anti-HCV antibodies were evaluated by reverse transcriptase polymerase chain reaction (RT-PCR), and samples with HCV RNA were subjected to nucleotide sequencing and phylogenetic analysis. Three (0.7%) PLWH had anti-HCV antibodies, and only one (0.2%) had HCV RNA (genotype 2); of these, 31 (7.1%) self-declared to have used drugs at least one time, and 12 (2.7%) regularly use injected drugs. One participant was elderly, single, heterosexual, with a history of unprotected sex and multiple sexual partners. This study detected a low prevalence of HCV infection and recorded the presence of HCV genotype 2 for the first time among PLWH in the Brazilian Amazon. |
| doi_str_mv | 10.3390/jcm11247284 |
| format | Article |
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This study aimed to identify the prevalence and genotypes of HCV among people living with HIV (PLWH), both neglected chronic diseases in the Amazon region. From March 2016 to June 2017, 433 PWLH were attended to at two sexually transmitted infection referral centers in the city of Belém, in the Brazilian state of Pará in the Amazon region. All individuals were submitted to testing via the rapid immunochromatographic assay (RIA) for the qualitative detection of anti-HCV antibodies. Samples with anti-HCV antibodies were evaluated by reverse transcriptase polymerase chain reaction (RT-PCR), and samples with HCV RNA were subjected to nucleotide sequencing and phylogenetic analysis. Three (0.7%) PLWH had anti-HCV antibodies, and only one (0.2%) had HCV RNA (genotype 2); of these, 31 (7.1%) self-declared to have used drugs at least one time, and 12 (2.7%) regularly use injected drugs. One participant was elderly, single, heterosexual, with a history of unprotected sex and multiple sexual partners. This study detected a low prevalence of HCV infection and recorded the presence of HCV genotype 2 for the first time among PLWH in the Brazilian Amazon.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11247284</identifier><identifier>PMID: 36555906</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Antibodies ; Clinical medicine ; Communication ; Drugs ; Genomes ; Genotype & phenotype ; Hepatitis C ; HIV ; Human immunodeficiency virus ; Infections ; Informed consent ; Liver cancer ; Phylogenetics ; Polymerase chain reaction ; Public health ; RNA polymerase ; Sexually transmitted diseases ; Software ; STD</subject><ispartof>Journal of clinical medicine, 2022-12, Vol.11 (24), p.7284</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c367t-fe211e87142ae5ffd43be1956ef6c1d3d3858630600e602162f1484f166f22a93</cites><orcidid>0000-0002-4571-4715 ; 0000-0002-4888-3530 ; 0000-0002-5894-304X ; 0000-0002-9335-6932 ; 0000-0003-0312-0553</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785546/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785546/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36555906$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lobo, Marcio Nahum</creatorcontrib><creatorcontrib>Irias, Susan Denice Flores</creatorcontrib><creatorcontrib>Neto, Pedro Leão Fontes</creatorcontrib><creatorcontrib>Avelino, Maria Eduarda Sousa</creatorcontrib><creatorcontrib>da Silva Torres, Maria Karoliny</creatorcontrib><creatorcontrib>de Carvalho Souza, Marlinda</creatorcontrib><creatorcontrib>Fonseca, Ricardo Roberto Souza</creatorcontrib><creatorcontrib>Freitas, Pedro Eduardo Bonfim</creatorcontrib><creatorcontrib>Nunes, Heloisa Marceliano</creatorcontrib><creatorcontrib>de Araújo Júnior, José Raul Rocha</creatorcontrib><creatorcontrib>de Brito, Dickson Ciro Nascimento</creatorcontrib><creatorcontrib>Oliveira-Filho, Aldemir Branco</creatorcontrib><creatorcontrib>Machado, Luiz Fernando Almeida</creatorcontrib><title>HCV-HIV Chronic Coinfection Prevalence in Amazon Region</title><title>Journal of clinical medicine</title><addtitle>J Clin Med</addtitle><description>Hepatitis C virus (HCV) infection is an important public health problem, especially in areas with a low human development index such as the Amazon region. This study aimed to identify the prevalence and genotypes of HCV among people living with HIV (PLWH), both neglected chronic diseases in the Amazon region. From March 2016 to June 2017, 433 PWLH were attended to at two sexually transmitted infection referral centers in the city of Belém, in the Brazilian state of Pará in the Amazon region. All individuals were submitted to testing via the rapid immunochromatographic assay (RIA) for the qualitative detection of anti-HCV antibodies. Samples with anti-HCV antibodies were evaluated by reverse transcriptase polymerase chain reaction (RT-PCR), and samples with HCV RNA were subjected to nucleotide sequencing and phylogenetic analysis. Three (0.7%) PLWH had anti-HCV antibodies, and only one (0.2%) had HCV RNA (genotype 2); of these, 31 (7.1%) self-declared to have used drugs at least one time, and 12 (2.7%) regularly use injected drugs. One participant was elderly, single, heterosexual, with a history of unprotected sex and multiple sexual partners. This study detected a low prevalence of HCV infection and recorded the presence of HCV genotype 2 for the first time among PLWH in the Brazilian Amazon.</description><subject>Antibodies</subject><subject>Clinical medicine</subject><subject>Communication</subject><subject>Drugs</subject><subject>Genomes</subject><subject>Genotype & phenotype</subject><subject>Hepatitis C</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Infections</subject><subject>Informed consent</subject><subject>Liver cancer</subject><subject>Phylogenetics</subject><subject>Polymerase chain reaction</subject><subject>Public health</subject><subject>RNA polymerase</subject><subject>Sexually transmitted diseases</subject><subject>Software</subject><subject>STD</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkc1Lw0AQxRdRrNSevEvAiyDR_ch-5CJIUFsoKKK9LtvtbJuS7NZNW9C_3pTWUp3LDDM_Hm94CF0QfMtYju_mtiaEZpKq7AidUSxliplixwdzB_WaZo7bUiqjRJ6iDhOc8xyLMyT7xSjtD0ZJMYvBlzYpQukd2GUZfPIaYW0q8BaS0icPtflul28wbW_n6MSZqoHernfRx9Pje9FPhy_Pg-JhmFom5DJ1QAkBJUlGDXDnJhkbA8m5ACcsmbAJU1wJhgXGIDAlgjqSqcwRIRylJmdddL_VXazGNUws-GU0lV7EsjbxSwdT6r8XX870NKx1LhXnmWgFrncCMXyuoFnqumwsVJXxEFaNppIrnOe5Ui169Q-dh1X07XsbSkhKFGctdbOlbAxNE8HtzRCsN5nog0xa-vLQ_579TYD9ACeghK8</recordid><startdate>20221208</startdate><enddate>20221208</enddate><creator>Lobo, Marcio Nahum</creator><creator>Irias, Susan Denice Flores</creator><creator>Neto, Pedro Leão Fontes</creator><creator>Avelino, Maria Eduarda Sousa</creator><creator>da Silva Torres, Maria Karoliny</creator><creator>de Carvalho Souza, Marlinda</creator><creator>Fonseca, Ricardo Roberto Souza</creator><creator>Freitas, Pedro Eduardo Bonfim</creator><creator>Nunes, Heloisa Marceliano</creator><creator>de Araújo Júnior, José Raul Rocha</creator><creator>de Brito, Dickson Ciro Nascimento</creator><creator>Oliveira-Filho, Aldemir Branco</creator><creator>Machado, Luiz Fernando Almeida</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4571-4715</orcidid><orcidid>https://orcid.org/0000-0002-4888-3530</orcidid><orcidid>https://orcid.org/0000-0002-5894-304X</orcidid><orcidid>https://orcid.org/0000-0002-9335-6932</orcidid><orcidid>https://orcid.org/0000-0003-0312-0553</orcidid></search><sort><creationdate>20221208</creationdate><title>HCV-HIV Chronic Coinfection Prevalence in Amazon Region</title><author>Lobo, Marcio Nahum ; 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This study aimed to identify the prevalence and genotypes of HCV among people living with HIV (PLWH), both neglected chronic diseases in the Amazon region. From March 2016 to June 2017, 433 PWLH were attended to at two sexually transmitted infection referral centers in the city of Belém, in the Brazilian state of Pará in the Amazon region. All individuals were submitted to testing via the rapid immunochromatographic assay (RIA) for the qualitative detection of anti-HCV antibodies. Samples with anti-HCV antibodies were evaluated by reverse transcriptase polymerase chain reaction (RT-PCR), and samples with HCV RNA were subjected to nucleotide sequencing and phylogenetic analysis. Three (0.7%) PLWH had anti-HCV antibodies, and only one (0.2%) had HCV RNA (genotype 2); of these, 31 (7.1%) self-declared to have used drugs at least one time, and 12 (2.7%) regularly use injected drugs. 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| source | MDPI - Multidisciplinary Digital Publishing Institute; PMC (PubMed Central); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central Open Access |
| subjects | Antibodies Clinical medicine Communication Drugs Genomes Genotype & phenotype Hepatitis C HIV Human immunodeficiency virus Infections Informed consent Liver cancer Phylogenetics Polymerase chain reaction Public health RNA polymerase Sexually transmitted diseases Software STD |
| title | HCV-HIV Chronic Coinfection Prevalence in Amazon Region |
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